WBGene00006747 | SMap | S_parent | Sequence | CHROMOSOME_X |
| Identity | Version | 3 |
| | Name | CGC_name | unc-7 | Person_evidence | WBPerson261 |
| | | Sequence_name | R07D5.1 |
| | | Molecular_name (31) |
| | | Other_name | unc-12 |
| | | | unc-124 | Person_evidence | WBPerson621 |
| | | | | | WBPerson579 |
| | | | CELE_R07D5.1 | Accession_evidence | NDB | BX284606 |
| | | Public_name | unc-7 |
| | DB_info | Database | AceView | gene | XP740 |
| | | | WormQTL | gene | WBGene00006747 |
| | | | WormFlux | gene | WBGene00006747 |
| | | | NDB | locus_tag | CELE_R07D5.1 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00006747|UniProtKB=Q03412 |
| | | | | family | PTHR11893 |
| | | | NCBI | gene | 181608 |
| | | | RefSeq | protein | NM_001350352.4 |
| | | | | | NM_001350353.4 |
| | | | | | NM_001270327.3 |
| | | | | | NM_001350355.3 |
| | | | | | NM_001350356.3 |
| | | | | | NM_001350358.3 |
| | | | | | NM_001350354.3 |
| | | | | | NM_001392896.1 |
| | | | | | NM_001270326.3 |
| | | | | | NM_001350357.3 |
| | | | SwissProt | UniProtAcc | Q03412 |
| | | | TrEMBL | UniProtAcc | A0A1T5HUM5 |
| | | | | | C8JQR8 |
| | | | | | A0A1T5HUM9 |
| | | | | | A0A1T5HUM1 |
| | | | | | A0A1T5HUM6 |
| | | | | | A0A1T5HUM7 |
| | | | | | A0A1T5HUM3 |
| | | | | | C8JQR7 |
| | | | | | A0A1T5HUN4 |
| | | | UniProt_GCRP | UniProtAcc | Q03412 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | | | 2 | 23 Aug 2005 13:14:37 | WBPerson2970 | Event | Acquires_merge | WBGene00006847 |
| | | | | | | Name_change | Other_name | unc-124 |
| | | | 3 | 03 Mar 2017 00:18:26 | WBPerson1983 | Event | Acquires_merge | WBGene00007526 |
| | | Acquires_merge | WBGene00006847 |
| | | | WBGene00007526 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | unc |
| | Reference_allele | WBVar00142903 |
| | Allele (496) |
| | Legacy_information | e5 : moves backward better than forward kinker in forward movement active healthy slightly thin. ES3 ME0. NA5 (e42 e65 (pka unc-12) etc.). |
| | | See unc-7. |
| | | See also e65 |
| | | [C.elegansII] e5 : moves backward better than forward, kinker in forward movement, active, healthy, slightly thin. Suppresses anaesthetic hypersensitivity of unc-79 and unc-80 mutants. e5/Df similar, null phenotype.ES3 ME0. OA>20: e42, e65 (pka unc-12, weaker), bx5::Tc1, st197, mn384 (weaker allele), etc.; also revertants bx5mn369 etc. Cloned: main transcript 2.9 kb, encodes predicted 522 aa membrane protein related to EAT-5, Drosophila passover (26%identity), etc; possible gap junction component. [Starich et al. 1993; Morgan and Sedensky 1994; EH; SP] |
| | | [Hecht RM ] cold sensitive, uncoordinated kinker at 11C, WT at 23C, phenotype reversible within hours of temperature shift, throughout development. Dominant interaction with some unc-7 alleles. NA1. |
| | | [C.elegansII] hs10cs : uncoordinated at 11C, kinker;WT 23C; phenotype reversible within hoursof temp shift, throughout development. Dominant interaction with some unc-7vt-4alleles. NA1,[HH] |
| | Strain (12) |
| | RNASeq_FPKM (74) |
| | GO_annotation (41) |
| | Ortholog (33) |
| | Paralog | WBGene00000488 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | WormBase-Compara |
| | | WBGene00001136 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00002123 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00002124 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00002125 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00002127 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00002128 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00002129 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00002130 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00002131 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00002132 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00002133 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00002134 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00002135 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00002136 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00002137 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00002138 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00002139 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00002140 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00002141 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00002142 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00002143 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00002144 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00006749 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | unc-7 encodes an innexin required for gap junction formation in invertebrates; UNC-7 is also required for normal locomotion, egg-laying, inhibition of feeding by tapping, avermectin sensitivity, and ivermectin sensitivity, as well as for the antagonism of UNC-79 and UNC-80 activity by volatile anesthetics; unc-7 is genetically required, and transcribed in, neurons rather than muscle cells, from larval stages L1 through L4; homologs of UNC-7 include Drosophila OGRE and SHAKING-B, as well as 24 C. elegans paralogs (including EAT-5, UNC-9, and INX-1 through INX-20); UNC-7 genetically interacts with UNC-124, and unc-7 mutants are phenotypically similar to unc-9 and unc-124 mutants; UNC-7 genetically interacts with AVR-14 and GLC-1 in the response to ivermectin. | Paper_evidence (11) |
| | | | | Curator_confirmed | WBPerson567 |
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Automated_description | Enables gap junction channel activity. Involved in several processes, including regulation of multicellular organismal process; reproductive behavior; and response to anesthetic. Located in gap junction and neuron projection membrane. Expressed in several structures, including OL socket cell; intestine; muscle cell; neurons; and pharyngeal gland cell. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | R07D5.1a |
| | | R07D5.1b |
| | | R07D5.1c |
| | | R07D5.1d |
| | | R07D5.1e |
| | | R07D5.1f |
| | | R07D5.1g |
| | | R07D5.1h |
| | | R07D5.1i |
| | | R07D5.1j |
| | Corresponding_transcript (11) |
| | Other_sequence (45) |
| | Associated_feature (33) |
| Experimental_info | RNAi_result (14) |
| | Expr_pattern (20) |
| | Drives_construct (12) |
| | Construct_product | WBCnstr00013477 |
| | | WBCnstr00014601 |
| | | WBCnstr00020987 |
| | | WBCnstr00020988 |
| | | WBCnstr00021037 |
| | | WBCnstr00022281 |
| | | WBCnstr00022773 |
| | | WBCnstr00033676 |
| | | WBCnstr00034176 |
| | | WBCnstr00042489 |
| | Antibody | WBAntibody00000520 |
| | | WBAntibody00001906 |
| | | WBAntibody00001921 |
| | Microarray_results (40) |
| | Expression_cluster | WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:Harposporium_24hr_downregulated_RNAseq |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray |
| | | WBPaper00040560:hpl-2_embryo_upregulated |
| | | WBPaper00042194:nhr-114(RNAi)_downregulated |
| | | WBPaper00044037:eat-2_upregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044760:somatic_specific |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049001:EVN_enriched |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049626:UNC-75_target |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo |
| | | WBPaper00050163:let-418(RNAi)_upregulated_24-cell-embryo |
| | | WBPaper00050370:dpy-21(e428)_L3_upregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050990:arcade_intestinal-valve_enriched |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00051404:alg-1(gk214)_upregulated |
| | | WBPaper00051404:alg-2(ok304)_upregulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(icb38)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053388:dauer_regulated_Cluster4 |
| | | WBPaper00053888:drh-3(rrr2)_downregulated |
| | | WBPaper00054493:hpl-2(tm1489)_upregulated |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055013:hmg-3(bar24)_downregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_upregulated |
| | | WBPaper00055354:Rifampicin-Psora_upregulated |
| | | WBPaper00055386:daf-2(e1370)_downregulated |
| | | WBPaper00055565:AVK_enriched |
| | | WBPaper00055626:pry-1(mu38)_downregulated |
| | | WBPaper00055827:pfd-6(gk493446)_downregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058725:sftb-1(cer6)_downregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated |
| | | WBPaper00059421:daf-3(mgDf90)_downregulated |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059566:wdr-23(mac32)_upregulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00060100:SiNP_upregulated_mRNA |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00061007:S.aquatilis_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:AIZ |
| | | WBPaper00061340:AVB |
| | | WBPaper00061340:AVE |
| | | WBPaper00061340:DVA |
| | | WBPaper00061340:FLP |
| | | WBPaper00061340:I5 |
| | | WBPaper00061340:Neuroblast_AIZ_FLP |
| | | WBPaper00061340:RIB |
| | | WBPaper00061340:RMD |
| | | WBPaper00061340:SIB |
| | | WBPaper00061340:SMD |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061424:Diet_MYb120_upregulated |
| | | WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061527:176662_at-Y53F4B.16 |
| | | WBPaper00061527:sre-33-ZK1025.1_8337 |
| | | WBPaper00061651:AIZ_enriched |
| | | WBPaper00061651:I4_enriched |
| | | WBPaper00061902:camt-1(ok515)_regulated_RMG |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062446:nhr-8(hd117)_upregulated |
| | | WBPaper00062585:hlh-26(ok1453)_upregulated_E.faecium |
| | | WBPaper00064005:starvation_upregulated_aptf-1(gk794)_protein |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064156:lbp-3(overexpress)_upregulated |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064661:lpd-3(ok2138)_upregulated |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064769:him-17(me24)_upregulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065749:Heat-Shock_downregulated_N2 |
| | | WBPaper00065841:19_0 |
| | | WBPaper00065841:52_0 |
| | | WBPaper00065841:61_0 |
| | | WBPaper00065841:70_1 |
| | | WBPaper00065841:86_0 |
| | | WBPaper00065841:87_0 |
| | | WBPaper00065841:131_0 |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | cgc4489_group_19 |
| | | cgc4489_group_21 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00027111:eri-1(mg366)_upregulated |
| | | WBPaper00027111:rde-3(r459)_upregulated |
| | | WBPaper00027111:rrf-1(pk1417)_upregulated |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00036123:Fluoranthene_regulated |
| | | WBPaper00040210:Chlorpyrifos_16C_regulated |
| | | WBPaper00042548:miRISC_enriched |
| | | WBPaper00045294:50uM_DBAA_downregulated |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_upregulated |
| | Interaction (84) |
| Map_info | Map | X | Position | 22.0336 | Error | 0.049576 |
| | Well_ordered |
| | Positive | Inside_rearr | mnDf19 |
| | | | mnDp26 |
| | | Positive_clone | C26D6 |
| | | | R07D5 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point (17) |
| | | Multi_point (26) |
| | | Pos_neg_data (23) |
| | Landmark_gene |
| Reference (115) |
| Remark | Cloned, positive rescue by ZK1098 [Byrd D, Jin Y]. krb 14/11/01 |
| Method | Gene |