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WormBase Tree Display for Gene: WBGene00003774

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Name Class

WBGene00003774SMapS_parentSequenceF07F6
IdentityVersion1
NameCGC_namenmr-1Person_evidenceWBPerson404
Sequence_nameF07F6.6
Molecular_nameF07F6.6
F07F6.6.1
CE30128
Other_nameF56D1.bCurator_confirmedWBPerson1983
RemarkOld cosmid naming mapped via unique overlapping PCR_product on CDSs
F56D1.cCurator_confirmedWBPerson1983
RemarkOld cosmid naming mapped via unique overlapping PCR_product on CDSs
CELE_F07F6.6Accession_evidenceNDBBX284602
Public_namenmr-1
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:32WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classnmr
Allele (99)
StrainWBStrain00040167
WBStrain00002755
WBStrain00040168
WBStrain00040666
WBStrain00040171
WBStrain00040796
WBStrain00054658
WBStrain00054659
RNASeq_FPKM (74)
GO_annotation (32)
Ortholog (37)
ParalogWBGene00001612Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00001613Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00001614Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00001615Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00001616Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00001617Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00001618Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00001619Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00003775Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00012190Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionnmr-1 encodes an NMDA-type ionotropic glutamate receptor subunit that affects the duration of forward movement which is important during foraging behavior, and also affects osmotic avoidance; the slow kinetics typical of NMDA-dependent currents are likely important for its effect on forward movement.Paper_evidenceWBPaper00004836
WBPaper00005622
Curator_confirmedWBPerson48
Date_last_updated04 Mar 2005 00:00:00
Automated_descriptionPredicted to enable ligand-gated monoatomic ion channel activity and signaling receptor activity. Predicted to contribute to NMDA glutamate receptor activity. Involved in locomotory behavior and regulation of forward locomotion. Located in neuron projection; plasma membrane; and synapse. Expressed in several structures, including ganglia; gonadal sheath cell; head mesodermal cell; nerve ring neurons; and oocyte. Used to study neurodegenerative disease. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; alcohol use disorder; autosomal dominant intellectual developmental disorder 8; and developmental and epileptic encephalopathy 101. Is an ortholog of human GRIN1 (glutamate ionotropic receptor NMDA type subunit 1).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:1289Homo sapiensPaper_evidenceWBPaper00057034
Curator_confirmedWBPerson324
Date_last_updated30 Mar 2021 00:00:00
Potential_modelDOID:10652Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:4584)
DOID:0070038Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:4584)
DOID:8725Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:4584)
DOID:0070387Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:4584)
DOID:3526Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:4584)
DOID:1574Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:4584)
DOID:11206Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:4584)
Models_disease_assertedWBDOannot00000907
WBDOannot00000908
Molecular_infoCorresponding_CDSF07F6.6
Corresponding_transcriptF07F6.6.1
Other_sequenceOden_isotig22559
JI250035.1
Tcol_isotig18961
Associated_featureWBsf987884
WBsf987885
WBsf1012228
WBsf1012229
WBsf223054
Experimental_infoRNAi_resultWBRNAi00022320Inferred_automaticallyRNAi_primary
WBRNAi00043920Inferred_automaticallyRNAi_primary
WBRNAi00030612Inferred_automaticallyRNAi_primary
Expr_pattern (11)
Drives_construct (42)
Construct_productWBCnstr00000022
WBCnstr00006168
WBCnstr00010811
WBCnstr00011656
WBCnstr00013203
WBCnstr00035874
Microarray_results (19)
Expression_clusterWBPaper00032528:L3_depleted
WBPaper00037950:AVE-neuron_embryo_enriched
WBPaper00037950:AVE-neuron_embryo_SelectivelyEnriched
WBPaper00037950:germline-precursors_blastula-embryo_expressed
WBPaper00037950:glr-1(+)-neurons_larva_enriched
WBPaper00037950:glr-1(+)-neurons_larva_SelectivelyEnriched
WBPaper00037950:hypodermis_L1-larva_expressed
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
WBPaper00038438:Harposporium_24hr_upregulated_RNAseq
WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
WBPaper00038438:S.marcescens_24hr_downregulated_RNAseq
WBPaper00040285:H2S_12hr_downregulated
WBPaper00042194:nhr-114(RNAi)_downregulated
WBPaper00042215:wdr-23(tm1817)_upregulated
WBPaper00044743:wdr-23_neuron_upregulated
WBPaper00047131:daf-2(e1370)_upregulated_N2-background
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_enriched
WBPaper00048988:neuron_expressed
WBPaper00050370:dpy-21(e428)_L3_downregulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050726:OsmoticStress_regulated_NoFood
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00052856:Cadmium_regulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
WBPaper00054758:alg-1(gk204)_upregulated
WBPaper00055103:thoc-5(wy822)_upregulated
WBPaper00055226:adr-1(tm668)_upregulated
WBPaper00055354:eat-2(ad1116)_downregulated
WBPaper00055354:Psora-Allantoin_downregulated
WBPaper00055354:Rapamycin-Allantoin_downregulated
WBPaper00055354:Rapamycin-Metformin_downregulated
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
WBPaper00055354:Rapamycin_downregulated
WBPaper00055354:Rifampicin-Allantoin_downregulated
WBPaper00058711:skn-1(lax188)_upregulated
WBPaper00058948:PA14_downregulated
WBPaper00058969:RIS_depleted
WBPaper00059027:neuron-synapses_depleted
WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00059987:Wounding_upregulated
WBPaper00060014:set-2(tm1630)_downregulated
WBPaper00060459:bcat-1(RNAi)_upregulated
WBPaper00060661:sensory-neuron_enriched
WBPaper00060764:swsn-1(os22ts)_upregulated
WBPaper00060811:L1_vs_adult_upregulated_neural
WBPaper00060909:atfs-1(cmh15)_downregulated
WBPaper00061340:AVA
WBPaper00061340:mu_sph
WBPaper00061340:RMD
WBPaper00061341:28C_24h_upregulated
WBPaper00061341:28C_48h_upregulated
WBPaper00061424:Diet_MYb120_upregulated
WBPaper00061527:ckr-1-T09B9.3
WBPaper00061651:AVD_enriched
WBPaper00061995:mter-4(syb3662syb3403)_downregulated
WBPaper00062103:neuron_enriched
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062456:doxycycline_upregulated_CB4856_protein
WBPaper00062456:doxycycline_upregulated_N2_protein
WBPaper00062585:hlh-26(ok1453)_upregulated_E.faecium
WBPaper00062590:Aging_downregulated_neuron
WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064721:fasn-1(g14)_downregulated_starved
WBPaper00065096:25C_vs_20C_downregulated
WBPaper00065841:22_0
WBPaper00065841:49_0
WBPaper00065841:61_0
WBPaper00065841:73_0
WBPaper00065841:98_0
WBPaper00065841:102_0
WBPaper00065841:118_0
WBPaper00065841:120_0
WBPaper00065841:131_0
cgc4489_group_9
WBPaper00026929:Resveratrol_regulated_daf-16
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00030839:Larval_Pan_Neuronal
WBPaper00031252:AIN-1_IP_enriched
WBPaper00031252:AIN-2_IP_enriched
WBPaper00036123:Cadmium_regulated
WBPaper00040858:eQTL_regulated_old
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00048989:N2_rapamycin_downregulated
Interaction (71)
Map_infoMapIIPosition-1.52008Error0.016815
PositivePositive_cloneF07F6Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point4253
4538
5279
Pseudo_map_position
Reference (105)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene