WormBase Tree Display for Gene: WBGene00010742

WBGene00010742 SMap: S_parent: Sequence: K10D6
  Identity: Version: 2
    Name: CGC_name: clc-6 Person_evidence: WBPerson260
      Sequence_name: K10D6.2
      Molecular_name (16)
      Other_name: CELE_K10D6.2 Accession_evidence: NDB BX284605
      Public_name: clc-6
    DB_info: Database: AceView gene 5L674
        WormQTL gene WBGene00010742
        WormFlux gene WBGene00010742
        NDB locus_tag CELE_K10D6.2
        Panther gene CAEEL|WormBase=WBGene00010742|UniProtKB=O45669
          family PTHR10671
        NCBI gene 179548
        RefSeq protein NM_073442.4
            NM_001383401.1
            NM_001373109.3
            NM_001380762.2
        TREEFAM TREEFAM_ID TF316179
        TrEMBL UniProtAcc E9P878
            O45669
            O45670
            Q9NAP4
        UniProt_GCRP UniProtAcc O45669
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:51 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 19 Apr 2021 01:27:01 WBPerson1983 Name_change: CGC_name: clc-6
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: clc
    Allele (33)
    Strain: WBStrain00037210
    RNASeq_FPKM (74)
    GO_annotation: 00008450
      00008451
      00118089
    Ortholog (29)
    Paralog: WBGene00000522 Caenorhabditis elegans From_analysis: Panther
      WBGene00000523 Caenorhabditis elegans From_analysis: TreeFam
            Panther
      WBGene00000526 Caenorhabditis elegans From_analysis: TreeFam
            Panther
      WBGene00021415 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00011014 Caenorhabditis elegans From_analysis: TreeFam
      WBGene00016706 Caenorhabditis elegans From_analysis: Panther
      WBGene00016067 Caenorhabditis elegans From_analysis: TreeFam
            WormBase-Compara
    Structured_description: Concise_description: K10D6.2 encodes three isoforms of a claudin homolog that may be required for normal cohesion of apical junctions in epithelia; K10D6.2A-C are worm-specific, with obvious homologs only in C. elegans; K10D6.2A-C are required for embryonic viability in mass RNAi assays; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water. Paper_evidence: WBPaper00004651
            WBPaper00004961
            WBPaper00005946
            WBPaper00005975
            WBPaper00012856
            WBPaper00018356
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to be located in plasma membrane. Expressed in ciliated neurons and hypodermis. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: K10D6.2a
      K10D6.2b
      K10D6.2c
      K10D6.2d
    Corresponding_CDS_history: K10D6.2a:wp227
      K10D6.2c:wp114
      K10D6.2d:wp227
    Corresponding_transcript: K10D6.2a.1
      K10D6.2b.1
      K10D6.2b.2
      K10D6.2c.1
      K10D6.2c.2
      K10D6.2c.3
      K10D6.2c.4
      K10D6.2d.1
    Other_sequence (36)
    Associated_feature (14)
  Experimental_info: RNAi_result: WBRNAi00050542 Inferred_automatically: RNAi_primary
      WBRNAi00034262 Inferred_automatically: RNAi_primary
      WBRNAi00001132 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr3179
      Expr1025973
      Expr1034703
      Expr1154247
      Expr2005037
      Expr2023256
    Drives_construct: WBCnstr00011199
      WBCnstr00031180
    Construct_product: WBCnstr00011199
      WBCnstr00031180
    Microarray_results (34)
    Expression_cluster: WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00035197:fer-1_downregulated
      WBPaper00037682:sma-2_sma-4_upregulated
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:dopaminergic-neurons_larva_enriched
      WBPaper00037950:dopaminergic-neurons_larva_SelectivelyEnriched
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:hypodermis_larva_enriched
      WBPaper00037950:hypodermis_larva_SelectivelyEnriched
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00040209:B.thuringiensis_upregulated_MY18
      WBPaper00044037:eat-2_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00045417:128Q-huntingtin_downreglated
      WBPaper00046012:tdp-1(ok803)_upregulated
      WBPaper00046121:ecdoderm_unique
      WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_downregulated
      WBPaper00046337:polysomal_N2_vs_daf-2_downregulated
      WBPaper00046887:WNT-target
      WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00048988:neuron_expressed
      WBPaper00049217:TCER-1_downregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049635:dop-1(vs100)_upregulated
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(OverExpression)_vs_N2_regulated_adult_20C
      WBPaper00050743:elli-1(sam-3)_downregulated
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051245:cytoplasm_specific
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_specific
      WBPaper00051265:F4_hrde-1(tm1200)_downregulated
      WBPaper00051352:Long-Term-Association-Memory_upregulated
      WBPaper00051404:alg-1(gk214)_upregulated
      WBPaper00051404:alg-2(ok304)_upregulated
      WBPaper00051558:aging_regulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:stavudine_72h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053388:dauer_regulated_Cluster3
      WBPaper00053615:SMO-1_target
      WBPaper00053771:up_at_24h-NaCl
      WBPaper00053771:up_at_dpy-7(e88)
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055386:daf-2(e1370)_upregulated
      WBPaper00055648:male-tail_expressed
      WBPaper00055827:daf-2(e1370)_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056284:ints-1(RNAi)_downregulated
      WBPaper00056330:glycine_downregulated
      WBPaper00056443:DietaryRestriction_upregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056826:SGP_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057068:numr-1(RNAi)_downregulated
      WBPaper00057154:HeatShock_downregulated_miRNA-target
      WBPaper00057154:HeatShock_upregulated_mRNA
      WBPaper00057347:nhr-14(tm1473)_downreglated
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058691:set-2(bn129)_upregulated
      WBPaper00058711:paraquat_downregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated
      WBPaper00059421:daf-3(mgDf90)_downregulated
      WBPaper00059471:EGL-43_interacting
      WBPaper00059609:malt-1_ilc-17.1_nfki-1_downregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060273:isp-1(qm150)_upregulated
      WBPaper00060445:ikb-1(nr2027)_downregulated_L4
      WBPaper00060445:nfki-1(cer1)_downregulated_L4
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060703:nas-38(ok3407)_upregulated
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061007:HB101_upregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061081:E.faecalis_upregulated_skpo-1(ok1640)
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:ADEsh
      WBPaper00061340:Anterior_arcade_cell
      WBPaper00061340:AWB
      WBPaper00061340:CEP
      WBPaper00061340:CEPso
      WBPaper00061340:Excretory_duct_and_pore
      WBPaper00061340:G2_and_W_blasts
      WBPaper00061340:hyp1V_and_ant_arc_V
      WBPaper00061340:hyp3
      WBPaper00061340:IL1
      WBPaper00061340:IL1_parent
      WBPaper00061340:IL2
      WBPaper00061340:ILso
      WBPaper00061340:Neuroblast_ADE_ADA
      WBPaper00061340:OLL
      WBPaper00061340:OLQ
      WBPaper00061340:OLQ_parent
      WBPaper00061340:Tail_hypodermis
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061479:mep-1(ne4629)_upregulated
      WBPaper00061527:R07G3.8_9125-ric-4_17408
      WBPaper00061651:IL2_DV_enriched
      WBPaper00061651:PHso_enriched
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00061995:mter-4(syb3662syb3403)_downregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062184:PA14_downregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062440:crh-1(n3315)_downregulated
      WBPaper00062440:crh-1(syb385)_downregulated
      WBPaper00062446:nhr-8(hd117)_upregulated
      WBPaper00062456:doxycycline_upregulated_N2_protein
      WBPaper00062715:blmp-1(s71)_upregulated
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064158:xpo-1(RNAi)_upregulated
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064661:lpd-3(ok2138)_upregulated
      WBPaper00064721:fasn-1(g14)_downregulated_starved
      WBPaper00064871:hypoxia_downregulated_F2
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065623:77
      WBPaper00065749:endu-2(tm4977)_upregulated
      WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
      WBPaper00065749:Heat-Shock_downregulated_N2
      WBPaper00065835:Day11_vs_Day1_upregulated
      WBPaper00065841:27_0
      WBPaper00065841:34_0
      WBPaper00065841:64_0
      WBPaper00065841:146_0
      WBPaper00065926:pgph-2(overepxreesion)_upregulated_glucose
      WBPaper00065945:epidermis-rpoa-2(-)_upregulated_protein
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      cgc4386_cluster_6_6
      WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00029437:dcr-1_upregulated
      WBPaper00030985:Erwinia_carotovora_upregulated
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:hlh_1_enriched
      WBPaper00031003:total_muscle_depleted
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00034757:up_by_oxidative_stress
      WBPaper00035084:L4_enriched_AIN-2_IP
      WBPaper00035227:heat_shock_regulated
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035873:osm-8_regulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036130:mir-243_up_regulated
      WBPaper00038060:SUMO-1_downregulated
      WBPaper00038172:tax-6null_up_regulated
      WBPaper00038304:octr-1_regulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.5
      WBPaper00040823:alg-1(gk214)_upregulated
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00041002:HF_3d_0.2mM_Up
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041002:HF_11d_0.2mM_Up
      WBPaper00041002:HQ_3d_2.0mM_Up
      WBPaper00041174:environmental
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_and_environmental
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:control_vs_UVC-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00045263:0.1mM-paraquat_downregulated
      WBPaper00045263:nuo-6(qm200)_downregulated
      WBPaper00045673:colistin_upregulated
      WBPaper00047070:xpa-1_UV_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00048989:N2_rapamycin_upregulated
      WBPaper00050538:Fasting_upregulated
      WBPaper00056330:mrps-5(RNAi)_upregulated
      WBPaper00057098:SiO2-nanoparticles_upregulated
    Interaction: WBInteraction000551579
      WBInteraction000581956
  Map_info: Map: V Position: 2.97044
    Positive: Positive_clone: K10D6 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene