WormBase Tree Display for Gene: WBGene00022642

WBGene00022642 SMap: S_parent: Sequence: ZK6
  Identity: Version: 2
    Name: CGC_name: lipl-5 Person_evidence: WBPerson3759
            WBPerson7490
            WBPerson545
      Sequence_name: ZK6.7
      Molecular_name: ZK6.7a
        ZK6.7a.1
        CE18444
        ZK6.7c
        CE50798
        ZK6.7d
        CE50743
        ZK6.7b
        ZK6.7c.1
        ZK6.7d.1
      Other_name: CELE_ZK6.7 Accession_evidence: NDB BX284605
      Public_name: lipl-5
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:06 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 19 Jul 2010 13:43:13 WBPerson2970 Name_change: CGC_name: lipl-5
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: lipl
    Allele: WBVar00094550 Inferred_automatically: From strain object: RB2573
      WBVar02149123 Inferred_automatically: From strain object: VC3788
      WBVar02135553
      WBVar01499528
      WBVar01499167
      WBVar01457478
      WBVar01457479
      WBVar01457480
      WBVar01457481
      WBVar01457482
      WBVar00447638
      WBVar00447639
      WBVar00447640
      WBVar00447641
      WBVar00447642
      WBVar00447643
      WBVar01499740
      WBVar01499775
      WBVar00979112
      WBVar00979113
      WBVar01735037
      WBVar00979114
      WBVar00979115
      WBVar00979116
      WBVar00979117
      WBVar00979118
      WBVar00979119
      WBVar00979120
      WBVar00979121
      WBVar00979122
      WBVar02121626
      WBVar00979123
      WBVar00979124
      WBVar00979125
      WBVar00979126
      WBVar02031486
      WBVar00979127
      WBVar00979128
      WBVar00979129
      WBVar00979130
      WBVar00979131
      WBVar00979132
      WBVar01773375
      WBVar01773376
      WBVar01773377
      WBVar01773378
      WBVar02151414
    Strain: WBStrain00033248
      WBStrain00037811
    RNASeq_FPKM (74)
    GO_annotation (14)
    Ortholog (66)
    Paralog: WBGene00008510 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00009773 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00010062 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00013050 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00019376 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00020016 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00021963 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
    Structured_description: Concise_description: lipl-5 encodes a lipase; lipl-5 is expressed in the intestine and its expression is negatively regulated in well-fed animals by MXL-3; lipl-5 expression is induced upon bacterial infection. Paper_evidence: WBPaper00005382
            WBPaper00042295
          Curator_confirmed: WBPerson1843
          Date_last_updated: 19 Jun 2013 00:00:00
      Automated_description: Predicted to enable hydrolase activity, acting on ester bonds. Involved in defense response to Gram-negative bacterium; lipid homeostasis; and triglyceride catabolic process. Located in lysosome. Expressed in coelomocyte and intestine. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; and cholesterol ester storage disease. Is an ortholog of several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPJ (lipase family member J). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0080217 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6617)
      DOID:14502 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6617)
      DOID:14497 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6617)
      DOID:0060717 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:23452)
  Molecular_info: Corresponding_CDS: ZK6.7a
      ZK6.7c
      ZK6.7d
    Corresponding_CDS_history: ZK6.7b:wp248
    Corresponding_transcript: ZK6.7b
      ZK6.7a.1
      ZK6.7c.1
      ZK6.7d.1
    Other_sequence (34)
    Associated_feature: WBsf999148
      WBsf1019064
      WBsf231319
      WBsf231320
      WBsf231321
  Experimental_info: RNAi_result (12)
    Expr_pattern: Expr1967
      Expr14545
      Expr14546
      Expr1010508
      Expr1162960
      Expr2013207
      Expr2031439
    Drives_construct: WBCnstr00041084
    Construct_product: WBCnstr00041084
    Microarray_results (23)
    Expression_cluster: WBPaper00029087:4-methylsterol_upregulated
      WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00032528:L3_enriched
      WBPaper00033065:clk-1(qm30)_upregulated
      WBPaper00033065:isp-1-1(qm150)_upregulated
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:intestine_CoreEnriched
      WBPaper00037950:intestine_embryo_enriched
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:intestine_larva_enriched
      WBPaper00037950:pharyngeal-muscle_embryo_enriched
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038168:lin-15B(n744)_downregulated
      WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00040209:B.thuringiensis_downregulated_MY15
      WBPaper00040209:B.thuringiensis_downregulated_MY18
      WBPaper00040990:PA14_downregulated
