WormBase Tree Display for Gene: WBGene00004986

WBGene00004986 SMap: S_parent: Sequence: T07C4
  Identity: Version: 1
    Name: CGC_name: spp-1
      Sequence_name: T07C4.4
      Molecular_name: T07C4.4
        T07C4.4.1
        CE35363
      Other_name: CELE_T07C4.4 Accession_evidence: NDB BX284603
      Public_name: spp-1
    DB_info: Database: AceView gene 3L444
        WormQTL gene WBGene00004986
        WormFlux gene WBGene00004986
        NDB locus_tag CELE_T07C4.4
        NCBI gene 176452
        RefSeq protein NM_066889.8
        TREEFAM TREEFAM_ID TF322432
        TrEMBL UniProtAcc Q22291
        UniProt_GCRP UniProtAcc Q22291
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:37 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: spp
    Allele: WBVar01500260
      WBVar01499545
      WBVar00407186
      WBVar01499774
      WBVar02019092
      WBVar00093807
      WBVar00252252
      WBVar00855993
    Strain: WBStrain00032729
    RNASeq_FPKM (74)
    GO_annotation (14)
    Contained_in_operon: CEOP3839
    Ortholog (22)
    Paralog: WBGene00004997 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
    Structured_description: Concise_description: spp-1 encodes a caenopore, a saposin (B) domain-containing protein that is a member of the saposin-like protein (SAPLIP) superfamily containing mammalian NK-lysin and granulysin and the protozoan amoebapore-like proteins; SPP-1 exhibits antibacterial activity in vitro and its expression in vivo is regulated by the DAF-2/insulin receptor signaling pathway and by the presence of bacterial pathogens such as Salmonella typhimurium and Pseudomonas aeruginosa; an spp-1::gfp reporter fusion is expressed in the intestine. Paper_evidence: WBPaper00003435
            WBPaper00005976
            WBPaper00029438
            WBPaper00031463
            WBPaper00032276
            WBPaper00035289
            WBPaper00041035
          Curator_confirmed: WBPerson1843
          Date_last_updated: 05 Jul 2012 00:00:00
      Automated_description: Enables pore-forming activity. Involved in defense response to other organism and pore formation in membrane of another organism. Part of pore complex. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: T07C4.4
    Corresponding_CDS_history: T07C4.4:wp108
    Corresponding_transcript: T07C4.4.1
    Other_sequence: CR10745
      CBC10698_1
      CRC07559_1
    Associated_feature: WBsf227443
  Experimental_info: RNAi_result (34)
    Expr_pattern: Expr4718
      Expr8002
      Expr1020872
      Expr1032482
      Expr1156337
      Expr2016075
      Expr2034311
    Drives_construct: WBCnstr00012195
      WBCnstr00035291
    Construct_product: WBCnstr00012195
      WBCnstr00035291
    Microarray_results (25)
    Expression_cluster: WBPaper00028802:intestine_unique
      WBPaper00033065:clk-1(qm30)_upregulated
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00033065:isp-1-1(qm150)_upregulated
      WBPaper00033070:Elbe_upregulated
      WBPaper00036291:ung-1_regulated
      WBPaper00036738:4uM_Heme_downregulated
      WBPaper00037950:intestine_larva_enriched
      WBPaper00037950:intestine_larva_SelectivelyEnriched
      WBPaper00038168:lin-15B(n744)_downregulated
      WBPaper00038438:P.lumniescens_24hr_downregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_downregulated_TilingArray
      WBPaper00040285:H2S_24hr_upregulated
      WBPaper00042561:smgl-1(RNAi)_downregulated
      WBPaper00044030:nhr-8(hd117)_downregulated
      WBPaper00044246:pgrn-1_ced-3_downregulated
      WBPaper00044316:CH3HgCl_7.5uM_downregulated
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045314:S.aureus-induced_N2
      WBPaper00045401:N.parisii_64h_downregulated
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_upregulated
      WBPaper00045729:gld-2(RNAi)_upregulated
      WBPaper00045774:clk-1_upregulated
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00047132:glp-1(ts)-25C_upregulated
      WBPaper00048971:daf-16(mgDf50)_downregulated_L1
      WBPaper00048988:neuron_expressed
      WBPaper00049334:CE_intestine_enriched
      WBPaper00049484:elt-2(RNAi)_downregulated_L1
      WBPaper00049484:elt-2(RNAi)_downregulated_L4
      WBPaper00049498:npr-1(ur89)_regulated_8
      WBPaper00049545:cco-1(RNAi)_downregulated
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
      WBPaper00049920:hyl-2(tm2031)_downregulated
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00049954:BPA_downregulated
      WBPaper00050121:mir-60(n4947)_upregulated
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_24-cell-embryo
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_100-cell-embryo
      WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo
      WBPaper00050163:chd-3(eh4)_downregulated_100-cell-embryo
      WBPaper00050332:skn-1(RNAi)_downregulated
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050412:cco-1(RNAi)_downregulated_N2
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00051039:intestine_enriched
      WBPaper00051265:F4_hrde-1(tm1200)_downregulated
      WBPaper00051265:F4_morc-1(tm6048)_downregulated
      WBPaper00051305:vit-2(ac3)_downregulated
      WBPaper00051404:alg-2(ok304)_downregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053092:procyanidins_downregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053318:Aging_upregulated_mRNA_N2
      WBPaper00053318:mir-71(n4115)_upregulated_mRNA
      WBPaper00053388:dauer_regulated_Cluster3
      WBPaper00053599:female_vs_male_downregulated
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_downregulated
      WBPaper00053606:N2_vs_elt-2(ca15)_downregulated
      WBPaper00053713:Pheromone-induced_postdauer_vs_control_downregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00054758:alg-1(gk204)_downregulated
      WBPaper00055103:thoc-5(wy822)_downregulated
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Psora_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin-Psora_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055626:pry-1(mu38)_upregulated
      WBPaper00055827:daf-2(e1370)_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056034:pals-25(jy9)_upregulated
      WBPaper00056039:hda-6(ok3203)_upregulated
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056167:Cry5B_upregulated
      WBPaper00056167:ifo-1(kc2)_upregulated
      WBPaper00056275:P.aeruginosa_downregulated
      WBPaper00056275:P.aeruginosa_downregulated_atf-7(qd22qd130)_dependent
      WBPaper00056284:ints-2(RNAi)_downregulated
      WBPaper00056290:hsp-6(mg585)_upregulated
      WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected
      WBPaper00056443:DietaryRestriction_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay1
      WBPaper00056826:hmc_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057068:Cadmium_downregulated
      WBPaper00057265:metaformin_upregulated_OP50
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058665:graphene-oxide_downregulated_mRNA
      WBPaper00058711:paraquat_downregulated
      WBPaper00058711:wdr-5(ok1417)_downregulated
      WBPaper00059604:fluvastatin_upregulated_dlk-1(km12)
      WBPaper00059604:fluvastatin_upregulated_N2
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059735:glucose_downregulated_lpin-1(RNAi)
      WBPaper00059739:hira-1(gk835598)_downregulated_adult
      WBPaper00059739:hira-1(gk835598)_downregulated_L4
      WBPaper00059839:S.maltophilia_regulated
      WBPaper00060100:SiNP_downregulated_mRNA
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060683:hlh-11(overexpression)_downregulated
      WBPaper00061274:microgravity_downregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061390:daf-22(ok693)_ascarosides_downregulated
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061527:R10H10.3-T21H3.1
      WBPaper00061527:sre-33-ZK1025.1_8337
      WBPaper00061530:nhr-49(e2144)_downregulated
      WBPaper00061590:CGP37157_downregulated
      WBPaper00061651:Intestine_enriched
      WBPaper00061753:csr-1(tor159)_upregulated_25C
