acs-2 encodes an acyl-CoA synthetase; by homology, ACS-2 is predicted to catalyze conversion of a fatty acid to Acyl-CoA for subsequent beta oxidation; accordingly, loss of acs-2 activity via RNAi results in defects in fat metabolism; an ACS-2::GFP reporter fusion protein is widely expressed and appears to localize to mitochondria; acs-2 expression is positively regulated by the NHR-49 nuclear hormone receptor.
Predicted to enable medium-chain fatty acid-CoA ligase activity. Involved in fatty acid metabolic process. Located in mitochondrion. Expressed in body wall musculature; hypodermis; intestine; neurons; and pharynx. Is an ortholog of human ACSF2 (acyl-CoA synthetase family member 2).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.