      WBPaper00041954:ethanol_upregulated
      WBPaper00042561:smgl-1(RNAi)_downregulated
      WBPaper00044030:nhr-8(hd117)_downregulated
      WBPaper00044316:CH3HgCl_7.5uM_downregulated
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045257:bar-1(ga80)_downregulated
      WBPaper00045316:prg-1_upregulated_L1
      WBPaper00045401:N.parisii_40h_downregulated
      WBPaper00045401:N.parisii_64h_downregulated
      WBPaper00045417:128Q-huntingtin_upreglated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00045934:wrn-1(gk99)_upregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046499:AMPK_regulated
      WBPaper00046795:starvation_downregulated
      WBPaper00047131:daf-2(e1370)_downregulated_hel-1(gk148684)-background
      WBPaper00048926:miaserin_upregulated_adult-day3
      WBPaper00048971:daf-16(mgDf50)_upregulated_L1
      WBPaper00048988:neuron_expressed
      WBPaper00049334:CE_intestine_enriched
      WBPaper00049368:daf-2(e1370)_downregulated
      WBPaper00049484:elt-2(RNAi)_downregulated_L1
      WBPaper00049498:npr-1(ur89)_regulated_3
      WBPaper00049545:cco-1(RNAi)_downregulated
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050080:rbr-2(tm3141)_upregulated
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_24-cell-embryo
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_100-cell-embryo
      WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo
      WBPaper00050163:chd-3(eh4)_downregulated_100-cell-embryo
      WBPaper00050193:dpy-27(RNAi)_downregulated_L1
      WBPaper00050332:daf-16(RNAi)_downregulated
      WBPaper00050412:cco-1(RNAi)_downregulated_N2
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00051039:intestine_enriched
      WBPaper00051265:F4_hrde-1(tm1200)_downregulated
      WBPaper00051305:vit-2(ac3)_downregulated
      WBPaper00051388:Glucose-diet_downregulated
      WBPaper00051404:alg-2(ok304)_downregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053154:human-amyloid-beta_tau_regulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053388:dauer_regulated_Cluster5
      WBPaper00053599:female_vs_male_downregulated
      WBPaper00053606:elt-2(ca15)_vs_elt-2(ca15);elt-7(tm840)_doenregulated
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_downregulated
      WBPaper00053606:N2_vs_elt-2(ca15)_downregulated
      WBPaper00053713:Pheromone-induced_postdauer_vs_control_downregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053792:Ochrobactrum_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00053814:15C_downregulated_PY79
      WBPaper00053814:25C_upregulated_OP50
      WBPaper00054410:set-26(tm2467)_downregulated
      WBPaper00054758:alg-1(gk204)_downregulated
      WBPaper00055103:thoc-5(wy822)_downregulated
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00055827:daf-2(e1370)_downregulated
      WBPaper00055969:electromagnetic-field_upregulated
      WBPaper00056039:hda-6(ok3203)_downregulated
      WBPaper00056039:ptl-1(ok621)_upregulated
      WBPaper00056073:NHR-86_interacting_promoter
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056139:gut-microbiota_downregulated
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056275:P.aeruginosa_downregulated
      WBPaper00056275:P.aeruginosa_downregulated_atf-7(qd22qd130)_dependent
      WBPaper00056284:ints-2(RNAi)_downregulated
      WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected
      WBPaper00056446:hsb-1(cg116)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay1
      WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay4
      WBPaper00056586:kri-1(ok1251)_downregulated
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00056826:hmc_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057006:DietaryRestriction_downregulated
      WBPaper00057265:metaformin_upregulated_OP50
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058958:100mGy-irradiation-72h_upregulated
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059203:CAR-1_interacting
      WBPaper00059253:stearic-acid_upregulated
      WBPaper00059253:sucrose_stearic-acid_upregulated
      WBPaper00059253:sucrose_upregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059609:malt-1_ilc-17.1_nfki-1_downregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059824:rnp-6(dh1127)_regulated_OP50
      WBPaper00060084:cco-1(RNAi)_downregulated_N2
      WBPaper00060100:SiNP_downregulated_mRNA
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_N2
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060871:M.humicola-extract_4h_regulated
      WBPaper00060871:M.humicola-infection_48h_regulated
      WBPaper00060911:prx-5(RNAi)_upregulated_mRNA
      WBPaper00060951:metr-1(os521)_downregulated
      WBPaper00061274:hypergravity_15xg_downregulated
      WBPaper00061340:g1P
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061390:N2_ascarosides_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061479:ubc-9(ne4833)_upregulated
