WormBase Tree Display for Gene: WBGene00003775
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| WBGene00003775 | SMap | S_parent | Sequence | CHROMOSOME_V | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | nmr-2 | Person_evidence | WBPerson404 | |||||
| Sequence_name | T01C3.10 | ||||||||
| Molecular_name | T01C3.10a | ||||||||
| T01C3.10a.1 | |||||||||
| CE46168 | |||||||||
| T01C3.10b | |||||||||
| CE45268 | |||||||||
| T01C3.10b.1 | |||||||||
| Other_name | CELE_T01C3.10 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | nmr-2 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:32 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | nmr | ||||||||
| Allele (78) | |||||||||
| Strain | WBStrain00037456 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (24) | |||||||||
| Contained_in_operon | CEOP5436 | ||||||||
| Ortholog (49) | |||||||||
| Paralog | WBGene00001612 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| WBGene00001613 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00001614 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00001615 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00001616 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00001617 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00001618 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00001619 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00003774 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00012190 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | nmr-2 encodes an ionotropic glutamate receptor (iGluR) subunit that is most similar to members of the NR2A subfamily of the NMDA class of iGluRs; genetic analysis indicates that nmr-2 is required for full memory retention of a learned avoidance behavior, namely avoidance of NaCl after starvation conditioning; in addition, NMR-2 activity is required for NMDA-gated currents in the AVA interneuron; an NMR-2::GFP fusion protein is expressed in the AVA, AVD, AVE, RIM, AVG, and PVC interneurons beginning at the three-fold stage of embryogenesis; NMR-2::GFP expression is coincident with that of NMR-1, a second C. elegans NMDA-type ionotropic glutamate receptor subunit also required for memory retention; nmr-2 expression in AVA and AVE is positively regulated by the FAX-1 nuclear receptor. | Paper_evidence | WBPaper00004567 | |||||
| WBPaper00026828 | |||||||||
| WBPaper00031974 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 13 Jan 2009 00:00:00 | ||||||||
| Automated_description | Predicted to enable NMDA glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission and modulation of chemical synaptic transmission. Predicted to be located in postsynaptic density membrane. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Huntington's disease; epilepsy (multiple); and gastrointestinal system cancer (multiple). Is an ortholog of human GRIN2C (glutamate ionotropic receptor NMDA type subunit 2C). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (17) | ||||||||
| Molecular_info | Corresponding_CDS | T01C3.10a | |||||||
| T01C3.10b | |||||||||
| Corresponding_CDS_history | T01C3.10:wp76 | ||||||||
| T01C3.10:wp188 | |||||||||
| T01C3.10a:wp227 | |||||||||
| Corresponding_transcript | T01C3.10a.1 | ||||||||
| T01C3.10b.1 | |||||||||
| Other_sequence (19) | |||||||||
| Associated_feature | WBsf653424 | ||||||||
| WBsf235015 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00052093 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00044661 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00082466 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00082638 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr825 | ||||||||
| Expr1019248 | |||||||||
| Expr1031764 | |||||||||
| Expr1155724 | |||||||||
| Expr2014333 | |||||||||
| Expr2032574 | |||||||||
| Drives_construct | WBCnstr00006175 | ||||||||
| WBCnstr00013210 | |||||||||
| WBCnstr00035873 | |||||||||
| Construct_product | WBCnstr00006175 | ||||||||
| WBCnstr00013210 | |||||||||
| WBCnstr00035873 | |||||||||
| Microarray_results (17) | |||||||||
| Expression_cluster (82) | |||||||||
| Interaction (53) | |||||||||
| Map_info | Map | V | Position | 7.1501 | Error | 0.004478 | |||
| Positive | Positive_clone | T01C3 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference (34) | |||||||||
| Remark | Sequence connection from [Petcherski A] krb 02/04/05 | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
