WormBase Tree Display for Gene: WBGene00004350

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WBGene00004350	SMap	S_parent	Sequence	F56B6
	Identity	Version	2
		Name	CGC_name	rgs-7	Person_evidence	WBPerson330
			Sequence_name	F56B6.2
			Molecular_name (27)
			Other_name	CELE_F56B6.2	Accession_evidence	NDB	BX284606
			Public_name	rgs-7
		DB_info	Database	AceView	gene	XE175
				WormQTL	gene	WBGene00004350
				WormFlux	gene	WBGene00004350
				NDB	locus_tag	CELE_F56B6.2
				Panther	gene	CAEEL\|WormBase=WBGene00004350\|UniProtKB=Q8WQC0
					family	PTHR10845
				NCBI	gene	180645
				RefSeq	protein	NM_001129682.5
						NM_001373262.3
						NM_001373261.4
						NM_001374994.1
						NM_001029543.5
						NM_001129681.4
						NM_001373260.4
						NM_001029544.6
						NM_076209.7
				SwissProt	UniProtAcc	Q8WQC0
				TrEMBL	UniProtAcc	A0A4V0IJG9
						Q1W0R0
						H2KYQ7
						A0A4V0IKM4
						A0A4V0ILX5
						H2KYQ8
				UniProt_GCRP	UniProtAcc	Q8WQC0
		Species	Caenorhabditis elegans
		History	Version_change	1	07 Apr 2004 11:29:35	WBPerson1971	Event	Imported	Initial conversion from geneace
				2	03 Dec 2004 16:13:27	WBPerson2970	Event	Acquires_merge	WBGene00018936
			Acquires_merge	WBGene00018936
		Status	Live
	Gene_info	Biotype	SO:0001217
		Gene_class	rgs
		Allele	WBVar00275085	Inferred_automatically	From strain object: LX658
			WBVar00275090	Inferred_automatically	From strain object: LX677
			WBVar01134624
			WBVar01134625
			WBVar01134626
			WBVar01134627
			WBVar01134628
			WBVar01134629
			WBVar01134630
			WBVar00499323
			WBVar01134631
			WBVar00499324
			WBVar01134632
			WBVar01134633
			WBVar00499325
			WBVar01134634
			WBVar00499326
			WBVar01134635
			WBVar00499327
			WBVar01914193
			WBVar00499328
			WBVar01134636
			WBVar02121347
			WBVar00499329
			WBVar01134637
			WBVar01498609
			WBVar00499330
			WBVar01134638
			WBVar00499331
			WBVar01134639
			WBVar01134640
			WBVar00499332
			WBVar00499333
			WBVar01825060
			WBVar01134641
			WBVar00499334
			WBVar01134642
			WBVar01825061
			WBVar00499335
			WBVar01134643
			WBVar01134644
			WBVar00499336
			WBVar01134645
			WBVar00499337
			WBVar01134646
			WBVar00499338
			WBVar00499339
			WBVar01830094
			WBVar01134647
			WBVar00499340
			WBVar01134648
			WBVar00499341
			WBVar01544459
			WBVar01134649
			WBVar00499342
			WBVar01134650
			WBVar00499343
			WBVar00499344
			WBVar00499345
			WBVar00499346
			WBVar00499347
			WBVar00499348
			WBVar00077144
			WBVar00499349
			WBVar00499350
			WBVar00499351
			WBVar00093672
			WBVar00069879
			WBVar02026935
			WBVar01486700
			WBVar01498854
			WBVar01814062
			WBVar01814063
			WBVar01814064
			WBVar01980165
			WBVar01980166
			WBVar01134523
			WBVar01980167
			WBVar01134524
			WBVar01134525
			WBVar01134526
			WBVar01134527
			WBVar01134528
			WBVar01134529
			WBVar01134530
			WBVar01134531
			WBVar01134532
			WBVar01134533
			WBVar01134534
			WBVar01134535
			WBVar01134536
			WBVar01134537
			WBVar01134538
			WBVar02151154
			WBVar01134539
			WBVar01134540
			WBVar01134541
			WBVar01134542
			WBVar01134543
			WBVar01134544
			WBVar01134545
			WBVar01134546
			WBVar01134547
			WBVar01134548
			WBVar01134549
			WBVar01134550
			WBVar02001140
			WBVar01134551
			WBVar01134552
			WBVar01134553
			WBVar01134554
			WBVar01134555
			WBVar01134556
			WBVar01134557
			WBVar01134558
			WBVar01134559
			WBVar01499636
			WBVar01134560
			WBVar01134561
			WBVar01134562
			WBVar01134563
			WBVar01134564
			WBVar01134565
			WBVar01134566
			WBVar01134567
			WBVar01134568
			WBVar01134569
			WBVar01134570
			WBVar01786826
			WBVar01134571
			WBVar01134572
			WBVar01134573
			WBVar01134574
			WBVar02055369
			WBVar01134575
			WBVar01134576
			WBVar01134577
			WBVar01134578
			WBVar01134579
			WBVar01134580
			WBVar01134581
			WBVar01134582
			WBVar01134583
