WormBase Tree Display for Gene: WBGene00000525

WBGene00000525 Evidence: Person_evidence: WBPerson765
  SMap: S_parent: Sequence: T05A10
  Identity: Version: 1
    Name: CGC_name: clc-4
      Sequence_name: T05A10.2
      Molecular_name: T05A10.2
        T05A10.2.1
        CE03634
      Other_name: CELE_T05A10.2 Accession_evidence: NDB BX284606
      Public_name: clc-4
    DB_info: Database: AceView gene XL402
        WormQTL gene WBGene00000525
        WormFlux gene WBGene00000525
        NDB locus_tag CELE_T05A10.2
        Panther gene CAEEL|WormBase=WBGene00000525|UniProtKB=Q22191
          family PTHR37446
        NCBI gene 188095
        RefSeq protein NM_077399.2
        TREEFAM TREEFAM_ID TF316995
        TrEMBL UniProtAcc Q22191
        UniProt_GCRP UniProtAcc Q22191
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: clc
    Allele (14)
    Strain: WBStrain00036940
    RNASeq_FPKM (74)
    GO_annotation: 00074466
      00074467
    Ortholog (22)
    Paralog: WBGene00000522 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: clc-4 encodes a claudin homolog that may be required for normal cohesion of apical junctions in epithelia; CLC-4 is worm-specific, with obvious homologs only in C. elegans; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water. Paper_evidence: WBPaper00004961
            WBPaper00005946
            WBPaper00005975
            WBPaper00012856
            WBPaper00018356
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to be involved in epithelial cell-cell adhesion. Predicted to be located in membrane. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: T05A10.2
    Corresponding_transcript: T05A10.2.1
    Other_sequence: CRC02181_1
      CJC06228_1
      CR05828
    Associated_feature: WBsf1006818
      WBsf237891
  Experimental_info: RNAi_result: WBRNAi00112618 Inferred_automatically: RNAi_primary
      WBRNAi00035160 Inferred_automatically: RNAi_primary
      WBRNAi00018171 Inferred_automatically: RNAi_primary
      WBRNAi00052432 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1023488
      Expr1156053
      Expr2010044
      Expr2028285
    Drives_construct: WBCnstr00037474
    Construct_product: WBCnstr00037474
    Microarray_results (19)
    Expression_cluster (71)
    Interaction (58)
  Map_info: Map: X Position: 2.52829 Error: 0.004316
    Positive: Positive_clone: T05A10 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00005946
    WBPaper00013424
    WBPaper00013425
    WBPaper00018356
    WBPaper00039831
  Remark: Sequence connection from [Asano A, Tsukita S]
    Name exchange requested by Dr. Asano: clc-2 = C01C10.1 and clc-4 = T05A10.2 Person_evidence: WBPerson765
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene