nhx-2 encodes a sodium/proton exchanger; NHX-2 promotes normal peptide transporter function and recovery from intracellular acid load via catalysis of the electroneutral exchange of extracellular sodium for an intracellular proton; NHX-2 activity is required for normally high growth rates, and for propagation or maintenance of the germline; NHX-2 is expressed in the apical membranes of intestinal cells.
Enables sodium:proton antiporter activity. Involved in several processes, including determination of adult lifespan; positive regulation of growth rate; and regulation of transport. Located in apical plasma membrane. Expressed in intestine. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive spinocerebellar ataxia 19; congenital secretory sodium diarrhea 8; and end stage renal disease. Is an ortholog of human SLC9A3 (solute carrier family 9 member A3) and SLC9A5 (solute carrier family 9 member A5).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.
CGC_data_submission
nxh-2 nxh-3 nxh-4 nxh-5 nxh-6 nxh-7 nxh-8 nxh-9 published in cgc5421 actually refer to nhx genes