WormBase Tree Display for Gene: WBGene00019376
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| WBGene00019376 | SMap | S_parent | Sequence | K04A8 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | lipl-4 | Paper_evidence | WBPaper00032310 | |||||
| Person_evidence | WBPerson3759 | ||||||||
| WBPerson7490 | |||||||||
| WBPerson545 | |||||||||
| Sequence_name | K04A8.5 | ||||||||
| Molecular_name | K04A8.5a | ||||||||
| K04A8.5a.1 | |||||||||
| CE11708 | |||||||||
| K04A8.5b | |||||||||
| CE50646 | |||||||||
| K04A8.5b.1 | |||||||||
| Other_name | CELE_K04A8.5 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | lipl-4 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:01 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 19 Jul 2010 13:43:13 | WBPerson2970 | Name_change | CGC_name | lipl-4 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lipl | ||||||||
| Allele (35) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (17) | |||||||||
| Ortholog (41) | |||||||||
| Paralog | WBGene00008510 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00009773 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00010062 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00013050 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00022642 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00020016 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00021963 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | lipl-4 encodes a triglyceride lipase; by homology, LIPL-4 is predicted to function in lipid hydrolysis; genetic studies indicate that lipl-4 functions as part of an endocrine signaling pathway that coordinates reproductive status, fat metabolism, and longevity; in response to reduced insulin signaling or germline removal (glp-1 mutant animals), lipl-4 expression is induced in the intestine, in a DAF-16-dependent manner; overexpression of lipl-4 can extend lifespan, in a manner dependent upon autophagy genes, such as bec-1, vps-34, and lgg-1. | Paper_evidence | WBPaper00032310 | |||||
| WBPaper00040180 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 25 Jan 2012 00:00:00 | ||||||||
| Automated_description | Enables triglyceride lipase activity. Involved in cellular lipid metabolic process; determination of adult lifespan; and positive regulation of macroautophagy. Located in lysosome. Expressed in intestine and seam cell. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; and cholesterol ester storage disease. Is an ortholog of several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPJ (lipase family member J). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0080217 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6617) | ||||
| DOID:14502 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6617) | ||||||
| DOID:14497 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6617) | ||||||
| DOID:0060717 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:23452) | ||||||
| Molecular_info | Corresponding_CDS | K04A8.5a | |||||||
| K04A8.5b | |||||||||
| Corresponding_transcript | K04A8.5a.1 | ||||||||
| K04A8.5b.1 | |||||||||
| Other_sequence (15) | |||||||||
| Associated_feature | WBsf718324 | ||||||||
| WBsf231890 | |||||||||
| Experimental_info | RNAi_result (16) | ||||||||
| Expr_pattern | Expr8612 | ||||||||
| Expr9651 | |||||||||
| Expr1014707 | |||||||||
| Expr1153580 | |||||||||
| Expr2013206 | |||||||||
| Expr2031438 | |||||||||
| Drives_construct | WBCnstr00014203 | ||||||||
| WBCnstr00016041 | |||||||||
| WBCnstr00017679 | |||||||||
| WBCnstr00025878 | |||||||||
| Construct_product | WBCnstr00014203 | ||||||||
| WBCnstr00016041 | |||||||||
| WBCnstr00018401 | |||||||||
| WBCnstr00020107 | |||||||||
| WBCnstr00020237 | |||||||||
| WBCnstr00025878 | |||||||||
| Regulate_expr_cluster | WBPaper00064156:lipl-4(overexpress)_downregulated | ||||||||
| WBPaper00064156:lipl-4(overexpress)_upregulated | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (154) | |||||||||
| Interaction (112) | |||||||||
| WBProcess | WBbiopr:00000001 | ||||||||
| WBbiopr:00000121 | |||||||||
| Map_info | Map | V | Position | 0.065955 | Error | 0.00487 | |||
| Positive | Positive_clone | K04A8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (28) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
