WormBase Tree Display for Gene: WBGene00005010
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| WBGene00005010 | Evidence | Paper_evidence | WBPaper00005525 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | Y40B1B | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | spr-5 | Person_evidence | WBPerson220 | |||||
| Sequence_name | Y40B1B.6 | ||||||||
| Molecular_name | Y40B1B.6 | ||||||||
| Y40B1B.6.1 | |||||||||
| CE20240 | |||||||||
| Y40B1B.6.2 | |||||||||
| Other_name | CELE_Y40B1B.6 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | spr-5 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:37 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | spr | ||||||||
| Allele (202) | |||||||||
| Strain | WBStrain00003899 | ||||||||
| WBStrain00005680 | |||||||||
| WBStrain00005722 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (22) | |||||||||
| Contained_in_operon | CEOP1700 | ||||||||
| Ortholog (42) | |||||||||
| Paralog | WBGene00000137 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00000138 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00011615 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00000139 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00016061 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00019154 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | spr-5 encodes H3K4me2 demethylase containing amine oxidase domain that functions to mediate chromatin remodeling and transcriptional regulation orthologous to human histone demethylase LSD1 (lysine-specific demethylase 1 (OMIM: 609132)); loss of spr-5 activity suppresses Egl phenotype of mutations in sel-12/presenilin and derepresses expression of hop-1, which encodes the second C. elegans presenilin; in spr-5 mutants lack of demethylase activity results in germline mortality due to epigenetic defect and is associated with defects in oogenesis and spermatogenesis as well late larval growth delay; sterility in spr-5 mutants is due to retention of H3K4me2 in the PGCs; spr-5 mutants exhibit transgene desilencing in the germline, suggesting that all spermatogenesis-expressed genes are coordinately misregulated; in spr-5 there is heritable accumulation of spermatogenesis-enriched expression due to heritable accumulation of H3K4me2; outcrossing at severely sterile generations rescues the sterility defect of spr-5; SPR-5 interacts with SPR-1, the C. elegans ortholog of CoREST;spr-5 is expressed in all stages, but it is enriched in the adult and highly expressed in the gonad. | Paper_evidence | WBPaper00005525 | |||||
| WBPaper00005564 | |||||||||
| WBPaper00033101 | |||||||||
| Curator_confirmed | WBPerson12884 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 22 Aug 2011 00:00:00 | ||||||||
| Automated_description | Enables FAD-dependent H3K4me/H3K4me3 demethylase activity. Involved in epigenetic regulation of gene expression. Located in cytoplasm and nucleus. Expressed in germ line. Human ortholog(s) of this gene implicated in several diseases, including alopecia areata; diabetic retinopathy; and hepatocellular carcinoma. Is an ortholog of human KDM1A (lysine demethylase 1A). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:986 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:29079) | ||||
| DOID:8947 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:29079) | ||||||
| DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:29079) | ||||||
| DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:29079) | ||||||
| Molecular_info | Corresponding_CDS | Y40B1B.6 | |||||||
| Corresponding_transcript | Y40B1B.6.1 | ||||||||
| Y40B1B.6.2 | |||||||||
| Other_sequence (12) | |||||||||
| Associated_feature | WBsf985868 | ||||||||
| WBsf1011076 | |||||||||
| WBsf218735 | |||||||||
| WBsf218736 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00004611 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00089593 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00091519 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00022756 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00089623 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00056320 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00036977 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr2274 | ||||||||
| Expr8609 | |||||||||
| Expr1015205 | |||||||||
| Expr1032494 | |||||||||
| Expr1159808 | |||||||||
| Expr2016092 | |||||||||
| Expr2034327 | |||||||||
| Construct_product | WBCnstr00020449 | ||||||||
| WBCnstr00039711 | |||||||||
| Regulate_expr_cluster | WBPaper00033101:spr-5_regulated | ||||||||
| WBPaper00060886:spr-5(by101);met-2(n4256)_downregulated | |||||||||
| WBPaper00060886:spr-5(by101);met-2(n4256)_upregulated | |||||||||
| WBPaper00060886:spr-5(by101)_downregulated | |||||||||
| WBPaper00060886:spr-5(by101)_upregulated | |||||||||
| Antibody | WBAntibody00001911 | ||||||||
| WBAntibody00001912 | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (100) | |||||||||
| Interaction (81) | |||||||||
| WBProcess | WBbiopr:00000014 | ||||||||
| Map_info | Map | I | Position | 20.7399 | Error | 0.137006 | |||
| Positive | Positive_clone | Y40B1B | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4694 | |||||||
| 5003 | |||||||||
| 5554 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (63) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