			WBVar00266417
			WBVar01134584
			WBVar01134585
			WBVar01134586
			WBVar01134587
			WBVar01134588
			WBVar01134589
			WBVar01134590
			WBVar01134591
			WBVar01134592
			WBVar01134593
			WBVar01134594
			WBVar01134595
			WBVar01134596
			WBVar01134597
			WBVar01619525
			WBVar01134598
			WBVar01134599
			WBVar01134600
			WBVar01134601
			WBVar01468311
			WBVar01134602
			WBVar01468312
			WBVar01134603
			WBVar01468313
			WBVar01134604
			WBVar02122052
			WBVar01468314
			WBVar01134605
			WBVar01468315
			WBVar01134606
			WBVar01134607
			WBVar01134608
			WBVar01134609
			WBVar01134610
			WBVar01134611
			WBVar01134612
			WBVar02139035
			WBVar01134613
			WBVar01134614
			WBVar02139036
			WBVar01134615
			WBVar01134616
			WBVar01134617
			WBVar01134618
			WBVar01134619
			WBVar01134620
			WBVar01134621
			WBVar01134622
			WBVar01134623
			WBVar01500067
		Strain	WBStrain00026370
			WBStrain00026372
			WBStrain00032622
			WBStrain00034758
		RNASeq_FPKM (74)
		GO_annotation	00021823
			00021824
			00021825
			00085200
			00085201
		Ortholog (38)
		Paralog (12)
		Structured_description	Concise_description	rgs-7 encodes three isoforms of an atypical regulator of G protein signaling (RGS) protein that contains both a C2 and an RGS domain, and that binds EGL-30 via both domains, similar in organization to mammalian PDZ-RGS3; the RGS domain has GTPase activator protein (GAP) activity in vitro on mammalian G[alphai]3; RGS-7 thus may stably bind EGL-30 at all stages of EGL-30's GTPase cycle, might organize EGL-30 into a stable multiprotein signalling complex (with GTP[gamma]S), and might persistently inhibit EGL-30 when triggered by calcium or phospholipids; rgs-7 has no obvious function in mass RNAi assays	Paper_evidence	WBPaper00005654
						WBPaper00005958
						WBPaper00013066
					Curator_confirmed	WBPerson567
					Date_last_updated	18 Jun 2007 00:00:00
			Automated_description	Enables GTPase activator activity. Predicted to be involved in negative regulation of signal transduction. Located in cell cortex. Is an ortholog of several human genes including RGS1 (regulator of G protein signaling 1); RGS13 (regulator of G protein signaling 13); and RGS4 (regulator of G protein signaling 4).	Paper_evidence	WBPaper00065943
					Curator_confirmed	WBPerson324
						WBPerson37462
					Inferred_automatically	This description was generated automatically by a script based on data from the WS291 version of WormBase
					Date_last_updated	29 Nov 2023 00:00:00
	Molecular_info	Corresponding_CDS	F56B6.2a
			F56B6.2b
			F56B6.2c
			F56B6.2e
			F56B6.2f
			F56B6.2g
			F56B6.2h
			F56B6.2i
			F56B6.2j
		Corresponding_CDS_history	F56B6.2d:wp271
		Corresponding_transcript	F56B6.2a.1
			F56B6.2b.1
			F56B6.2c.1
			F56B6.2e.1
			F56B6.2f.1
			F56B6.2g.1
			F56B6.2h.1
			F56B6.2i.1
			F56B6.2j.1
		Other_sequence (21)
		Associated_feature (27)
	Experimental_info	RNAi_result	WBRNAi00048645	Inferred_automatically	RNAi_primary
			WBRNAi00048644	Inferred_automatically	RNAi_primary
			WBRNAi00032932	Inferred_automatically	RNAi_primary
			WBRNAi00015785	Inferred_automatically	RNAi_primary
		Expr_pattern	Expr3108
			Expr1025711
			Expr1032168
			Expr1152407
			Expr1200208
			Expr2015330
			Expr2033564
		Drives_construct	WBCnstr00011142
			WBCnstr00035547
		Construct_product	WBCnstr00011142
			WBCnstr00035547
		Microarray_results	SMD_F56B6.2
			SMD_F56B6.3
			174784_at
			180987_at
			192158_at
			A_12_P102863
			A_12_P175082
			A_12_P175083
			A_12_P175084
			A_12_P175085
			Aff_F56B6.2
			Aff_F56B6.3
			GPL13394_WBGene00004350
			GPL13914_F56B6.2
			GPL14144_F56B6.2a_2044-2103_0.923_7_C
			GPL14144_F56B6.2a_2154-2213_0.941_1_A
			GPL14144_F56B6.2a_2336-2395_0.931_4_B
			GPL19516_CGZ0024518
			GPL19516_CGZ0024519
			GPL19516_CGZ0024520
			GPL19516_CGZ0024521
			GPL19516_CGZ0024522
			GPL19516_CGZ0024523
			GPL19516_CGZ0024524
			GPL21109_F56B6.2a
			GPL3518_CE29403
			GPL3518_CE29404
			GPL8304_CE_WBGene00004350_A
			GPL8304_CE_WBGene00004350_B
			GPL8673_F56B6_2aP01033
			GPL8673_F56B6_2aP01527
			GPL8673_F56B6_2aP01858
			GPL8673_F56B6_2bP00922
			GPL8673_F56B6_2bP01416
			GPL8673_F56B6_2bP01747
			GPL8673_F56B6_2cP00342
			GPL8673_F56B6_2cP00527
			GPL8673_F56B6_2cP00673
			GPL8673_F56B6_2dP00060
			GPL8673_F56B6_2dP00143
			GPL8673_F56B6_2dP00564
			GPL8673_F56B6_2eP00042
			GPL8673_F56B6_2eP00227
			GPL8673_F56B6_2eP00373
			GPL9450_F56B6.2a
			GPL9450_F56B6.2b
			GPL9450_F56B6.2c
			cea2.3.16772
			cea2.3.16781
			cea2.3.16795
			cea2.d.04044
			cea2.d.07952
			cea2.d.29145
		Expression_cluster	WBPaper00028788:MPK-1_Response_Medium
			WBPaper00031040:TGF-beta_adult_downregulated
			WBPaper00033065:cyc-1(RNAi)_downregulated
			WBPaper00035211:age-1_vs_N2_downregulated
			WBPaper00037682:sma-2_upregulated
			WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
			WBPaper00037950:bodywall-muscle_L1-larva_expressed
			WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
			WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
			WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
			WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
			WBPaper00037950:hypodermis_L1-larva_expressed
			WBPaper00037950:hypodermis_L3-L4-larva_expressed
			WBPaper00037950:intestine_L1-larva_expressed
			WBPaper00037950:intestine_L2-larva_expressed
			WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
			WBPaper00037950:PVD-OLL-neurons_larva_enriched
			WBPaper00037950:PVD-OLL-neurons_larva_SelectivelyEnriched
			WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
			WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
			WBPaper00044736:flat_dev_expression
			WBPaper00045420:fertilization_downregulated_transcript
			WBPaper00045521:Oogenic
			WBPaper00045729:gld-2(RNAi)_downregulated
			WBPaper00045974:NSM_enriched_DSN-treated_RNAseq
			WBPaper00045974:NSM_enriched_totalRNA_RNAseq
			WBPaper00045974:NSM_enriched_totalRNA_tiling
			WBPaper00048988:neuron_expressed
			WBPaper00049545:jmjd-3.1(+)_upregulated
			WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
			WBPaper00049905:Age_variant_expression
			WBPaper00049942:hsf-1(RNAi)_upregulated
			WBPaper00050344:AFD-neuron_enriched
			WBPaper00050370:dpy-21(e428)_L3_upregulated
			WBPaper00050488:adult_vs_dauer_regulated_N2_20C
			WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
			WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
			WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
			WBPaper00050990:arcade_intestinal-valve_expressed
			WBPaper00050990:hypodermis_expressed
			WBPaper00050990:intestine_expressed
			WBPaper00051039:germline_enriched
			WBPaper00053184:sma-4(rax3)_downregulated
			WBPaper00053289:DREAM-target
			WBPaper00053302:alovudine_72h_regulated
			WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
			WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq
			WBPaper00053388:dauer_regulated_Cluster1
			WBPaper00053599:female_vs_male_upregulated
			WBPaper00053599:oocyte_vs_mitosis_downregulated
			WBPaper00055334:DLC-1_interacting
			WBPaper00055386:daf-2(e1370)_downregulated
			WBPaper00055804:FBF-1-FBF-2-associated_oogenic-enriched
			WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
			WBPaper00056161:hermaphrodite_enriched_siRNA
			WBPaper00056218:daf-16(mu86)_upregulated_Day7
			WBPaper00056275:P.aeruginosa_downregulated
			WBPaper00056275:P.aeruginosa_downregulated_atf-7(qd22qd130)_dependent
			WBPaper00056275:P.aeruginosa_downregulated_pmk-1(km25)_dependent
			WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
			WBPaper00057288:Cold_downregulated_transcript
			WBPaper00057288:iff-1(RNAi)_downregulated_transcript
			WBPaper00059356:BAZ-2_SET-6_interacting
			WBPaper00059471:EGL-43_interacting
			WBPaper00059567:olrn-1(ums9)_regulated
			WBPaper00059754:C.neoformans_H99_upregulated
			WBPaper00059763:neuron_expressed
			WBPaper00060100:SiNP_upregulated_mRNA
			WBPaper00060278:atp-2(RNAi)_upregulated
			WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
			WBPaper00060683:hlh-11(ko1)_downregulated
			WBPaper00060811:L1_vs_adult_upregulated_neural
			WBPaper00061007:HB101_downregulated
			WBPaper00061340:ABarpaaa_lineage
			WBPaper00061340:ASK
			WBPaper00061340:CEPsh
			WBPaper00061340:RIA
			WBPaper00061527:nrde-3-tra-4_10484
			WBPaper00061527:R07E4.5-skp-1_1608
			WBPaper00061527:utx-1_2886-swan-1_2192
			WBPaper00061651:ASK_enriched
			WBPaper00061651:I1_enriched
			WBPaper00061651:NSM_enriched
			WBPaper00061651:OLL_enriched
			WBPaper00061651:PHB_enriched
			WBPaper00061651:RIA_enriched
			WBPaper00061651:RMD_DV_enriched
			WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
			WBPaper00062159:hda-2(ok1479)_downregulated
			WBPaper00062590:Aging_upregulated_body-wall-muscle
			WBPaper00064315:mes-4(bn73)_upregulated_EGCs
			WBPaper00064716:paraquat_upregulated
			WBPaper00065835:Day11_vs_Day1_upregulated
			WBPaper00065841:40_0
			WBPaper00065841:52_0
			WBPaper00065841:53_0
			WBPaper00065841:63_0
			WBPaper00065841:83_0
			WBPaper00065841:116_0
			WBPaper00065975:P-body_vs_oocyte_enriched
			WBPaper00065975:P-body_vs_WholeAnimal_enriched
			WBPaper00065993:glp-1(e2141)_downregulated
			WBPaper00066110:Doxorubicin_downregulated_diploid
			WBPaper00066110:tetraploid_vs_diploid_downregulated
			cgc4489_group_5
			WBPaper00025032:cluster_13
			WBPaper00025141:unc-4::GFP_Expressed_Genes
			WBPaper00026929:Resveratrol_regulated_daf-16
			WBPaper00026929:sir-2.1_overexpression_regulated
			WBPaper00031003:0hr_muscle_depleted
			WBPaper00031003:total_muscle_depleted
			WBPaper00031252:AIN-1_IP_enriched
			WBPaper00031252:AIN-2_IP_enriched
			WBPaper00034661:AgNPs_downregulated
			WBPaper00035588:alg-1(-)_upregulated
			WBPaper00037695:CC_3-day
			WBPaper00038172:tax-6null_up_regulated
			WBPaper00040210:Chlorpyrifos_24C_regulated
			WBPaper00040858:eQTL_age_regulated_developing
			WBPaper00040858:eQTL_regulated_developing
			WBPaper00040858:eQTL_regulated_juvenile
			WBPaper00040858:eQTL_regulated_old
			WBPaper00040963:Q50_down
			WBPaper00040963:Q100_down
			WBPaper00040963:Q200_down
			WBPaper00040985:AIN-2_L4_intestine
			WBPaper00041267:SpaceFlight_Downregulated
			WBPaper00041606:CE_X.nematophila_regulated
			WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
			WBPaper00041939:control_vs_UVC-exposed_24h
			WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h
			WBPaper00042236:flcn-1(ok975)_upregulated
			WBPaper00045263:0.1mM-paraquat_upregulated
			WBPaper00045263:isp-1(qm150)_upregulated
			WBPaper00045263:nuo-6(qm200)_upregulated
			WBPaper00045263:ProLongevity-mtROS_upregulated
			WBPaper00045960:L4-lethargus_upregulated
			WBPaper00051448:P.aeruginosa_Slow-Killing_upregulated
			WBPaper00055899:nitroguanidine_regulated
			WBPaper00057098:SiO2-nanoparticles_upregulated
			[cgc5376]:let-60(G12V)-regulated_genes
			[cgc5767]:expression_class_E
			[cgc5767]:expression_class_E_pi(23_min)
			[cgc5767]:expression_class_E_pi(53_min)
			[cgc5767]:expression_class_M
			[cgc5767]:expression_class_ME
			[cgc6390]:Cluster_E
		Interaction (11)
		WBProcess	WBbiopr:00000017
	Map_info	Map	X	Position	-10.1117	Error	0.033929
		Positive	Positive_clone	F56B6	Inferred_automatically	From sequence, transcript, pseudogene data
		Mapping_data	Multi_point	5042
		Pseudo_map_position
	Reference (17)
	Remark	Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.	CGC_data_submission
	Method	Gene