WormBase Tree Display for Gene: WBGene00001612
expand all nodes | collapse all nodes | view schema
| WBGene00001612 | SMap | S_parent | Sequence | C06E1 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | glr-1 | Person_evidence | WBPerson42 | |||||
| Sequence_name | C06E1.4 | ||||||||
| Molecular_name | C06E1.4 | ||||||||
| C06E1.4.1 | |||||||||
| CE31407 | |||||||||
| Other_name | not-3 | ||||||||
| CELE_C06E1.4 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | glr-1 | ||||||||
| DB_info | Database | AceView | gene | 3J674 | |||||
| WormQTL | gene | WBGene00001612 | |||||||
| WormFlux | gene | WBGene00001612 | |||||||
| NDB | locus_tag | CELE_C06E1.4 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00001612|UniProtKB=P34299 | |||||||
| family | PTHR18966 | ||||||||
| NCBI | gene | 176204 | |||||||
| RefSeq | protein | NM_066486.8 | |||||||
| SwissProt | UniProtAcc | P34299 | |||||||
| UniProt_GCRP | UniProtAcc | P34299 | |||||||
| OMIM | gene | 138244 | |||||||
| 138248 | |||||||||
| 305915 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | glr | ||||||||
| Allele (57) | |||||||||
| Legacy_information | [C.elegansII] n2461 : fails to respond to light nose touch (Not),or to harsh body touch (Tab); other sensory responses normal. n2461/Df similar.ME3. Missense mutation. OA1: ky176te,sd(non-null deletion, Not, Mec; slightly sluggish; other sensory responses normal; ky176/+ Not, Mec). Cloned: encodes predicted 962 aa protein with similarity to AMPA-class glutamate receptors(40% identity to rat GluRB). glr-1:GFP expressed in 17 neuron classes. [Maricq et al. 1995; Hart et al. 1995; CX; KP] | ||||||||
| [Hart AC] Not, Tab. n2461 is nonsense mutation in codon 807 of GLR-1, glutamate receptor. Predicted gene C06E1.4 | |||||||||
| Strain (50) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (73) | |||||||||
| Ortholog (64) | |||||||||
| Paralog | WBGene00001613 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00001619 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00001617 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00001616 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00001615 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00001614 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00001618 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00003774 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00003775 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00012190 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | glr-1 encodes an AMPA-type ionotropic glutamate receptor; GLR-1 activity is required for mediating the behavioral response to light nose touch and the frequency with which animals change locomotory direction in response to sensory cues such as food; GLR-1 is also required for memory formation; GLR-1 and GLR-2, a second AMPA-type ionotropic glutamate receptor, can interact to form functional heteromeric channels; GLR-1 is expressed in motorneurons and interneurons, including four of the five pairs of command interneurons that are required for locomotory control; in the ventral nerve cord and nerve ring, GLR-1 localizes to perinuclear structures in cell bodies and to punctate structures that appear to be glutamatergic postsynaptic specializations; proper GLR-1 localization in the anterior ventral nerve cord of older larvae and adults requires activity of the class I PDZ protein LIN-10; GLR-1 is ubiquitinated in vivo and its abundance at postsynaptic elements, which may influence postsynaptic strength, is regulated by ubiquitination; indeed, GLR-1 trafficking in interneurons has been shown to be regulated by the UEV-1 ubiquitin-conjugating enzyme variant and the UBC-13 ubiquitin-conjugating enzyme; GLR-1 dynamics are also regulated by the alpha-adducin, ADD-1, which may link actin cytoskeleton reorganization with synapse structure and composition. | Paper_evidence | WBPaper00002308 | |||||
| WBPaper00003214 | |||||||||
| WBPaper00004567 | |||||||||
| WBPaper00005349 | |||||||||
| WBPaper00006375 | |||||||||
| WBPaper00037956 | |||||||||
| WBPaper00038120 | |||||||||
| WBPaper00040733 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Feb 2012 00:00:00 | ||||||||
| Automated_description | Enables enzyme binding activity and ionotropic glutamate receptor activity. Involved in several processes, including forward locomotion; learning or memory; and positive regulation of locomotion. Located in several cellular components, including perinuclear endoplasmic reticulum; postsynapse; and somatodendritic compartment. Part of ionotropic glutamate receptor complex. Expressed in interneuron; neurons; and ventral nerve cord. Used to study neurodegenerative disease. Human ortholog(s) of this gene implicated in several diseases, including Huntington's disease; childhood absence epilepsy; and intellectual disability (multiple). Is an ortholog of human GRIA2 (glutamate ionotropic receptor AMPA type subunit 2) and GRIA3 (glutamate ionotropic receptor AMPA type subunit 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:1289 | Homo sapiens | Paper_evidence | WBPaper00057034 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 30 Mar 2021 00:00:00 | ||||||||
| Potential_model | DOID:0060307 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4571) | |||||
| DOID:1825 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4579) | ||||||
| DOID:0081182 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4580) | ||||||
| DOID:12858 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4580) | ||||||
| DOID:0060823 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4573) | ||||||
| DOID:0081235 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4571) | ||||||
| DOID:5419 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4574,HGNC:4579) | ||||||
| Models_disease_asserted | WBDOannot00000909 | ||||||||
| WBDOannot00000914 | |||||||||
| Molecular_info | Corresponding_CDS | C06E1.4 | |||||||
| Corresponding_CDS_history | C06E1.4:wp82 | ||||||||
| Corresponding_transcript | C06E1.4.1 | ||||||||
| Other_sequence (23) | |||||||||
| Associated_feature | WBsf651289 | ||||||||
| WBsf651290 | |||||||||
| WBsf667164 | |||||||||
| WBsf993406 | |||||||||
| WBsf1015458 | |||||||||
| WBsf227147 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00039890 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00005523 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027649 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00010303 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (24) | |||||||||
| Drives_construct (135) | |||||||||
| Construct_product (31) | |||||||||
| Antibody | WBAntibody00000399 | ||||||||
| WBAntibody00000430 | |||||||||
| WBAntibody00001575 | |||||||||
| WBAntibody00001624 | |||||||||
| WBAntibody00001644 | |||||||||
| WBAntibody00001792 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (171) | |||||||||
| Interaction (149) | |||||||||
| Anatomy_function | WBbtf0671 | ||||||||
| WBProcess | WBbiopr:00000002 | ||||||||
| WBbiopr:00000054 | |||||||||
| Map_info | Map | III | Position | -0.245417 | Error | 0.001615 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | nDf20 | |||||||
| Positive_clone | C06E1 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Negative | Outside_rearr | sDp3 | |||||||
| Mapping_data | Multi_point | 4740 | |||||||
| Pos_neg_data | 9418 | ||||||||
| 9419 | |||||||||
| Reference (341) | |||||||||
| Remark | Data extracted from Hart et al. (1995) | ||||||||
| Method | Gene |
