WormBase Tree Display for Gene: WBGene00003730
expand all nodes | collapse all nodes | view schema
WBGene00003730 | SMap | S_parent | Sequence | B0495 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | nhx | ||||||
Allele (34) | |||||||
Strain | WBStrain00035710 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (35) | |||||||
Ortholog (49) | |||||||
Paralog | WBGene00003729 | Caenorhabditis elegans | From_analysis | TreeFam | |||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00003736 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00003733 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00003735 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00003731 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00003943 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00003734 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
Inparanoid_8 | |||||||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00003732 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
Structured_description | Concise_description | nhx-2 encodes a sodium/proton exchanger; NHX-2 promotes normal peptide transporter function and recovery from intracellular acid load via catalysis of the electroneutral exchange of extracellular sodium for an intracellular proton; NHX-2 activity is required for normally high growth rates, and for propagation or maintenance of the germline; NHX-2 is expressed in the apical membranes of intestinal cells. | Paper_evidence | WBPaper00005421 | |||
WBPaper00005654 | |||||||
WBPaper00006186 | |||||||
WBPaper00040287 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 21 Oct 2011 00:00:00 | ||||||
Automated_description | Enables sodium:proton antiporter activity. Involved in several processes, including determination of adult lifespan; positive regulation of growth rate; and regulation of transport. Located in apical plasma membrane. Expressed in intestine. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive spinocerebellar ataxia 19; congenital secretory sodium diarrhea 8; and end stage renal disease. Is an ortholog of human SLC9A3 (solute carrier family 9 member A3) and SLC9A5 (solute carrier family 9 member A5). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:783 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11078) | ||
DOID:0080065 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11071) | ||||
DOID:6000 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11071) | ||||
DOID:0060777 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11073) | ||||
Molecular_info | Corresponding_CDS | B0495.4 | |||||
Corresponding_CDS_history | B0495.4:wp239 | ||||||
Corresponding_transcript | B0495.4.1 | ||||||
Other_sequence (11) | |||||||
Associated_feature | WBsf988538 | ||||||
WBsf988539 | |||||||
WBsf1012587 | |||||||
WBsf223370 | |||||||
Experimental_info | RNAi_result (40) | ||||||
Expr_pattern | Expr113 | ||||||
Expr2233 | |||||||
Expr2241 | |||||||
Expr8046 | |||||||
Expr1020516 | |||||||
Expr1031742 | |||||||
Expr1143268 | |||||||
Expr2014254 | |||||||
Expr2032494 | |||||||
Drives_construct (47) | |||||||
Construct_product | WBCnstr00009193 | ||||||
WBCnstr00010721 | |||||||
WBCnstr00019888 | |||||||
WBCnstr00035911 | |||||||
Antibody | WBAntibody00002657 | ||||||
Microarray_results (18) | |||||||
Expression_cluster (213) | |||||||
Interaction (36) | |||||||
Map_info | Map | II | Position | 0.523763 | Error | 0.005206 | |
Positive | Positive_clone | B0495 | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Mapping_data | Multi_point | 4530 | |||||
5562 | |||||||
Pseudo_map_position | |||||||
Reference (26) | |||||||
Remark | Sequence connection from [Nehrke K, Melvin J] | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
nxh-2 nxh-3 nxh-4 nxh-5 nxh-6 nxh-7 nxh-8 nxh-9 published in cgc5421 actually refer to nhx genes | CGC_data_submission | ||||||
Method | Gene |