      WBPaper00061527:R10H10.3-T21H3.1
      WBPaper00061530:nhr-49(e2144)_downregulated
      WBPaper00061590:CGP37157_upregulated
      WBPaper00061613:human-amyloid-beta_downregulated
      WBPaper00061651:Intestine_enriched
      WBPaper00061753:csr-1(tor159)_upregulated_25C
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062305:P.brevicompactum_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062446:nhr-8(hd117)_downregulated
      WBPaper00062446:nhr-8(ok186)_downregulated
      WBPaper00062456:doxycycline_upregulated_CB4856_protein
      WBPaper00062534:fat-P-80_downregulated
      WBPaper00062534:fat-P-80_downregulated_ech-6(RNAi)
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064005:starvation_upregulated_aptf-1(gk794)_mRNA
      WBPaper00064005:starvation_upregulated_N2_mRNA
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
      WBPaper00064539:nhr-114(gk849)_upregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064728:cpl-1(W32AY35A)_upregulated
      WBPaper00064769:him-17(me24)_downregulated
      WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
      WBPaper00064952:Day10_vs_Day5_downregulated_25C
      WBPaper00065086:JU1400_N.ausubeli_regulated
      WBPaper00065086:JU1400_N.ferruginous_regulated
      WBPaper00065086:N2_N.ausubeli_regulated
      WBPaper00065086:N2_N.ferruginous_regulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065149:lin-52(n771)_downregulated
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065392:Lb.delbrueckii_downregulated
      WBPaper00065392:Lb.gasseri_downregulated
      WBPaper00065392:Lb.plantarum_downregulated
      WBPaper00065392:Lb.reuteri_downregulated
      WBPaper00065392:P.pentosaceus_downregulated
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065835:mtH2S-AP39-D0-treatment_upregulated_Day11
      WBPaper00065841:3_0
      WBPaper00065841:3_1
      WBPaper00065841:3_2
      WBPaper00065841:3_5
      WBPaper00065945:epidermis-rpoa-2(-)_upregulated_protein
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00065995:M.humicola-extract_upregulated_N2
      WBPaper00066085:hda-3(ok1991)_upregulated
      WBPaper00066085:sin-3(syb2172)_upregulated
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      WBPaper00066204:CdCl2_downregulated_mRNA
      WBPaper00066232:ash-2(RNAi)_downregulated_WT
      WBPaper00066232:hsf-1(RNAi)_downregulated_ash-2
      cgc4489_group_1
      WBPaper00005124:progesterone_10-7M_regulated
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Enriched_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00028789:PA14_vs_gacA_downregulated_8hr
      WBPaper00028789:PA14_vs_OP50_downregulated_8hr
      WBPaper00030839:Embryo_A_Class
      WBPaper00030985:Photorhabdus_luminescens_upregulated
      WBPaper00031060:2-deoxy-D-glucose_downregulated
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00031662:spaceflight_downregulated
      WBPaper00031850:mdt-15(RNAi)_downregulated
      WBPaper00032062:age_regulated_genes
      WBPaper00033101:spr-5_regulated
      WBPaper00035424:ASER_up
      WBPaper00035479:daf-16(RNAi)_downregulated
      WBPaper00035479:glucose_downregulated
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035873:osm-7_regulated
      WBPaper00035873:osm-8_regulated
      WBPaper00035873:osm-11_regulated
      WBPaper00035873:osmotically_regulated
      WBPaper00036123:Atrazine_regulated
      WBPaper00036123:Cadmium_regulated
      WBPaper00036123:Fluoranthene_regulated
      WBPaper00036130:mir-243_down_regulated
      WBPaper00036383:ash-2_Day8_regulated
      WBPaper00038231:Cry5B_1.5-fold_downregulated
      WBPaper00038462:aging_downregulated
      WBPaper00040184:hcf-1down_sir-2.1up_daf-2nc
      WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
      WBPaper00040823:alg-1(gk214)_upregulated
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_regulated_reproductive
      WBPaper00041002:HF_3d_0.2mM_Up
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041906:I-4317_vs_OP50_10d
      WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00042234:xpa-1_upregulated
      WBPaper00044091:Bpseudomallei_regulated_qPCR-confirmed
      WBPaper00044091:Bpseudomallei_repressed_8h
      WBPaper00044091:Bpseudomallei_repressed_12h
      WBPaper00044535:male_downregulated
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045263:isp-1(qm150)_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00045263:ProLongevity-mtROS_upregulated
      WBPaper00047070:N2_UV_upregulated
      WBPaper00048637:lin-35(n745)_starvation_downregulated
      WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO
      WBPaper00048989:N2_rapamycin_downregulated
      WBPaper00053550:daf-19(m86)_upregulated_L1
    Interaction (38)
    WBProcess: WBbiopr:00000039
  Map_info: Map: V Position: -20
    Positive: Positive_clone: ZK6 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (12)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene