WormBase Tree Display for Gene: WBGene00011615
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| WBGene00011615 | SMap | S_parent | Sequence | T08D10 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | lsd-1 | |||||||
| Sequence_name | T08D10.2 | ||||||||
| Molecular_name | T08D10.2 | ||||||||
| T08D10.2.1 | |||||||||
| CE33174 | |||||||||
| Other_name | CELE_T08D10.2 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | lsd-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:52 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 27 Nov 2007 15:26:11 | WBPerson2970 | Name_change | CGC_name | lsd-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lsd | ||||||||
| Allele (54) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (20) | |||||||||
| Ortholog (31) | |||||||||
| Paralog | WBGene00000137 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00000138 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00005010 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00000139 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00016061 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00019154 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | lsd-1 encodes an ortholog of the human histone demethylase LSD1 (KIAA0601), and a paralog of C. elegans SPR-5; similar histone demethylase homologs are found in human, mouse, Drosophila, fission yeast, and Arabidopsis; LSD-1 is predicted to demethylate histone H3 lysine 4 residues and act as a transcriptional corepressor. | Paper_evidence | WBPaper00028307 | |||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 18 Jul 2005 00:00:00 | ||||||||
| Automated_description | Predicted to enable chromatin binding activity; flavin adenine dinucleotide binding activity; and oxidoreductase activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Predicted to be located in membrane and nucleus. Human ortholog(s) of this gene implicated in several diseases, including alopecia areata; diabetic retinopathy; and hepatocellular carcinoma. Is an ortholog of human KDM1A (lysine demethylase 1A). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:986 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:29079) | ||||
| DOID:8947 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:29079) | ||||||
| DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:29079) | ||||||
| DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:29079) | ||||||
| Molecular_info | Corresponding_CDS | T08D10.2 | |||||||
| Corresponding_CDS_history | T08D10.2:wp93 | ||||||||
| Corresponding_transcript | T08D10.2.1 | ||||||||
| Associated_feature | WBsf1007144 | ||||||||
| WBsf1023952 | |||||||||
| WBsf236431 | |||||||||
| WBsf236432 | |||||||||
| WBsf236433 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00008243 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00091521 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00089624 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00106173 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00052857 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00018437 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00089594 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1022571 | ||||||||
| Expr1035118 | |||||||||
| Expr1156458 | |||||||||
| Expr2013287 | |||||||||
| Expr2031518 | |||||||||
| Drives_construct | WBCnstr00030527 | ||||||||
| Construct_product | WBCnstr00030527 | ||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (156) | |||||||||
| Interaction | WBInteraction000310930 | ||||||||
| WBInteraction000319194 | |||||||||
| WBInteraction000357298 | |||||||||
| WBInteraction000464246 | |||||||||
| WBInteraction000503379 | |||||||||
| WBInteraction000555499 | |||||||||
| WBInteraction000566473 | |||||||||
| WBInteraction000566752 | |||||||||
| WBInteraction000574667 | |||||||||
| Map_info | Map | X | Position | 6.76339 | |||||
| Positive | Positive_clone | T08D10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (13) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