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00061952:daf-18(nr2037)_downregulated
      WBPaper00062056:lin-35(n745)_downregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062446:nhr-8(hd117)_downregulated
      WBPaper00062446:nhr-8(ok186)_downregulated
      WBPaper00062520:qui-1(db104)_upregulated
      WBPaper00062585:hlh-26(ok1453)_downregulated_E.faecium
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064005:starvation_upregulated_N2_mRNA
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064156:lbp-3(overexpress)_upregulated
      WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
      WBPaper00064505:tamoxifen_downregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064769:him-17(me24)_downregulated
      WBPaper00064871:hypoxia_downregulated_F2
      WBPaper00064992:heat-shock_upregulated
      WBPaper00065086:JU1400_N.ausubeli_regulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065392:Lb.delbrueckii_downregulated
      WBPaper00065392:Lb.gasseri_downregulated
      WBPaper00065392:Lb.plantarum_downregulated
      WBPaper00065392:Lb.reuteri_downregulated
      WBPaper00065392:Lb.rhamnosus_downregulated
      WBPaper00065392:P.pentosaceus_downregulated
      WBPaper00065749:Heat-Shock-With-Recovery_downregulated_N2
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065835:mtH2S-AP39-D0-treatment_upregulated_Day5
      WBPaper00065835:mtH2S-AP39-D0-treatment_upregulated_Day11
      WBPaper00065841:3_0
      WBPaper00065841:3_1
      WBPaper00065841:3_2
      WBPaper00065841:3_5
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      cgc4386_cluster_1_2
      cgc4489_group_12
      WBPaper00025141:unc-4::GFP_Enriched_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00028482:PA14_downregulated
      WBPaper00029437:rde-4_upregulated
      WBPaper00030839:Embryo_A_Class
      WBPaper00031703:heme_responsive_4
      WBPaper00032165:A_to_C_transit_decreased
      WBPaper00032165:differentially_expressed_with_age_medoid_4
      WBPaper00032948:StarveUp3
      WBPaper00034757:up_by_oxidative_stress
      WBPaper00035873:osm-8_regulated
      WBPaper00036286:Pattern_D
      WBPaper00037113:Chlorpyrifos_Diazinon_16C_regulated
      WBPaper00037113:CPF_16C_down-regulated
      WBPaper00037147:heatshock_downregulated
      WBPaper00038060:SUMO-1_downregulated
      WBPaper00038172:tax-6null_down_regulated
      WBPaper00038231:Cry5B_1.5-fold_downregulated
      WBPaper00038304:octr-1_regulated
      WBPaper00038462:aging_downregulated
      WBPaper00040426:CYD-1_CDK-4_downregulated
      WBPaper00040823:alg-1(gk214)_upregulated
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_old
      WBPaper00040858:eQTL_regulated_reproductive
      WBPaper00040963:Q100_up
      WBPaper00040963:Q200_up
      WBPaper00041002:HQ_3d_2.0mM_Up
      WBPaper00041174:environmental
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_and_environmental
      WBPaper00041211:RPW-24_Down
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_24h
      WBPaper00041939:control_vs_EtBr-exposed_51h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00044091:Bpseudomallei_regulated_qPCR-confirmed
      WBPaper00044091:Bpseudomallei_repressed_12h
      WBPaper00045263:0.1mM-paraquat_downregulated
      WBPaper00045263:isp-1(qm150)_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00045673:colistin_upregulated
      WBPaper00046548:dafachronic-acid_upregulated
      WBPaper00046853:AOBr_M.aeruginosa-batch-culture_upregulated
      WBPaper00048624:hlh-25(ok1710)_downregulated
      WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_ET
      [cgc5767]:expression_class_ET_max(66_min)
      [cgc5767]:expression_class_E_pi(66_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc5767]:expression_class_MET
    Interaction (20)
    WBProcess: WBbiopr:00000008
      WBbiopr:00000039
  Map_info: Map: III Position: 2.4671 Error: 0.002388
    Positive: Positive_clone: T07C4 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (34)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene