WormBase Tree Display for Gene: WBGene00000522
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| WBGene00000522 | SMap | S_parent | Sequence | C09F12 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | clc-1 | |||||||
| Sequence_name | C09F12.1 | ||||||||
| Molecular_name | C09F12.1 | ||||||||
| C09F12.1.1 | |||||||||
| CE08040 | |||||||||
| C09F12.1.2 | |||||||||
| Other_name | CELE_C09F12.1 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | clc-1 | ||||||||
| DB_info | Database | AceView | gene | XL667 | |||||
| WormQTL | gene | WBGene00000522 | |||||||
| WormFlux | gene | WBGene00000522 | |||||||
| NDB | locus_tag | CELE_C09F12.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00000522|UniProtKB=Q93198 | |||||||
| family | PTHR10671 | ||||||||
| NCBI | gene | 181293 | |||||||
| RefSeq | protein | NM_077446.6 | |||||||
| TREEFAM | TREEFAM_ID | TF316995 | |||||||
| TrEMBL | UniProtAcc | Q93198 | |||||||
| UniProt_GCRP | UniProtAcc | Q93198 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | clc | ||||||||
| Allele (32) | |||||||||
| Strain | WBStrain00032606 | ||||||||
| WBStrain00037828 | |||||||||
| WBStrain00051460 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00085504 | ||||||||
| 00085505 | |||||||||
| 00085506 | |||||||||
| 00085507 | |||||||||
| 00085508 | |||||||||
| 00085509 | |||||||||
| Ortholog (28) | |||||||||
| Paralog | WBGene00016706 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WBGene00010742 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00021415 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00000523 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00000526 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00000525 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | clc-1 encodes a claudin homolog, closely similar to CLC-2, that is required for normal cohesion of apical junctions in epithelia; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water; CLC-1 maintains the impermeability ('barrier function') of epithelia, since clc-1(RNAi) animals have abnormal permeability of the pharynx to dyes; clc-1 is expressed in spermatheca, pharynx, intestine, hypodermis, the excretory-secretory system, and the cell-cell junctions of the vulva; in pharyngeal cells, CLC-1 colocalizes with AJM-1 in long thin lines, parallel to the pharyngeal axis and lining the lumenal surface, that appear to correspond with apical intercellular junctions. | Paper_evidence | WBPaper00004961 | |||||
| WBPaper00005946 | |||||||||
| WBPaper00005975 | |||||||||
| WBPaper00012856 | |||||||||
| WBPaper00018356 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Involved in defense response to Gram-positive bacterium; epithelial cell-cell adhesion; and innate immune response. Located in cell-cell junction. Expressed in pharynx. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C09F12.1 | |||||||
| Corresponding_transcript | C09F12.1.1 | ||||||||
| C09F12.1.2 | |||||||||
| Other_sequence (11) | |||||||||
| Associated_feature | WBsf648512 | ||||||||
| WBsf663312 | |||||||||
| WBsf1006893 | |||||||||
| WBsf1006894 | |||||||||
| WBsf1023803 | |||||||||
| WBsf1023804 | |||||||||
| WBsf236329 | |||||||||
| WBsf236330 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00028726 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00094853 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00077666 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00085306 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00010522 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00040204 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00066881 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00085299 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00077664 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00001345 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr2559 | ||||||||
| Expr1019731 | |||||||||
| Expr1144274 | |||||||||
| Expr2010041 | |||||||||
| Expr2028282 | |||||||||
| Drives_construct | WBCnstr00010852 | ||||||||
| WBCnstr00037477 | |||||||||
| Construct_product | WBCnstr00010852 | ||||||||
| WBCnstr00037477 | |||||||||
| Antibody | WBAntibody00000649 | ||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (282) | |||||||||
| Interaction (87) | |||||||||
| Map_info | Map | X | Position | 2.85734 | Error | 0.000156 | |||
| Positive | Positive_clone | C09F12 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference (11) | |||||||||
| Remark | Sequence connection from [Asano A, Tsukita S] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
