WormBase Tree Display for Gene: WBGene00011232

WBGene00011232 SMap: S_parent: Sequence: R11A5
  Identity: Version: 2
    Name: CGC_name: pck-2 Person_evidence: WBPerson2192
      Sequence_name: R11A5.4
      Molecular_name (13)
      Other_name: CELE_R11A5.4 Accession_evidence: NDB BX284601
      Public_name: pck-2
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:52 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 17 Feb 2012 16:57:01 WBPerson2970 Name_change: CGC_name: pck-2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: pck
    Allele (66)
    Possibly_affected_by: WBVar02153165
    Strain: WBStrain00002263
      WBStrain00032650
      WBStrain00049322
    RNASeq_FPKM (74)
    GO_annotation (22)
    Ortholog (45)
    Paralog: WBGene00021043 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00019151 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: pck-2 is one of three C. elegans genes that encode proteins with similarity to phosphoenolpyruvate carboxykinase (PEPCK); by similarity, the products of pck-2 are predicted to function in gluconeogenesis. Curator_confirmed: WBPerson1843
          Date_last_updated: 02 Aug 2011 00:00:00
      Automated_description: Predicted to enable manganese ion binding activity and phosphoenolpyruvate carboxykinase (GTP) activity. Predicted to be involved in several processes, including carbohydrate biosynthetic process; cellular response to oxygen-containing compound; and propionate catabolic process. Predicted to be located in cytosol and mitochondrion. Expressed in several structures, including body wall musculature; hypodermis; muscle cell; pharynx; and in male. Human ortholog(s) of this gene implicated in Alzheimer's disease and type 2 diabetes mellitus. Is an ortholog of human PCK1 (phosphoenolpyruvate carboxykinase 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:10652 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:8724)
      DOID:9352 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:8724)
  Molecular_info: Corresponding_CDS: R11A5.4a
      R11A5.4b
      R11A5.4c
      R11A5.4d
    Corresponding_CDS_history: R11A5.4b:wp274
    Corresponding_transcript: R11A5.4a.1
      R11A5.4a.2
      R11A5.4b.1
      R11A5.4c.1
      R11A5.4d.1
    Other_sequence (359)
    Associated_feature (19)
  Experimental_info: RNAi_result: WBRNAi00116976 Inferred_automatically: RNAi_primary
      WBRNAi00051760 Inferred_automatically: RNAi_primary
      WBRNAi00077181 Inferred_automatically: RNAi_primary
      WBRNAi00090555 Inferred_automatically: RNAi_primary
      WBRNAi00034849 Inferred_automatically: RNAi_primary
      WBRNAi00001222 Inferred_automatically: RNAi_primary
      WBRNAi00051759 Inferred_automatically: RNAi_primary
      WBRNAi00004079 Inferred_automatically: RNAi_primary
    Expr_pattern (16)
    Drives_construct: WBCnstr00002285
      WBCnstr00004292
      WBCnstr00004926
      WBCnstr00011844
      WBCnstr00030823
      WBCnstr00042040
      WBCnstr00042041
    Construct_product: WBCnstr00030823
      WBCnstr00042040
    Microarray_results (41)
    Expression_cluster: WBPaper00006195:azacoprostane_downregulated
      WBPaper00026640:Development_Group_VI
      WBPaper00027022:tax-6(jh107)_upregulated
      WBPaper00029359_1142
      WBPaper00029359_1187
      WBPaper00029359_1217
      WBPaper00029359_1280
      WBPaper00029359_1444
      WBPaper00029359_1504
      WBPaper00029359_1524
      WBPaper00029359_1604
      WBPaper00030894:daf-2(e1370ts)_upregulated
      WBPaper00031040:Cluster_3
      WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00033065:isp-1-1(qm150)_upregulated
      WBPaper00035073:mitochondria_protein
      WBPaper00035926:A.hydrophila_regulated
      WBPaper00035963:S.aureus_4h_upregulated
      WBPaper00035963:S.aureus_8h_downregulated
      WBPaper00035963:S.aureus_8h_upregulated
      WBPaper00035963:S.aureus_24h_downregulated
      WBPaper00035963:S.aureus_24h_upregulated
      WBPaper00036662:oxidative_modification
      WBPaper00037047:insoluble_protein
      WBPaper00037055:DAF-16_binding_DNA
      WBPaper00037946:LIN-39_interacting
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:intestine_embryo_enriched
      WBPaper00037950:intestine_embryo_SelectivelyEnriched
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038118:aak-2(gt33)_upregulated
      WBPaper00038289:oocyte_protein
      WBPaper00038357:atx-3_regulated_heat-shock
      WBPaper00040134:nhr-49(RNAi)_regulated_protein
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00040446:insoluble_protein
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044746:aging_downregulated_Day5
      WBPaper00044746:aging_downregulated_HeatShock
      WBPaper00045417:128Q-huntingtin_upreglated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Oogenic
      WBPaper00045774:clk-1_upregulated
      WBPaper00045934:wrn-1(gk99)_upregulated
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046509:lin-35(n745)_downregulated
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00048923:Aging_regulated
      WBPaper00048952:glucose_induced
      WBPaper00048971:daf-16(mgDf50)_downregulated_L1
      WBPaper00048988:neuron_expressed
      WBPaper00050015:ifg-1(RNAi)_upregulated
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050636:aging_regulated_insoluble_protein
      WBPaper00050698:DEP-1_interacting
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:intestine_enriched
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051538:micro-gavity_downregulated_protein
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053321:embryo-to-L1_upregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
      WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053388:dauer_regulated_Cluster3
      WBPaper00053599:mitosis_vs_meiosis_downregulated
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053810:clk-1(qm30)_upregulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:isp-1(qm150)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055103:thoc-5(wy822)_downregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Psora_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055969:electromagnetic-field_upregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056139:gut-microbiota_downregulated
      WBPaper00056161:hermaphrodite_enriched_siRNA
      WBPaper00056275:P.aeruginosa_downregulated
      WBPaper00056275:P.aeruginosa_downregulated_atf-7(qd22qd130)_dependent
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00056868:P.aeruginosa_downregulated_smallRNA
      WBPaper00056900:PID-3_interacting
      WBPaper00056900:TOFU-6_interacting
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057265:metaformin_upregulated_OP50
      WBPaper00057288:Cold_downregulated_protein
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058691:cfp-1(tm6369)_downregulated
      WBPaper00058691:set-2(bn129)_downregulated
      WBPaper00058691:sin-3(tm1276)_upregulated
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00058725:sftb-1(cer39)_downregulated
      WBPaper00058948:PA14_upregulated
      WBPaper00058969:RIS_depleted
      WBPaper00059174:MEG-3_interacting
      WBPaper00059253:sucrose_stearic-acid_upregulated
      WBPaper00059253:sucrose_upregulated
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059440:LAG-1_interacting_germline
      WBPaper00059471:EGL-43_interacting
      WBPaper00059605:MUT-16_interacting
      WBPaper00059816:crh-1(n3315)_downrgulated
      WBPaper00059932:cnd-1(ju29)_downregulated
      WBPaper00059932:cnd-1(ju29)_upregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060871:M.humicola-extract_24h_regulated
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061340:BWM_anterior
      WBPaper00061340:BWM_far_posterior
      WBPaper00061340:Intestinal_and_rectal_muscle
      WBPaper00061377:MYRF-1_interacting
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061527:vem-1-ugt-58
      WBPaper00061530:nhr-49(e2144)_downregulated
      WBPaper00061651:AVL_enriched
      WBPaper00061651:CAN_enriched
      WBPaper00061651:Coelomocyte_enriched
      WBPaper00061651:DA9_enriched
      WBPaper00061651:PDA_enriched
      WBPaper00061651:RIP_enriched
      WBPaper00061651:RMF_enriched
      WBPaper00061651:VA12_enriched
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062293:isp-1(qm150)_upregulated
      WBPaper00062325:etr-1(lq61)_upregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064122:vulva_transcriptome
      WBPaper00064163:ZNFX-1_interacting_embryo
      WBPaper00064201:SNA-1_interacting
      WBPaper00064201:SNA-3_interacting
      WBPaper00064257:UNG-1_interacting
      WBPaper00064315:mes-3(bn199)_upregulated_PGCs
      WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
      WBPaper00064532:pals-25(icb98)_upregulated
      WBPaper00064632:daf-2(e1370)_upregulated_intestine
      WBPaper00064637:cox-5B(RNAi)_upregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064871:hypoxia_downregulated_F3
      WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
      WBPaper00064933:E.coli-binding_secret_protein
      WBPaper00065086:JU1400_N.ferruginous_regulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065373:sek-1(km4)_upregulated_Ref
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066085:hda-3(ok1991)_upregulated
      WBPaper00066085:sin-3(syb2172)_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      cgc4386_cluster_2_3
      cgc4489_group_10
      WBPaper00005124:estrogen_10-5M_regulated
      WBPaper00025032:PAL-1_target_genes
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00027758:Group_I
      WBPaper00030985:Enterococcus_faecalis_downregulated
      WBPaper00031003:0hr_muscle_enriched
      WBPaper00031003:total_muscle_enriched
      WBPaper00031850:mdt-15(RNAi)_downregulated
      WBPaper00032062:age_regulated_genes
      WBPaper00032948:StarveUp3
      WBPaper00036286:Pattern_I
      WBPaper00037695:WC_5-day
      WBPaper00039835:ifg-1_upregulated
      WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up
      WBPaper00040426:CYD-1_CDK-4_downregulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040858:eQTL_regulated_reproductive
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041960:daf-16_fasting_upregulated
      WBPaper00041960:jun-1_fasting_upregulated
      WBPaper00041960:N2_fasting_upregulated
      WBPaper00041960:N2_fasting_upregulated_9hto12h
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00042178:hlh-29(tm284)_upregulated
      WBPaper00044091:Bpseudomallei_repressed_12h
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00048989:N2_allantoin_downregulated
      WBPaper00053236:daf-16(mgDF50)_regulated_Starved
      WBPaper00053236:Starvation_regulated_N2
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
      [cgc5976]:class_1
    Interaction (47)
  Map_info: Map: I Position: 2.38327
    Positive: Positive_clone: R11A5 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (22)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
    [200811 gw3] Modified Map position as it was a reverse physical that could not be fixed by automated methods. (2.36373)
  Method: Gene