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WormBase Tree Display for Gene: WBGene00003730

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Name Class

WBGene00003730SMapS_parentSequenceB0495
IdentityVersion1
NameCGC_namenhx-2
Sequence_nameB0495.4
Molecular_nameB0495.4
B0495.4.1
CE48832
Other_nameCELE_B0495.4Accession_evidenceNDBBX284602
Public_namenhx-2
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:32WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classnhx
Allele (34)
StrainWBStrain00035710
RNASeq_FPKM (74)
GO_annotation (35)
Ortholog (49)
ParalogWBGene00003729Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00003736Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00003733Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00003735Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00003731Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00003943Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00003734Caenorhabditis elegansFrom_analysisTreeFam
Inparanoid_8
Panther
WormBase-Compara
WBGene00003732Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
Structured_descriptionConcise_descriptionnhx-2 encodes a sodium/proton exchanger; NHX-2 promotes normal peptide transporter function and recovery from intracellular acid load via catalysis of the electroneutral exchange of extracellular sodium for an intracellular proton; NHX-2 activity is required for normally high growth rates, and for propagation or maintenance of the germline; NHX-2 is expressed in the apical membranes of intestinal cells.Paper_evidenceWBPaper00005421
WBPaper00005654
WBPaper00006186
WBPaper00040287
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated21 Oct 2011 00:00:00
Automated_descriptionEnables sodium:proton antiporter activity. Involved in several processes, including determination of adult lifespan; positive regulation of growth rate; and regulation of transport. Located in apical plasma membrane. Expressed in intestine. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive spinocerebellar ataxia 19; congenital secretory sodium diarrhea 8; and end stage renal disease. Is an ortholog of human SLC9A3 (solute carrier family 9 member A3) and SLC9A5 (solute carrier family 9 member A5).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:783Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11078)
DOID:0080065Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11071)
DOID:6000Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11071)
DOID:0060777Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11073)
Molecular_infoCorresponding_CDSB0495.4
Corresponding_CDS_historyB0495.4:wp239
Corresponding_transcriptB0495.4.1
Other_sequence (11)
Associated_featureWBsf988538
WBsf988539
WBsf1012587
WBsf223370
Experimental_infoRNAi_result (40)
Expr_patternExpr113
Expr2233
Expr2241
Expr8046
Expr1020516
Expr1031742
Expr1143268
Expr2014254
Expr2032494
Drives_construct (47)
Construct_productWBCnstr00009193
WBCnstr00010721
WBCnstr00019888
WBCnstr00035911
AntibodyWBAntibody00002657
Microarray_resultsSMD_B0495.4
190293_at
A_12_P115566
Aff_B0495.4
GPL13394_WBGene00003730
GPL13914_B0495.4
GPL14144_B0495.4_1092-1151_0.887_17_A
GPL14144_B0495.4_928-987_0.883_20_B
GPL14144_B0495.4_982-1041_0.874_22_C
GPL19516_CGZ0001252
GPL21109_B0495.4
GPL3518_CE29549
GPL8304_CE_WBGene00003730_A
GPL8673_B0495_4P00393
GPL8673_B0495_4P00895
GPL8673_B0495_4P01719
GPL9450_B0495.4
cea2.c.09058
Expression_cluster (213)
InteractionWBInteraction000134080
WBInteraction000219066
WBInteraction000231307
WBInteraction000236879
WBInteraction000237224
WBInteraction000239100
WBInteraction000240842
WBInteraction000251903
WBInteraction000270433
WBInteraction000275904
WBInteraction000287813
WBInteraction000297773
WBInteraction000305349
WBInteraction000305626
WBInteraction000312669
WBInteraction000314432
WBInteraction000315138
WBInteraction000319975
WBInteraction000322314
WBInteraction000328384
WBInteraction000328385
WBInteraction000338920
WBInteraction000347112
WBInteraction000355480
WBInteraction000387576
WBInteraction000405829
WBInteraction000416055
WBInteraction000416921
WBInteraction000425106
WBInteraction000437433
WBInteraction000461226
WBInteraction000519729
WBInteraction000536617
WBInteraction000536692
WBInteraction000551602
WBInteraction000580200
Map_infoMapIIPosition0.523763Error0.005206
PositivePositive_cloneB0495Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point4530
5562
Pseudo_map_position
Reference (26)
RemarkSequence connection from [Nehrke K, Melvin J]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
nxh-2 nxh-3 nxh-4 nxh-5 nxh-6 nxh-7 nxh-8 nxh-9 published in cgc5421 actually refer to nhx genesCGC_data_submission
MethodGene