WBGene00006792 | SMap | S_parent | Sequence | T06H11 |
| Identity | Version | 3 |
| | Name | CGC_name | unc-58 | Person_evidence | WBPerson261 |
| | | Sequence_name | T06H11.1 |
| | | Molecular_name (21) |
| | | Other_name | twk-18 | CGC_data_submission |
| | | | CELE_T06H11.1 | Accession_evidence | NDB | BX284606 |
| | | Public_name | unc-58 |
| | DB_info | Database | AceView | gene | XK722 |
| | | | WormQTL | gene | WBGene00006792 |
| | | | WormFlux | gene | WBGene00006792 |
| | | | NDB | locus_tag | CELE_T06H11.1 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00006792|UniProtKB=Q22271 |
| | | | | family | PTHR11003 |
| | | | NCBI | gene | 181224 |
| | | | RefSeq | protein | NM_171758.5 |
| | | | | | NM_001373460.3 |
| | | | | | NM_001373459.2 |
| | | | | | NM_001373458.4 |
| | | | | | NM_001373457.2 |
| | | | | | NM_001373456.2 |
| | | | | | NM_171759.6 |
| | | | SwissProt | UniProtAcc | Q22271 |
| | | | TrEMBL | UniProtAcc | A0A4V0IKI8 |
| | | | | | A0A4V0IL39 |
| | | | | | A0A4V0IKM3 |
| | | | | | A0A4V0INP7 |
| | | | | | A0A4V0INX3 |
| | | | UniProt_GCRP | UniProtAcc | Q22271 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | | | 2 | 20 May 2019 15:21:47 | WBPerson4025 | Event | Acquires_merge | WBGene00011553 |
| | | | 3 | 20 May 2019 15:21:47 | WBPerson4025 | Event | Acquires_merge | WBGene00011552 |
| | | Acquires_merge | WBGene00011553 |
| | | | WBGene00011552 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | unc |
| | Reference_allele | WBVar00143382 |
| | Allele (568) |
| | Legacy_information | e665dm : `shaker' : animals short rigidly paralysed with constant shaking of body; e665/+ phenotype similar but weaker animals slightly longer and less rigid. ES3 ME0. NA (dominant) 5 (e415 n495 (similar phenotype) e778 (weaker phenotype)). Dominant alleles revert intragenically e.g. e665e2112 : recessive weak Unc (probable null phenotype). |
| | | See also e415, e665, e757, e778, e1320, e2112, n272, n276, n278, n284, n286, n288, n495, n1273 |
| | | [Reiner D]] Mac-h (Hyper-ACtivate Muscle) |
| | | [C.elegansII] e665dm : `shaker', animals short, rigidly paralysed with constant shaking of body; e665/+ phenotype similar but weaker, animals slightly longer and less rigid. Muscle hyperactivated, sticky pumping, short.ES3 ME0. OA4 (dominant): e415, n495 (similar), e778 (weaker phenotype), etc. Dominant alleles revert intragenically e.g. e665e2112 : recessive weak Unc (probable null phenotype). [Brenner 1974; Park and Horvitz 1986; JT] |
| | Strain | WBStrain00026762 |
| | | WBStrain00026763 |
| | | WBStrain00026792 |
| | | WBStrain00027002 |
| | | WBStrain00004431 |
| | | WBStrain00004508 |
| | | WBStrain00004193 |
| | | WBStrain00006242 |
| | | WBStrain00055081 |
| | | WBStrain00054759 |
| | RNASeq_FPKM (74) |
| | GO_annotation (18) |
| | Ortholog (35) |
| | Paralog (47) |
| | Structured_description | Concise_description | unc-58 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains; unc-58 was originally defined by gain-of-function (gf) mutations that result in paralysis and a shortened (dumpy) body morphology due to hypercontraction of body wall muscle; unc-58 gf mutations also result in constitutive egg-laying; as loss of UNC-58 function via reversion or RNA-mediated interference (RNAi) results in either no abnormalities or only a weakly uncoordinated phenotype, UNC-58 likely functions redudantly with other TWK channels to regulate locomotion and egg-laying; UNC-58 is expressed in motor neurons and interneurons. | Paper_evidence | WBPaper00002305 |
| | | | | | WBPaper00002665 |
| | | | | | WBPaper00004644 |
| | | | | | WBPaper00005654 |
| | | | | | WBPaper00017138 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Automated_description | Enables outward rectifier potassium channel activity. Involved in several processes, including muscle contraction; parturition; and regulation of muscle contraction. Predicted to be located in membrane. Expressed in interneuron and motor neurons. Is an ortholog of human KCNK17 (potassium two pore domain channel subfamily K member 17) and KCNK5 (potassium two pore domain channel subfamily K member 5). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | T06H11.1a |
| | | T06H11.1b |
| | | T06H11.1c |
| | | T06H11.1d |
| | | T06H11.1e |
| | | T06H11.1f |
| | | T06H11.1g |
| | Corresponding_CDS_history | T06H11.1:wp83 |
| | Corresponding_transcript | T06H11.1a.1 |
| | | T06H11.1b.1 |
| | | T06H11.1c.1 |
| | | T06H11.1d.1 |
| | | T06H11.1e.1 |
| | | T06H11.1f.1 |
| | | T06H11.1g.1 |
| | Other_sequence (29) |
| | Associated_feature (17) |
| Experimental_info | RNAi_result (16) |
| | Expr_pattern | Expr2448 |
| | | Expr1020117 |
| | | Expr1021035 |
| | | Expr1028695 |
| | | Expr1032862 |
| | | Expr1156295 |
| | | Expr1156296 |
| | | Expr1156298 |
| | | Expr2017890 |
| | | Expr2036026 |
| | Drives_construct | WBCnstr00010838 |
| | | WBCnstr00030566 |
| | | WBCnstr00030567 |
| | | WBCnstr00034146 |
| | Construct_product | WBCnstr00010838 |
| | | WBCnstr00030566 |
| | | WBCnstr00030567 |
| | | WBCnstr00034146 |
| | Microarray_results (51) |
| | Expression_cluster | WBPaper00030922:glycosylated_protein |
| | | WBPaper00031040:TGF-beta_adult_upregulated |
| | | WBPaper00032976:dosage_compensated_genes |
| | | WBPaper00037055:DAF-16_binding_DNA |
| | | WBPaper00037946:EGL-5_interacting |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_larva_enriched |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038061:aldicarb_upregulated |
| | | WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_downregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:P.lumniescens_24hr_downregulated_TilingArray |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray |
| | | WBPaper00042477:rsr-2(RNAi)_upregulated_TilingArray |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045390:tunicamycin_downregulated |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Spermatogenic |
| | | WBPaper00045774:clk-1_downregulated |
| | | WBPaper00046012:tdp-1(ok803)_upregulated |
| | | WBPaper00046509:htz-1(ok3099)_downregulated |
| | | WBPaper00047131:daf-2(e1370)_upregulated_N2-background |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00050370:dpy-21(e428)_L3_downregulated |
| | | WBPaper00050370:dpy-21(e428)_L3_upregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00051404:alg-2(ok304)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(ot269)_upregulated |
| | | WBPaper00053388:dauer_regulated_Cluster1 |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00053888:drh-3(rrr2)_downregulated |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055103:thoc-5(wy822)_upregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:Psora-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Metformin_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated |
| | | WBPaper00055354:Rapamycin_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055354:Rifampicin-Psora_downregulated |
| | | WBPaper00055354:Rifampicin_downregulated |
| | | WBPaper00055482:Tunicamycin_downregulated |
| | | WBPaper00055565:AVK_enriched |
| | | WBPaper00055626:pry-1(mu38)_downregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056284:ints-1(RNAi)_downregulated |
| | | WBPaper00056284:ints-11(RNAi)_downregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056617:adr-1_upregulated_embryo_transcript |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057041:spc-1(cas971)_downregulated |
| | | WBPaper00057041:unc-70(cas983)_downregulated |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058969:RIS_enriched |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059527:lsm-1_upregulated_L1 |
| | | WBPaper00059566:wdr-23(mac32)_upregulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061007:S.aquatilis_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:DA_DB |
| | | WBPaper00061340:IL1 |
| | | WBPaper00061340:OLL |
| | | WBPaper00061340:SMB |
| | | WBPaper00061527:176662_at-Y53F4B.16 |
| | | WBPaper00061527:sre-33-ZK1025.1_8337 |
| | | WBPaper00061527:unc-13_19769-unc-13_278 |
| | | WBPaper00061572:oleic-acid-specific_mating_downregulated |
| | | WBPaper00061651:ALM_enriched |
| | | WBPaper00061651:DA9_enriched |
| | | WBPaper00061651:PHC_enriched |
| | | WBPaper00061651:PLM_enriched |
| | | WBPaper00061651:PVD_enriched |
| | | WBPaper00061651:RME_DV_enriched |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062590:Aging_downregulated_neuron |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs |
| | | WBPaper00064509:static-magnetic-field_upregulated |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064721:fasn-1(g14)_downregulated_starved |
| | | WBPaper00064769:him-17(me24)_upregulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065835:Day5_vs_Day1_downregulated |
| | | WBPaper00065835:Day11_vs_Day1_downregulated |
| | | WBPaper00065841:20_0 |
| | | WBPaper00065841:22_0 |
| | | WBPaper00065841:23_0 |
| | | WBPaper00065841:44_0 |
| | | WBPaper00065841:55_0 |
| | | WBPaper00065841:56_0 |
| | | WBPaper00065841:70_0 |
| | | WBPaper00065841:122_0 |
| | | WBPaper00065841:134_0 |
| | | WBPaper00065841:136_0 |
| | | WBPaper00065841:140_0 |
| | | WBPaper00065975:P-body_vs_oocyte_depleted |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14 |
| | | cgc4489_group_16 |
| | | cgc4489_group_23 |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_upregulated |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Enriched_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00027111:rrf-1(pk1417)_upregulated |
| | | WBPaper00030839:Embryo_A_Class |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00036123:Cadmium_regulated |
| | | WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated |
| | | WBPaper00040858:eQTL_age_regulated_aging |
| | | WBPaper00040858:eQTL_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_juvenile |
| | | WBPaper00040858:eQTL_regulated_old |
| | | WBPaper00040858:eQTL_regulated_reproductive |
| | | WBPaper00040876:mir-35_downregulated |
| | | WBPaper00040963:Q100_down |
| | | WBPaper00040963:Q200_down |
| | | WBPaper00040985:AIN-2_asynchronous_intestine |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h |
| | | WBPaper00046853:AOBr_M.aeruginosa-batch-culture_upregulated |
| | | [cgc6390]:Cluster_A |
| | Interaction | WBInteraction000028423 |
| | | WBInteraction000136892 |
| | | WBInteraction000165840 |
| | | WBInteraction000200024 |
| | | WBInteraction000243038 |
| | | WBInteraction000331659 |
| | | WBInteraction000418934 |
| | | WBInteraction000430959 |
| | | WBInteraction000456312 |
| | | WBInteraction000585544 |
| Map_info | Map | X | Position | 1.75032 | Error | 0.007954 |
| | Well_ordered |
| | Positive | Inside_rearr | stDp2 |
| | | | nDf19 |
| | | Positive_clone | T06H11 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point (15) |
| | | Multi_point | 442 |
| | | | 551 |
| | | | 651 |
| | | | 791 |
| | | | 792 |
| | | | 1343 |
| | | | 2260 |
| | | | 2454 |
| | | | 4314 |
| | | | 4494 |
| | | Pos_neg_data | 272 |
| | | | 497 |
| | | | 942 |
| | | | 656 |
| | | | 661 |
| Reference | WBPaper00000031 |
| | WBPaper00000565 |
| | WBPaper00000608 |
| | WBPaper00000914 |
| | WBPaper00001709 |
| | WBPaper00002305 |
| | WBPaper00002485 |
| | WBPaper00004376 |
| | WBPaper00005927 |
| | WBPaper00006103 |
| | WBPaper00013889 |
| | WBPaper00014961 |
| | WBPaper00015071 |
| | WBPaper00016043 |
| | WBPaper00016713 |
| | WBPaper00017024 |
| | WBPaper00017174 |
| | WBPaper00017414 |
| | WBPaper00017685 |
| | WBPaper00021740 |
| | WBPaper00022012 |
| | WBPaper00022642 |
| | WBPaper00023739 |
| | WBPaper00023964 |
| | WBPaper00026748 |
| | WBPaper00027237 |
| | WBPaper00027249 |
| | WBPaper00028462 |
| | WBPaper00029020 |
| | WBPaper00038491 |
| | WBPaper00038946 |
| | WBPaper00040284 |
| | WBPaper00041300 |
| | WBPaper00048092 |
| | WBPaper00052540 |
| | WBPaper00052822 |
| | WBPaper00055090 |
| | WBPaper00056919 |
| | WBPaper00059990 |
| | WBPaper00062373 |
| | WBPaper00064001 |
| | WBPaper00064887 |
| | WBPaper00065105 |
| Remark | The other-name twk-18 is different from the CGC-approved main name twk-18 (C24A3.6) | CGC_data_submission |
| Method | Gene |