rbf-1 encodes the sole C. elegans rabphilin homolog; rbf-1 activity is required for normal basal rates of locomotion (in the absence of stimulation) and, in combination with SNARE components ric-4, snb-1, and unc-64, for normal rates of both basal and stimulated locomotion; RBF-1 is expressed in the nerve ring and in the dorsal and ventral nerve cords and colocalizes with synaptic vesicle markers.
Predicted to enable metal ion binding activity. Involved in dense core granule exocytosis and positive regulation of locomotion. Located in synaptic vesicle. Expressed in dorsal nerve cord; nerve ring; neurons; and ventral nerve cord. Is an ortholog of human RPH3A (rabphilin 3A).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.