WormBase Tree Display for Gene: WBGene00006467

WBGene00006467 SMap: S_parent: Sequence: C01B7
  Identity: Version: 4
    Name: CGC_name: magu-2 Person_evidence: WBPerson260
      Sequence_name: C01B7.4
      Molecular_name: C01B7.4a
        C01B7.4a.1
        CE52786
        C01B7.4b
        CE06728
        C01B7.4b.1
      Other_name: tag-117 Person_evidence: WBPerson51134
            WBPerson21950
        CELE_C01B7.4 Accession_evidence: NDB BX284605
      Public_name: magu-2
    DB_info: Database: AceView gene 5J272
        WormQTL gene WBGene00006467
        WormFlux gene WBGene00006467
        NDB locus_tag CELE_C01B7.4
        Panther gene CAEEL|WormBase=WBGene00006467|UniProtKB=A0A3B1DQX2
          family PTHR23122
        NCBI gene 3565703
        RefSeq protein NM_001368460.3
            NM_001392569.1
        TrEMBL UniProtAcc A0A3B1DQX2
            Q17549
        UniProt_GCRP UniProtAcc A0A3B1DQX2
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:40 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 07 Feb 2012 16:30:56 WBPerson2970 Name_change: CGC_name: magu-2
        3 17 Sep 2018 14:44:56 WBPerson4025 Event: Acquires_merge: WBGene00015276
        4 06 Sep 2021 12:29:06 WBPerson1983 Name_change: Other_name: tag-117
      Acquires_merge: WBGene00015276
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: magu
    Allele (111)
    Strain: WBStrain00001351
      WBStrain00031792
      WBStrain00035753
    RNASeq_FPKM (74)
    GO_annotation (15)
    Ortholog (38)
    Paralog: WBGene00002991 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00016841 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00021914 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
    Structured_description: Concise_description: magu-2 encodes a protein with similarity to the MAGUK (membrane-associated guanylate kinase) family of proteins; loss of magu-2 activity in large-scale RNAi screens can result in embryonic lethality with low, reproducible chromosome segregation defects; magu-2 exhibits genetic interactions with sem-5 and glp-1. Paper_evidence: WBPaper00025054
            WBPaper00031036
          Curator_confirmed: WBPerson1843
          Date_last_updated: 06 Jan 2011 00:00:00
      Automated_description: Predicted to be involved in several processes, including establishment or maintenance of cell polarity; morphogenesis of an epithelial sheet; and protein localization to plasma membrane. Predicted to be located in adherens junction and plasma membrane. Expressed in head; hypodermis; and pharyngeal muscle cell. Is an ortholog of human PALS1 (protein associated with LIN7 1, MAGUK p55 family member). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C01B7.4a
      C01B7.4b
    Corresponding_CDS_history: C01B7.4:wp267
    Corresponding_transcript: C01B7.4a.1
      C01B7.4b.1
    Other_sequence (25)
    Associated_feature: WBsf652873
      WBsf717246
      WBsf718362
      WBsf718363
      WBsf1000758
      WBsf1000759
      WBsf1000760
      WBsf1000761
      WBsf1020096
      WBsf1020097
  Experimental_info: RNAi_result: WBRNAi00028272 Inferred_automatically: RNAi_primary
      WBRNAi00067794 Inferred_automatically: RNAi_primary
      WBRNAi00077325 Inferred_automatically: RNAi_primary
      WBRNAi00039280 Inferred_automatically: RNAi_primary
      WBRNAi00009904 Inferred_automatically: RNAi_primary
      WBRNAi00067982 Inferred_automatically: RNAi_primary
      WBRNAi00009903 Inferred_automatically: RNAi_primary
      WBRNAi00103157 Inferred_automatically: RNAi_primary
      WBRNAi00028271 Inferred_automatically: RNAi_primary
      WBRNAi00039281 Inferred_automatically: RNAi_primary
    Expr_pattern (11)
    Drives_construct: WBCnstr00002244
      WBCnstr00028966
      WBCnstr00041995
    Construct_product: WBCnstr00028966
      WBCnstr00041995
    Regulate_expr_cluster: WBPaper00062554:MAGU-2_interacting
    Microarray_results (36)
    Expression_cluster: WBPaper00029359_1280
      WBPaper00029359_1444
      WBPaper00029359_1465
      WBPaper00029359_1504
      WBPaper00029359_1578
      WBPaper00029359_1604
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037055:DAF-16_binding_DNA
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_embryo_enriched
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_embryo_enriched
      WBPaper00037950:GABAergic-motor-neurons_embryo_SelectivelyEnriched
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038168:lin-15B(n744)_upregulated
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_downregulated_RNAseq
      WBPaper00040560:hpl-2_embryo_upregulated
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00044037:eat-2_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00045314:S.aureus-induced_N2
      WBPaper00045521:Oogenic
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049498:npr-1(ur89)_regulated_1
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_100-cell-embryo
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:arcade_intestinal-valve_enriched
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051137:Orsay-virus_upregulated_rde-1(ne219)
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053388:dauer_regulated_Cluster4
      WBPaper00053664:ins-11(tm1053)_upregulated
      WBPaper00053771:up_at_3h-NaCl
      WBPaper00053814:15C_downregulated_OP50
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00055565:AVK_enriched
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056284:ints-1(RNAi)_downregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056809:smn-1(ok355)_upregulated
      WBPaper00056826:hmc_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057068:ints-4(RNAi)_upregulated
      WBPaper00057143:ztf-11(RNAi)_upregulated
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058691:cfp-1(tm6369)_downregulated
      WBPaper00058691:sin-3(tm1276)_downregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059739:hira-1(gk835598)_upregulated_adult
      WBPaper00059839:S.maltophilia_regulated
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060014:set-2(zr2012)_downregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:ADA_ADE_grandparent
      WBPaper00061340:ADEsh
      WBPaper00061340:ADF_AWB
      WBPaper00061340:AMsh
      WBPaper00061340:ASG_AWA
      WBPaper00061340:ASK_parent
      WBPaper00061340:CEPsh
      WBPaper00061340:g1A_parent
      WBPaper00061340:Glia
      WBPaper00061340:hyp3
      WBPaper00061340:IL1_parent
      WBPaper00061340:ILsh_OLLsh_OLQsh
      WBPaper00061340:mc1
      WBPaper00061340:Neuroblast_ADF_AWB
      WBPaper00061340:OLL_parent
      WBPaper00061340:OLQ_parent
      WBPaper00061340:Parent_of_g1P_I3
      WBPaper00061340:Rectal_cell
      WBPaper00061340:RIV
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061466:nath-10(icb102)_upregulated
      WBPaper00061527:acy-2-F35C5.11
      WBPaper00061527:R07G3.8_9125-ric-4_17408
      WBPaper00061651:RME_DV_enriched
      WBPaper00061651:RME_LR_enriched
      WBPaper00061753:csr-1(tor159)_upregulated_25C
      WBPaper00062103:neuron_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062345:bortezomib_4h_upregulated_N2
      WBPaper00062345:bortezomib_4h_upregulated_zip-1(jy13)
      WBPaper00062446:nhr-8(hd117)_upregulated
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062590:Aging_upregulated_intestine
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064716:paraquat_upregulated
      WBPaper00064762:freezing-thaw_regulated
      WBPaper00064871:PA14_upregulated_AWA
      WBPaper00064939:vit-5(RNAi)_upregulated
      WBPaper00065086:JU1400_N.ausubeli_regulated
      WBPaper00065086:JU1400_N.ferruginous_regulated
      WBPaper00065086:JU1400_N.ironsii_regulated
      WBPaper00065086:JU1400_N.parisii_regulated
      WBPaper00065086:N2_N.ausubeli_regulated
      WBPaper00065086:N2_N.ferruginous_regulated
      WBPaper00065086:N2_N.ironsii_regulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065225:nhr-42(tm1375)_upregulated_S.aureus-infected
      WBPaper00065373:sek-1(km4)_downregulated_cisplatin
      WBPaper00065749:Heat-Shock-With-Recovery_upregulated_N2
      WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
      WBPaper00065835:Day11_vs_Day1_upregulated
      WBPaper00065841:49_0
      WBPaper00065841:50_0
      WBPaper00065841:109_0
      WBPaper00065841:118_0
      WBPaper00065841:130_0
      WBPaper00065841:132_0
      WBPaper00065975:P-body_vs_WholeAnimal_enriched
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00066232:hsf-1(RNAi)_upregulated_ash-2
      cgc4489_group_13
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00028789:PA14_vs_gacA_upregulated_4hr
      WBPaper00028789:PA14_vs_gacA_upregulated_8hr
      WBPaper00028789:PA14_vs_OP50_upregulated_4hr
      WBPaper00028789:PA14_vs_OP50_upregulated_8hr
      WBPaper00029437:dcr-1_upregulated
      WBPaper00031003:0hr_muscle_enriched
      WBPaper00031003:total_muscle_enriched
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00031532:Larva_Pan_Neuronal_Enriched
      WBPaper00032165:differentially_expressed_with_age_medoid_2
      WBPaper00034739:N2moreDR1350
      WBPaper00035084:embryo_enriched_AIN-2_IP
      WBPaper00035227:heat_shock_regulated
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00036123:Atrazine_regulated
      WBPaper00036130:mir-243_up_regulated
      WBPaper00037695:WC_5-day
      WBPaper00038231:Cry5B_1.5-fold_upregulated
      WBPaper00038231:Cry5B_2-fold_upregulated
      WBPaper00038304:octr-1_regulated
      WBPaper00041267:SpaceFlight_Downregulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00042067:Cu2+_upregulated_WT
      WBPaper00042548:miRISC_enriched
      WBPaper00042574:JU1580_OrsayVirus_upregulated
      WBPaper00044013:nasp-1_downregulated
      WBPaper00044091:Bpseudomallei_induced_4h
      WBPaper00044091:Bpseudomallei_induced_8h
      WBPaper00045673:colistin_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00048989:N2_rapamycin_upregulated
      WBPaper00051448:P.aeruginosa_Slow-Killing_upregulated
      WBPaper00055899:nitroguanidine_regulated
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5376]:let-60(G12V)-regulated_genes
      [cgc6390]:Cluster_B
    Interaction (65)
  Map_info: Map: V Position: 1.61461 Error: 0.004441
    Positive: Positive_clone: C01B7 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4356
    Pseudo_map_position
  Reference: WBPaper00031333
    WBPaper00035956
    WBPaper00038491
    WBPaper00051918
    WBPaper00055090
    WBPaper00058545
    WBPaper00059621
    WBPaper00062554
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
    Moved tag-117 from magu-1 to magu-2 where it belongs, seems like a very old (2013) misassignment.
  Method: Gene