WormBase Tree Display for Gene: WBGene00019327

WBGene00019327 SMap: S_parent: Sequence: K02F3
  Identity: Version: 2
    Name: CGC_name: zip-2 Person_evidence: WBPerson1997
            WBPerson460
      Sequence_name: K02F3.4
      Molecular_name: K02F3.4
        K02F3.4.1
        CE23848
        K02F3.4.2
        K02F3.4.3
      Other_name: CELE_K02F3.4 Accession_evidence: NDB BX284603
      Public_name: zip-2
    DB_info: Database: AceView gene 3B453
        WormQTL gene WBGene00019327
        WormFlux gene WBGene00019327
        NDB locus_tag CELE_K02F3.4
        Panther gene CAEEL|WormBase=WBGene00019327|UniProtKB=Q21148
          family PTHR23334
        NCBI gene 175240
        RefSeq protein NM_001384015.2
        SwissProt UniProtAcc Q21148
        TREEFAM TREEFAM_ID TF317134
        UniProt_GCRP UniProtAcc Q21148
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:01 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 18 Jul 2005 13:34:00 WBPerson2970 Name_change: CGC_name: zip-2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: zip
    Allele (51)
    Strain: WBStrain00037649
    RNASeq_FPKM (74)
    GO_annotation (25)
    Ortholog (23)
    Paralog: WBGene00016754 Caenorhabditis elegans From_analysis: Panther
      WBGene00016997 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00017755 Caenorhabditis elegans From_analysis: Panther
      WBGene00021552 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: zip-2 encodes a bZIP transcription factor; ZIP-2 activity is required for regulating one branch of the immune response pathway that responds to infection by virulent strains of the bacterial pathogen Pseudomonas aeruginosa; specifically, ZIP-2 is required for inducing expression of a subset of infection response genes, including irg-1 and irg-2, and for full resistance to P. aeruginosa infection. Paper_evidence: WBPaper00027309
            WBPaper00035891
          Curator_confirmed: WBPerson1843
          Date_last_updated: 08 Feb 2010 00:00:00
      Automated_description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in defense response to bacterium and positive regulation of macromolecule biosynthetic process. Predicted to be located in nucleus. Expressed in pharynx. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Modifies_disease: DOID:14330
  Modifies_disease_in_annotation: WBDOannot00000499
  Molecular_info: Corresponding_CDS: K02F3.4
    Corresponding_transcript: K02F3.4.1
      K02F3.4.2
      K02F3.4.3
    Other_sequence (25)
    Associated_feature (16)
    Gene_product_binds (249)
    Transcription_factor: WBTranscriptionFactor000223
  Experimental_info: RNAi_result (25)
    Expr_pattern: Expr7776
      Expr10045
      Expr1020648
      Expr1038353
      Expr1153467
      Expr2018156
      Expr2036293
    Drives_construct: WBCnstr00012921
      WBCnstr00015019
      WBCnstr00015163
      WBCnstr00019915
      WBCnstr00022575
      WBCnstr00025914
    Construct_product: WBCnstr00016820
      WBCnstr00018893
      WBCnstr00018894
      WBCnstr00019915
      WBCnstr00022575
      WBCnstr00025914
    Regulate_expr_cluster: WBPaper00035891:PA_induced_zip-2_dependent
      WBPaper00035891:zip-2(RNAi)_downregulated
      WBPaper00035891:zip-2(RNAi)_upregulated
      WBPaper00053605:zip-2(RNAi)_downregulated
      WBPaper00053605:zip-2(RNAi)_upregulated
    Microarray_results (21)
    Expression_cluster: WBPaper00028867:HLH-1_induced_TF
      WBPaper00028867:PAL-1_induced_TF
      WBPaper00032528:L3_enriched
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00033444:BacteriaDiet_regulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037682:sma-2_upregulated
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038118:aak-2(gt33)_upregulated
      WBPaper00038118:stress_upregulated_N2
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00040990:PA14_upregulated
      WBPaper00042561:smg-2(RNAi)_upregulated
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044736:flat_dev_expression
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_upregulated
      WBPaper00045974:NSM_enriched_DSN-treated_RNAseq
      WBPaper00045974:NSM_enriched_totalRNA_RNAseq
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h
      WBPaper00048988:neuron_expressed
      WBPaper00049001:EVN_enriched
      WBPaper00049498:npr-1(ur89)_regulated_1
      WBPaper00049626:UNC-75_target
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00050053:muscle_enriched_Day4
      WBPaper00050053:muscle_enriched_Day12
      WBPaper00050182:lmn-1(L535P)_downregulated
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:intestine_enriched
      WBPaper00051558:fog-2(q71)_regulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053388:dauer_regulated_Cluster6
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056034:pals-25(jy9)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056443:DietaryRestriction_upregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056826:SGP_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057162:meg-3_meg-4_upregulated_sRNA
      WBPaper00058691:cfp-1(tm6369)_downregulated
