WormBase Tree Display for Gene: WBGene00003729

WBGene00003729 SMap: S_parent: Sequence: CHROMOSOME_X
  Identity: Version: 1
    Name: CGC_name: nhx-1
      Sequence_name: B0395.1
      Molecular_name: B0395.1
        B0395.1.1
        CE43178
        B0395.1.2
      Other_name: CELE_B0395.1 Accession_evidence: NDB BX284606
      Public_name: nhx-1
    DB_info: Database: AceView gene XQ635
        WormQTL gene WBGene00003729
        WormFlux gene WBGene00003729
        NDB locus_tag CELE_B0395.1
        Panther gene CAEEL|WormBase=WBGene00003729|UniProtKB=G5EDH8
          family PTHR10110
        NCBI gene 181680
        RefSeq protein NM_078221.8
        TREEFAM TREEFAM_ID TF317212
        TrEMBL UniProtAcc G5EDH8
        UniProt_GCRP UniProtAcc G5EDH8
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:32 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: nhx
    Allele (72)
    RNASeq_FPKM (74)
    GO_annotation (18)
    Ortholog (47)
    Paralog: WBGene00003736 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003733 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003735 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003731 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00003943 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00003730 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00003734 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00003732 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: nhx-1 encodes a sodium/proton exchanger expressed intracellularly within hypodermal and muscle cells; NHX-1 is required for embryonic viability, and is thought to prevent intracellular acidification by catalysing the electroneutral exchange of vesicular sodium for an intracellular proton. Paper_evidence: WBPaper00004651
            WBPaper00005421
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport; regulation of intracellular pH; and sodium ion import across plasma membrane. Predicted to be located in plasma membrane. Expressed in AIYL; AIYR; hypodermis; intestine; and muscle cell. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: B0395.1
    Corresponding_CDS_history: B0395.1:wp80
      B0395.1:wp196
    Corresponding_transcript: B0395.1.1
      B0395.1.2
    Other_sequence (17)
    Associated_feature: WBsf648838
      WBsf648839
      WBsf663673
      WBsf236825
  Experimental_info: RNAi_result: WBRNAi00039018 Inferred_automatically: RNAi_primary
      WBRNAi00024396 Inferred_automatically: RNAi_primary
      WBRNAi00024397 Inferred_automatically: RNAi_primary
      WBRNAi00027146 Inferred_automatically: RNAi_primary
      WBRNAi00009746 Inferred_automatically: RNAi_primary
      WBRNAi00001533 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr2232
      Expr2240
      Expr10075
      Expr1015368
      Expr1031741
      Expr1143180
      Expr2014253
      Expr2032493
    Drives_construct: WBCnstr00010711
      WBCnstr00010720
      WBCnstr00015047
      WBCnstr00035912
    Construct_product: WBCnstr00010720
      WBCnstr00035912
    Microarray_results (19)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:Harposporium_24hr_upregulated_RNAseq
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00042561:smgl-1(RNAi)_upregulated
      WBPaper00044037:eat-2_regulated_nhr-62_dependent
      WBPaper00044037:eat-2_upregulated
      WBPaper00044736:oscillating_dev_expression
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h
      WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00048611:MnCl2_downregulated
      WBPaper00048923:Aging_regulated
      WBPaper00049018:ham-3(RNAi)_upregulated
      WBPaper00049498:npr-1(ur89)_regulated_3
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00051021:4-bromodiphenyl-ether_downregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053388:dauer_regulated_Cluster4
      WBPaper00055013:spt-16(RNAi)_upregulated
      WBPaper00055226:ADR-2_target_adr-1(tm668)
      WBPaper00055226:ADR-2_target_N2
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055386:daf-2(e1370)_upregulated
      WBPaper00055482:Tunicamycin_downregulated
      WBPaper00055827:daf-2(e1370)_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056034:pals-25(jy9)_downregulated
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056284:ints-5(RNAi)_upregulated
      WBPaper00056290:hsp-6(mg585)_downregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00057068:ints-4(RNAi)_upregulated
      WBPaper00057068:ints-4(RNAi)_upregulated_Cadmium
      WBPaper00057265:metaformin_downregulated_OP50-MR
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058691:set-2(bn129)_upregulated
      WBPaper00058711:wdr-5(ok1417)_upregulated
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00058948:PA14_upregulated
      WBPaper00058969:RIS_depleted
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:G2_and_W_blasts
      WBPaper00061340:hyp7_AB_lineage
      WBPaper00061340:hyp7_C_lineage
      WBPaper00061340:P_cell
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061527:nhr-107_19485-nhr-109_3743
      WBPaper00061613:human-amyloid-beta_alpha-Synuclein(A53T)_downregulated
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062184:PA14_downregulated
      WBPaper00062193:daf-16(RNAi)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062345:bortezomib_4h_downregulated_N2
      WBPaper00062345:bortezomib_4h_downregulated_zip-1(jy13)
      WBPaper00062446:nhr-8(hd117)_downregulated
      WBPaper00062590:Aging_downregulated_hypodermis
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064539:nhr-114(gk849)_upregulated
      WBPaper00064769:him-17(me24)_upregulated
      WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
      WBPaper00065096:npr-8(ok1439)_upregulated_Day1_25C
      WBPaper00065926:pgph-2(overepxreesion)_upregulated_glucose
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      cgc4489_group_3
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00036286:Pattern_D
      WBPaper00038172:crh-1null_up_regulated
      WBPaper00038172:tax-6null_up_regulated
      WBPaper00038462:aging_downregulated
      WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00044535:male_downregulated
      WBPaper00047070:N2_UV_upregulated
      WBPaper00047070:xpa-1_UV_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00048989:N2_allantoin_upregulated
      WBPaper00048989:N2_rapamycin_upregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
    Interaction: WBInteraction000134079
      WBInteraction000362601
      WBInteraction000410939
  Map_info: Map: X Position: 23.335 Error: 0.165455
    Positive: Positive_clone: B0395 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00005421
    WBPaper00018859
    WBPaper00038491
    WBPaper00055090
  Remark: Sequence connection from [Nehrke K, Melvin J]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene