WBGene00004862 | Evidence | Paper_evidence | WBPaper00013343 |
| SMap | S_parent | Sequence | T05A10 |
| Identity | Version | 1 |
| | Name | CGC_name | sma-9 | Person_evidence | WBPerson261 |
| | | Sequence_name | T05A10.1 |
| | | Molecular_name (38) |
| | | Other_name | CELE_T05A10.1 | Accession_evidence | NDB | BX284606 |
| | | Public_name | sma-9 |
| | DB_info | Database (12) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | sma |
| | Allele (216) |
| | Legacy_information | [Savage-Dunn C] Small and Mab (sensory ray and spicule abnormalities). |
| | Complementation_data | [Savage-Dunn C] complements sma-5(n678) |
| | Strain (18) |
| | RNASeq_FPKM (74) |
| | GO_annotation (41) |
| | Contained_in_operon | CEOPX001 |
| | Ortholog (43) |
| | Structured_description | Concise_description | sma-9 encodes, by extensive alternative splicing, at least 13 isoforms, a number of which are large (~2000-residue) proteins with at least three N-terminal involucrin domains, seven C-terminal zinc-finger domains, and a glutamine/asparagine-rich domain; SMA-9 is orthologous to the Drosophila Smad cofactor Schnurri (FBgn0003396) and the vertebrate HIVEP proteins (Human Immunodeficiency Virus Type 1 Enhancer-Binding Proteins, OMIM:194540, OMIM:143054, and OMIM:606649); in C. elegans, sma-9 functions in a subset of the TGF-beta-mediated signaling pathways that regulate body size and male tail patterning and morphogenesis; sma-9, through this pathway, also regulates reproductive aging; studies have shown that a reduction of TGF-beta pathway genes extends reproductive span by maintaining oocyte and germline quality; sma-9 also functions antagonistically to the TGF-beta signaling pathway, and in parallel to the lin-12/Notch pathway, to effect proper cell fate specification in the postembryonic mesodermal lineage, the M lineage; SMA-9 is widely expressed and localizes to nuclei. | Paper_evidence | WBPaper00005858 |
| | | | | | WBPaper00006346 |
| | | | | | WBPaper00027702 |
| | | | | | WBPaper00029226 |
| | | | | | WBPaper00035079 |
| | | | | | WBPaper00035556 |
| | | | | | WBPaper00037682 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson324 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 18 Jan 2011 00:00:00 |
| | | Automated_description | Enables transcription coactivator activity and transcription corepressor activity. Involved in several processes, including determination of adult lifespan; nematode male tail tip morphogenesis; and regulation of gene expression. Acts upstream of or within cellular response to heat. Located in nucleus. Expressed in several structures, including excretory cell; intestine; spermatheca; ventral cord neurons; and vulva. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 43. Is an ortholog of human HIVEP1 (HIVEP zinc finger 1); HIVEP2 (HIVEP zinc finger 2); and HIVEP3 (HIVEP zinc finger 3). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:10652 | Homo sapiens | Paper_evidence | WBPaper00046027 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 21 Sep 2018 00:00:00 |
| | Potential_model | DOID:0070073 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4921) |
| Models_disease_in_annotation | WBDOannot00000341 |
| Molecular_info | Corresponding_CDS (11) |
| | Corresponding_CDS_history (13) |
| | Corresponding_transcript (16) |
| | Other_sequence (328) |
| | Associated_feature (25) |
| | Gene_product_binds (41) |
| | Transcription_factor | WBTranscriptionFactor000847 |
| Experimental_info | RNAi_result (21) |
| | Expr_pattern | Expr2782 |
| | | Expr2783 |
| | | Expr3995 |
| | | Expr10436 |
| | | Expr1011744 |
| | | Expr1032413 |
| | | Expr1156052 |
| | | Expr1200018 |
| | | Expr2015897 |
| | | Expr2034130 |
| | Drives_construct (15) |
| | Construct_product (11) |
| | Antibody | WBAntibody00000885 |
| | Microarray_results (83) |
| | Expression_cluster | WBPaper00028867:HLH-1_induced_TF |
| | | WBPaper00032976:dosage_compensated_genes |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037055:DAF-16_binding_DNA |
| | | WBPaper00037682:sma-2_sma-4_upregulated |
| | | WBPaper00037946:EGL-5_interacting |
| | | WBPaper00038438:Harposporium_24hr_downregulated_RNAseq |
| | | WBPaper00040209:B.thuringiensis_upregulated_MY18 |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00040285:H2S_12hr_downregulated |
| | | WBPaper00042215:wdr-23(tm1817)_upregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044743:wdr-23_neuron_upregulated |
| | | WBPaper00045314:S.aureus-induced_N2 |
| | | WBPaper00045316:prg-1_upregulated_L1 |
| | | WBPaper00045316:prg-1_upregulated_L2 |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045974:NSM_enriched_DSN-treated_RNAseq |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00046741:Garlic-Extract_upregulated_mRNA |
| | | WBPaper00046805:csr-1(RNAi)_downregulated_Set1 |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049217:DAF-16_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031) |
| | | WBPaper00049942:HeatShock_downregulated_hsf-1(+) |
| | | WBPaper00050015:ifg-1(RNAi)_upregulated |
| | | WBPaper00050234:lin-28(RNAi)_upregulated |
| | | WBPaper00050370:dpy-21(e428)_L3_upregulated |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:daf-2(e1370)_vs_daf-2(e1370);mir-34(gk437)_regulated_dauer_25C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053023:nlg-1(ok259)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(icb38)_upregulated |
| | | WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053599:mitosis_vs_meiosis_downregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00053810:daf-2(e1370)_upregulated |
| | | WBPaper00055060:flr-1(RNAi)_upregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055344:hypoxia_regulated_HIF-1_independent |
| | | WBPaper00055482:pmt-2(RNAi)_upregulated |
| | | WBPaper00055897:heat-shock_downregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056161:hermaphrodite_enriched_siRNA |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056868:P.aeruginosa_upregulated_smallRNA |
| | | WBPaper00057041:unc-70(cas983)_downregulated |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058691:WDR-5.1_interacting_protein |
| | | WBPaper00058725:sftb-1(cer6)_downregulated |
| | | WBPaper00058725:sftb-1(cer39)_downregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059567:olrn-1(ums9)_regulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061340:G2_and_W_blasts |
| | | WBPaper00061439:unc-30(ok613)_downregulated |
| | | WBPaper00061478:SUMO-conjugated_protein |
| | | WBPaper00061479:HDA-1_interacting_protein |
| | | WBPaper00061527:chd-7_16664-jmjd-3.1 |
| | | WBPaper00061527:ldb-1_2877-scd-1_3086 |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062193:skn-1(RNAi)_downregulated |
| | | WBPaper00064005:starvation_upregulated_aptf-1(gk794)_mRNA |
| | | WBPaper00064005:starvation_upregulated_N2_mRNA |
| | | WBPaper00064055:trl-1(cas1077)_upregulated_non-starved |
| | | WBPaper00064055:trl-1(cas1077)_upregulated_starved |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064122:vulva_transcriptome |
| | | WBPaper00064156:lbp-3(overexpress)_upregulated |
| | | WBPaper00064315:mes-3(bn199)_upregulated_EGCs |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064939:vit-5(RNAi)_upregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065199:Transgeneration-starvation_regulated_fed |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | cgc4386_cluster_6_5 |
| | | cgc4489_group_15 |
| | | cgc4489_group_20 |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_upregulated |
| | | WBPaper00025032:cluster_10 |
| | | WBPaper00025032:cluster_12 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00029437:dcr-1_upregulated |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00032948:StarveUp2 |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00035227:heat_shock_regulated |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00037113:CPF_DZN_16C_up-regulated |
| | | WBPaper00038060:SUMO-1_downregulated |
| | | WBPaper00040823:alg-1(gk214)_downregulated |
| | | WBPaper00040858:eQTL_age_regulated_aging |
| | | WBPaper00040858:eQTL_age_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_juvenile |
| | | WBPaper00040858:eQTL_regulated_old |
| | | WBPaper00040963:Q100_down |
| | | WBPaper00040963:Q200_down |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00041960:N2_fasting_upregulated_anytime |
| | | WBPaper00045865:biofilm_upregulated_A |
| | | WBPaper00045960:L4-lethargus_upregulated |
| | | WBPaper00047070:N2_starvation_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00048989:N2_allantoin_downregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | WBPaper00055899:nitroguanidine_regulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(122_min) |
| | | [cgc5767]:expression_class_SE |
| | | [cgc5767]:expression_class_SE_pi(122_min) |
| | | [cgc6390]:male_soma-enriched |
| | Interaction (82) |
| | WBProcess | WBbiopr:00000025 |
| | | WBbiopr:00000026 |
| | | WBbiopr:00000033 |
| Map_info | Map | X | Position | 2.51785 | Error | 0.028298 |
| | Positive | Inside_rearr | nDf19 |
| | | | yDp9 |
| | | Positive_clone | T05A10 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Negative | Outside_rearr | mnDp1 |
| | | | mnDf1 |
| | | | yDp5 |
| | Mapping_data | 2_point | 7096 |
| | | | 7097 |
| | | | 7099 |
| | | Pos_neg_data | 10243 |
| | | | 10244 |
| | | | 10245 |
| | | | 10246 |
| | | | 10247 |
| Reference (61) |
| Picture | WBPicture0000013077 |
| Method | Gene |