      WBPaper00058691:set-2(bn129)_downregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059191:hsp-16.2p-LIN-29_downregulated
      WBPaper00059194:KLF-1_interacting
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059421:daf-1(m40)_upregulated
      WBPaper00059471:EGL-43_interacting
      WBPaper00059567:olrn-1(ums9)_regulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059763:neuron_expressed
      WBPaper00059839:S.maltophilia_regulated
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_N2
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061007:HB101_upregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061007:X.citri_upregulated
      WBPaper00061040:FW1256_downregulated
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061274:microgravity_downregulated
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061527:kin-29_2839-unc-9_3883
      WBPaper00061651:ASG_enriched
      WBPaper00061651:DB_enriched
      WBPaper00061651:DVB_enriched
      WBPaper00061651:IL2_DV_enriched
      WBPaper00061651:IL2_LR_enriched
      WBPaper00061651:MI_enriched
      WBPaper00061651:PDE_enriched
      WBPaper00061651:RIB_enriched
      WBPaper00061651:SIA_enriched
      WBPaper00061651:SIB_enriched
      WBPaper00061651:VB01_enriched
      WBPaper00061651:VB02_enriched
      WBPaper00061651:VB_enriched
      WBPaper00061651:VD_DD_enriched
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00062056:lin-35(n745)_upregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062184:PA14_upregulated
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062456:doxycycline_upregulated_CB4856_transcript
      WBPaper00062456:doxycycline_upregulated_N2_transcript
      WBPaper00064055:trl-1(cas1077)_downregulated_non-starved
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064156:lbp-3(overexpress)_upregulated
      WBPaper00064315:mes-3(bn199)_upregulated_PGCs
      WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
      WBPaper00064716:paraquat_downregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065835:Day11_vs_Day1_upregulated
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066085:hda-3(ok1991)_upregulated
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00066232:ash-2(RNAi)_downregulated_WT
      cgc4386_cluster_6_2
      WBPaper00006465:II_ethanol_late_induction
      WBPaper00025032:cluster_2
      WBPaper00025099:MA_specific
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00028789:pmk-1_upregulated
      WBPaper00029437:dcr-1_upregulated
      WBPaper00031060:2-deoxy-D-glucose_upregulated
      WBPaper00031832:slr-2_regulated
      WBPaper00032165:differentially_expressed_with_age_medoid_2
      WBPaper00035227:heat_shock_regulated
      WBPaper00035429:UVC_upregulated
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035891:PA_induced_zip-2_dependent
      WBPaper00035891:zip-2(RNAi)_downregulated
      WBPaper00036130:mir-243_up_regulated
      WBPaper00036286:Pattern_D
      WBPaper00037901:GLD-1_mRNA_targets
      WBPaper00038172:tax-6null_up_regulated
      WBPaper00038231:Cry5B_1.5-fold_upregulated
      WBPaper00038427:lin-54_embryo_changed
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040823:alg-1(gk214)_upregulated
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040858:eQTL_regulated_juvenile
      WBPaper00040985:AIN-2_asynchronous_intestine
      WBPaper00041002:HF_3d_0.2mM_Up
      WBPaper00041002:HQ_3d_2.0mM_Up
      WBPaper00041174:environmental
      WBPaper00041174:genotype_environment_interaction
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_and_environmental
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_EtBr-exposed_51h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:control_vs_UVC-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00042258:DA1877_upregulated_GravidAdult
      WBPaper00044091:Bpseudomallei_induced_2h
      WBPaper00044091:Bpseudomallei_induced_4h
      WBPaper00044091:Bpseudomallei_induced_8h
      WBPaper00044091:Bpseudomallei_induced_12h
      WBPaper00045015:acs-3(ft5)_upregulated
      WBPaper00045015:nhr-25(RNAi)_upregulated
      WBPaper00045673:colistin_upregulated
      WBPaper00045865:biofilm_upregulated_A
      WBPaper00047070:xpa-1_UV_upregulated
      WBPaper00048624:hlh-25(ok1710)_upregulated
      WBPaper00048637:lin-35(n745)_starvation_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00050515:pmk-1(km25)_downregulated
      WBPaper00050520:lagr-1(gk327);hyl-1(ok976)_upregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      [cgc5767]:cluster_2
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(66_min)
      [cgc5767]:expression_class_SE
      [cgc5767]:expression_class_SE_pi(66_min)
      [cgc6390]:Cluster_A
    Interaction (49)
    WBProcess: WBbiopr:00000008
      WBbiopr:00000039
  Map_info: Map: III Position: -25.7689
    Positive: Positive_clone: K02F3 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (32)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
    [200811 gw3] Modified Map position as it was a reverse physical that could not be fixed by automated methods. (-25.7711)
  Method: Gene