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WormBase Tree Display for Gene: WBGene00003730

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Name Class

WBGene00003730SMapS_parentSequenceB0495
IdentityVersion1
NameCGC_namenhx-2
Sequence_nameB0495.4
Molecular_nameB0495.4
B0495.4.1
CE48832
Other_nameCELE_B0495.4Accession_evidenceNDBBX284602
Public_namenhx-2
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:32WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classnhx
Allele (34)
StrainWBStrain00035710
RNASeq_FPKM (74)
GO_annotation (35)
Ortholog (49)
ParalogWBGene00003729Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00003736Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00003733Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00003735Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00003731Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00003943Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00003734Caenorhabditis elegansFrom_analysisTreeFam
Inparanoid_8
Panther
WormBase-Compara
WBGene00003732Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
Structured_descriptionConcise_descriptionnhx-2 encodes a sodium/proton exchanger; NHX-2 promotes normal peptide transporter function and recovery from intracellular acid load via catalysis of the electroneutral exchange of extracellular sodium for an intracellular proton; NHX-2 activity is required for normally high growth rates, and for propagation or maintenance of the germline; NHX-2 is expressed in the apical membranes of intestinal cells.Paper_evidenceWBPaper00005421
WBPaper00005654
WBPaper00006186
WBPaper00040287
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated21 Oct 2011 00:00:00
Automated_descriptionEnables sodium:proton antiporter activity. Involved in several processes, including determination of adult lifespan; positive regulation of growth rate; and regulation of transport. Located in apical plasma membrane. Expressed in intestine. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive spinocerebellar ataxia 19; congenital secretory sodium diarrhea 8; and end stage renal disease. Is an ortholog of human SLC9A3 (solute carrier family 9 member A3) and SLC9A5 (solute carrier family 9 member A5).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:783Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11078)
DOID:0080065Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11071)
DOID:6000Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11071)
DOID:0060777Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11073)
Molecular_infoCorresponding_CDSB0495.4
Corresponding_CDS_historyB0495.4:wp239
Corresponding_transcriptB0495.4.1
Other_sequence (11)
Associated_feature (4)
Experimental_infoRNAi_result (40)
Expr_patternExpr113
Expr2233
Expr2241
Expr8046
Expr1020516
Expr1031742
Expr1143268
Expr2014254
Expr2032494
Drives_constructWBCnstr00005316
WBCnstr00006696
WBCnstr00006697
WBCnstr00006858
WBCnstr00006859
WBCnstr00007701
WBCnstr00007702
WBCnstr00007703
WBCnstr00007704
WBCnstr00009190
WBCnstr00009193
WBCnstr00010712
WBCnstr00010721
WBCnstr00013075
WBCnstr00014893
WBCnstr00015512
WBCnstr00015809
WBCnstr00016647
WBCnstr00016648
WBCnstr00016649
WBCnstr00016650
WBCnstr00016651
WBCnstr00016652
WBCnstr00016653
WBCnstr00016654
WBCnstr00016656
WBCnstr00016657
WBCnstr00018463
WBCnstr00018464
WBCnstr00018937
WBCnstr00019325
WBCnstr00019326
WBCnstr00019888
WBCnstr00021202
WBCnstr00021203
WBCnstr00021204
WBCnstr00021205
WBCnstr00021206
WBCnstr00021207
WBCnstr00021208
WBCnstr00021209
WBCnstr00021210
WBCnstr00021687
WBCnstr00022447
WBCnstr00035911
WBCnstr00042191
WBCnstr00042711
Construct_productWBCnstr00009193
WBCnstr00010721
WBCnstr00019888
WBCnstr00035911
AntibodyWBAntibody00002657
Microarray_results (18)
Expression_cluster (213)
Interaction (36)
Map_infoMapIIPosition0.523763Error0.005206
PositivePositive_cloneB0495Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point4530
5562
Pseudo_map_position
Reference (26)
RemarkSequence connection from [Nehrke K, Melvin J]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
nxh-2 nxh-3 nxh-4 nxh-5 nxh-6 nxh-7 nxh-8 nxh-9 published in cgc5421 actually refer to nhx genesCGC_data_submission
MethodGene