magu-2 encodes a protein with similarity to the MAGUK (membrane-associated guanylate kinase) family of proteins; loss of magu-2 activity in large-scale RNAi screens can result in embryonic lethality with low, reproducible chromosome segregation defects; magu-2 exhibits genetic interactions with sem-5 and glp-1.
Predicted to be involved in several processes, including establishment or maintenance of cell polarity; morphogenesis of an epithelial sheet; and protein localization to plasma membrane. Predicted to be located in adherens junction and plasma membrane. Expressed in head; hypodermis; and pharyngeal muscle cell. Is an ortholog of human PALS1 (protein associated with LIN7 1, MAGUK p55 family member).