WormBase Tree Display for Gene: WBGene00001612
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WBGene00001612 | SMap | S_parent | Sequence | C06E1 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | glr | ||||||
Allele (57) | |||||||
Legacy_information | [C.elegansII] n2461 : fails to respond to light nose touch (Not),or to harsh body touch (Tab); other sensory responses normal. n2461/Df similar.ME3. Missense mutation. OA1: ky176te,sd(non-null deletion, Not, Mec; slightly sluggish; other sensory responses normal; ky176/+ Not, Mec). Cloned: encodes predicted 962 aa protein with similarity to AMPA-class glutamate receptors(40% identity to rat GluRB). glr-1:GFP expressed in 17 neuron classes. [Maricq et al. 1995; Hart et al. 1995; CX; KP] | ||||||
[Hart AC] Not, Tab. n2461 is nonsense mutation in codon 807 of GLR-1, glutamate receptor. Predicted gene C06E1.4 | |||||||
Strain (50) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (73) | |||||||
Ortholog (64) | |||||||
Paralog | WBGene00001613 | Caenorhabditis elegans | From_analysis | TreeFam | |||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00001619 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00001617 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00001616 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00001615 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00001614 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00001618 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00003774 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00003775 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00012190 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
Structured_description | Concise_description | glr-1 encodes an AMPA-type ionotropic glutamate receptor; GLR-1 activity is required for mediating the behavioral response to light nose touch and the frequency with which animals change locomotory direction in response to sensory cues such as food; GLR-1 is also required for memory formation; GLR-1 and GLR-2, a second AMPA-type ionotropic glutamate receptor, can interact to form functional heteromeric channels; GLR-1 is expressed in motorneurons and interneurons, including four of the five pairs of command interneurons that are required for locomotory control; in the ventral nerve cord and nerve ring, GLR-1 localizes to perinuclear structures in cell bodies and to punctate structures that appear to be glutamatergic postsynaptic specializations; proper GLR-1 localization in the anterior ventral nerve cord of older larvae and adults requires activity of the class I PDZ protein LIN-10; GLR-1 is ubiquitinated in vivo and its abundance at postsynaptic elements, which may influence postsynaptic strength, is regulated by ubiquitination; indeed, GLR-1 trafficking in interneurons has been shown to be regulated by the UEV-1 ubiquitin-conjugating enzyme variant and the UBC-13 ubiquitin-conjugating enzyme; GLR-1 dynamics are also regulated by the alpha-adducin, ADD-1, which may link actin cytoskeleton reorganization with synapse structure and composition. | Paper_evidence | WBPaper00002308 | |||
WBPaper00003214 | |||||||
WBPaper00004567 | |||||||
WBPaper00005349 | |||||||
WBPaper00006375 | |||||||
WBPaper00037956 | |||||||
WBPaper00038120 | |||||||
WBPaper00040733 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 17 Feb 2012 00:00:00 | ||||||
Automated_description | Enables enzyme binding activity and ionotropic glutamate receptor activity. Involved in several processes, including forward locomotion; learning or memory; and positive regulation of locomotion. Located in several cellular components, including perinuclear endoplasmic reticulum; postsynapse; and somatodendritic compartment. Part of ionotropic glutamate receptor complex. Expressed in interneuron; neurons; and ventral nerve cord. Used to study neurodegenerative disease. Human ortholog(s) of this gene implicated in several diseases, including Huntington's disease; childhood absence epilepsy; and intellectual disability (multiple). Is an ortholog of human GRIA2 (glutamate ionotropic receptor AMPA type subunit 2) and GRIA3 (glutamate ionotropic receptor AMPA type subunit 3). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:1289 | Homo sapiens | Paper_evidence | WBPaper00057034 | ||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 30 Mar 2021 00:00:00 | ||||||
Potential_model | DOID:0060307 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4571) | |||
DOID:1825 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4579) | ||||
DOID:0081182 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4580) | ||||
DOID:12858 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4580) | ||||
DOID:0060823 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4573) | ||||
DOID:0081235 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4571) | ||||
DOID:5419 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4574,HGNC:4579) | ||||
Models_disease_asserted | WBDOannot00000909 | ||||||
WBDOannot00000914 | |||||||
Molecular_info | Corresponding_CDS | C06E1.4 | |||||
Corresponding_CDS_history | C06E1.4:wp82 | ||||||
Corresponding_transcript | C06E1.4.1 | ||||||
Other_sequence (23) | |||||||
Associated_feature | WBsf651289 | ||||||
WBsf651290 | |||||||
WBsf667164 | |||||||
WBsf993406 | |||||||
WBsf1015458 | |||||||
WBsf227147 | |||||||
Experimental_info | RNAi_result | WBRNAi00039890 | Inferred_automatically | RNAi_primary | |||
WBRNAi00005523 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00027649 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00010303 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern (24) | |||||||
Drives_construct (135) | |||||||
Construct_product (31) | |||||||
Antibody | WBAntibody00000399 | ||||||
WBAntibody00000430 | |||||||
WBAntibody00001575 | |||||||
WBAntibody00001624 | |||||||
WBAntibody00001644 | |||||||
WBAntibody00001792 | |||||||
Microarray_results (19) | |||||||
Expression_cluster (171) | |||||||
Interaction (149) | |||||||
Anatomy_function | WBbtf0671 | ||||||
WBProcess | WBbiopr:00000002 | ||||||
WBbiopr:00000054 | |||||||
Map_info | Map | III | Position | -0.245417 | Error | 0.001615 | |
Well_ordered | |||||||
Positive | Inside_rearr | nDf20 | |||||
Positive_clone | C06E1 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||
Negative | Outside_rearr | sDp3 | |||||
Mapping_data | Multi_point | 4740 | |||||
Pos_neg_data | 9418 | ||||||
9419 | |||||||
Reference (341) | |||||||
Remark | Data extracted from Hart et al. (1995) | ||||||
Method | Gene |