WormBase Tree Display for Gene: WBGene00003003

WBGene00003003 SMap: S_parent: Sequence: T25C12
  Identity: Version: 1
    Name: CGC_name: lin-14 Person_evidence: WBPerson261
      Sequence_name: T25C12.1
      Molecular_name: T25C12.1a
        T25C12.1a.1
        CE43285
        T25C12.1b
        CE03734
        T25C12.1b.1
      Other_name: CELE_T25C12.1 Accession_evidence: NDB BX284606
      Public_name: lin-14
    DB_info: Database: AceView gene XM103
        WormQTL gene WBGene00003003
        WormFlux gene WBGene00003003
        NDB locus_tag CELE_T25C12.1
        NCBI gene 181337
        RefSeq protein NM_077515.5
            NM_077516.7
        SwissProt UniProtAcc Q21446
        TREEFAM TREEFAM_ID TF316913
        UniProt_GCRP UniProtAcc Q21446
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:30 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: lin
    Reference_allele: WBVar00089301
      WBVar00089587
    Allele: WBVar00089450 Inferred_automatically: From strain object: MT1848
          From strain object: MT862
      WBVar00089496 Inferred_automatically: From strain object: MT925
      WBVar00088773 Inferred_automatically: From strain object: VT284
      WBVar00089447
      WBVar00089448
      WBVar00089592
      WBVar00089446
      WBVar00089449
      WBVar00275046
      WBVar00089709
      WBVar00275050
      WBVar00089589
      WBVar00089801
      WBVar00143283
      WBVar00089584
      WBVar00089799
      WBVar00089586
      WBVar00275051
      WBVar00089802
      WBVar00089588
      WBVar00089590
      WBVar00089797
      WBVar00275047
      WBVar00275043
      WBVar02153550
      WBVar02157624
      WBVar02157626
      WBVar02157627
      WBVar02157628
      WBVar01188254
      WBVar00300565
      WBVar01188255
      WBVar01188256
      WBVar02112319
      WBVar02027426
      WBVar01499887
      WBVar01188257
      WBVar02027427
      WBVar01188258
      WBVar01499888
      WBVar01602195
      WBVar01188259
      WBVar01602196
      WBVar01188260
      WBVar01602197
      WBVar01188261
      WBVar01188262
      WBVar01188263
      WBVar01499710
      WBVar01188264
      WBVar01897932
      WBVar01188265
      WBVar01897933
      WBVar01188266
      WBVar02032861
      WBVar01188267
      WBVar00274531
      WBVar01188268
      WBVar00274533
      WBVar00260216
      WBVar00089301
      WBVar01987711
      WBVar01987712
      WBVar02072669
      WBVar01987713
      WBVar02068023
      WBVar01987714
      WBVar01489247
      WBVar00601538
      WBVar01188114
      WBVar01188115
      WBVar01188116
      WBVar01188117
      WBVar01188118
      WBVar00089445
      WBVar01188119
      WBVar01188120
      WBVar01188121
      WBVar01188123
      WBVar01188124
      WBVar01188125
      WBVar01188126
      WBVar01188127
      WBVar01188128
      WBVar01188129
      WBVar01188130
      WBVar01188131
      WBVar01188132
      WBVar01188133
      WBVar01188134
      WBVar01188135
      WBVar01188136
      WBVar01188137
      WBVar01188138
      WBVar02152597
      WBVar01188139
      WBVar01188140
      WBVar01188141
      WBVar02009144
      WBVar01188142
      WBVar02009145
      WBVar01188143
      WBVar02009146
      WBVar01188144
      WBVar01188145
      WBVar01188146
      WBVar02093439
      WBVar01188147
      WBVar01188148
      WBVar01188149
      WBVar01188150
      WBVar01188151
      WBVar01188152
      WBVar01188153
      WBVar01188154
      WBVar01498128
      WBVar01188155
      WBVar01188156
      WBVar01188157
      WBVar00089582
      WBVar01188158
      WBVar00089583
      WBVar01188159
      WBVar00089585
      WBVar00089587
      WBVar01188160
      WBVar01497582
      WBVar01188161
      WBVar00089591
      WBVar01188162
      WBVar00089593
      WBVar00083186
      WBVar00089594
      WBVar01188163
      WBVar00083187
      WBVar01703416
      WBVar01494274
      WBVar01188164
      WBVar01188165
      WBVar00083188
      WBVar01703417
      WBVar01820533
      WBVar01188166
      WBVar00083189
      WBVar01188167
      WBVar00083190
      WBVar01188168
      WBVar00083191
      WBVar01493175
      WBVar01188169
      WBVar00083192
      WBVar01188170
      WBVar00083193
      WBVar00083194
      WBVar01188171
      WBVar00083195
      WBVar01188172
      WBVar01188173
      WBVar01188174
      WBVar01188175
      WBVar01188176
      WBVar01188177
      WBVar01188178
      WBVar01690508
      WBVar01188179
      WBVar01690509
      WBVar01188180
      WBVar01188181
      WBVar01690510
      WBVar01188182
      WBVar01690511
      WBVar01690512
      WBVar01188183
      WBVar01690513
      WBVar01188185
      WBVar01620587
      WBVar01188186
      WBVar01620588
      WBVar01500001
      WBVar01620589
      WBVar01188187
      WBVar01620590
      WBVar01500002
      WBVar01188188
      WBVar01188189
      WBVar01188190
      WBVar01188191
      WBVar00089668
      WBVar01188192
      WBVar01188193
      WBVar01759469
      WBVar01759470
      WBVar01188194
      WBVar01188195
      WBVar01759471
      WBVar01188196
      WBVar01487681
      WBVar01759472
      WBVar02051082
      WBVar01188197
      WBVar00517475
      WBVar00517476
      WBVar01188198
      WBVar02051083
      WBVar00517477
      WBVar01188199
      WBVar01188200
      WBVar00517478
      WBVar00517479
      WBVar01188201
      WBVar01188202
      WBVar00517480
      WBVar00517481
      WBVar01188203
      WBVar01188204
      WBVar00517482
      WBVar00517483
      WBVar01188205
      WBVar00089710
      WBVar01188206
      WBVar00517484
      WBVar00517485
      WBVar01188207
      WBVar01188208
      WBVar00517486
      WBVar01825919
      WBVar01188209
      WBVar00517487
      WBVar00517488
      WBVar01188210
      WBVar01188211
      WBVar00517489
      WBVar01188212
      WBVar00517490
      WBVar00517491
      WBVar01188213
      WBVar01981336
      WBVar00517492
      WBVar01188214
      WBVar01981337
      WBVar00517493
      WBVar01188215
      WBVar00517494
      WBVar01981338
      WBVar01188216
      WBVar01981339
      WBVar01188217
      WBVar00517495
      WBVar01981340
      WBVar01188218
      WBVar00517496
      WBVar01188219
      WBVar01981341
      WBVar00517497
      WBVar00517498
      WBVar02140121
      WBVar01188220
      WBVar00517499
      WBVar02140122
      WBVar01188221
      WBVar01188222
      WBVar02140123
      WBVar00517500
      WBVar01188223
      WBVar00517501
      WBVar01188224
      WBVar01787034
      WBVar00517502
      WBVar01188225
      WBVar00517503
      WBVar00517504
      WBVar01188226
      WBVar00517505
      WBVar01471181
      WBVar01188227
      WBVar00517506
      WBVar01188228
      WBVar01471182
      WBVar01188229
      WBVar00517507
      WBVar01471183
      WBVar00517508
      WBVar01471184
      WBVar01493787
      WBVar01188230
      WBVar01471185
      WBVar01188231
      WBVar00517509
      WBVar01493788
      WBVar01471186
      WBVar00517510
      WBVar01188232
      WBVar01188233
      WBVar01471187
      WBVar00517511
      WBVar01188234
      WBVar01471188
      WBVar00517512
      WBVar01188235
      WBVar01471189
      WBVar00517513
      WBVar00089798
      WBVar00517514
      WBVar01188236
      WBVar01471190
      WBVar00089800
      WBVar00517515
      WBVar01471191
      WBVar01188237
      WBVar00517516
      WBVar01188238
      WBVar00517517
      WBVar01188239
      WBVar01188240
      WBVar00517518
      WBVar00517519
      WBVar01188241
      WBVar01188242
      WBVar00517520
      WBVar01188243
      WBVar00517521
      WBVar00517522
      WBVar01188244
      WBVar00517523
      WBVar01188245
      WBVar00517524
      WBVar01188246
      WBVar01188247
      WBVar01188248
      WBVar01188249
      WBVar01188250
      WBVar01498960
      WBVar01188251
      WBVar01188252
      WBVar01494914
      WBVar01500067
      WBVar01188253
    Legacy_information: Class 1 alleles (loss-of-function) n526n540ird : precocious heterochronic lineage alterations in ectoderm; abnormal development of vulva endoderm and mesoderm; abnormal cuticle formation; ES2; male more severely affected only three molts gonadal development abnormal. Similar phenotype in n536n540/Df. NA > 10 (n179ts etc.; also Class 1a n355n679ird ts (only early events precocious); Class 1b n360ts (only late events precocious). Class 2 alleles (gain-of-function) n536sd : retarded heterochronic alterations in many lineages abnormal vulval development cuticle formation supernumerary molts extra divisions in sex mesoblasts intestine etc.; gonadal lineages normal. ES3. ME0? NA2 (n355sd). For both Class 1 and Class 2 mutations late lineages are less affected if animal develops via dauer stage.
      See also n179, n355, n360, n407, n530, n531, n532, n534, n535, n536, n539, n540, n679, n726, n727, n837, n838, n839, n840, n841, n842
      [C.elegansII] n526n540ird : lf allele (Class II, a-b-), precocious heterochronic lineage alterations in ectoderm; abnormal development of vulva,endoderm and mesoderm; abnormal cuticle formation; precocious dauer entry at L1 molt; ES2; male more severely affected, only three molts, gonadal development abnormal. Similar phenotype in n536n540/Df. OA>10: n179ts, etc.; also n355n679ird,ts (Class V, a-b+, only early events precocious); n360ts(Class III, a+b-, only late events precocious). Also gain-of-function alleles: n536sd (Class I, retarded heterochronic alterations in many lineages; abnormal vulval development, cuticle formation, supernumerary molts, extra divisions in sex mesoblasts, intestine etc.; gonadal lineages normal. ES3), n355sd(similar). Numerous intragenic revertants. For both lf and gf mutations, late lineages are less affected if animal develops via dauer stage. Cloned: two 3.5 kb transcripts, differing 5',encoding 70 kD novel proteins; antibodies stain nuclei; protein levels high in L1, reduced or absent later. Gain-of-function mutations affect3' UTR. [Ruvkun and Giusto 1989; Wightman et al. 1993; GR; VT]
    Strain (20)
    RNASeq_FPKM (74)
    GO_annotation (16)
    Ortholog (28)
    Structured_description: Concise_description: lin-14 encodes a novel protein whose activity is required for specifying the division timings of a specific group of cells during postembryonic development; lin-14 loss-of-function mutations result in the premature appearance of later larval lineages, while gain-of-function mutations result in reiteration of L1 larval stages lineages; in addition, lin-14 acts as a positive regulator of AVM, PVM, and FLP touch cell development; in regulating developmental timing, lin-14 acts, in part, by positively regulating the activity of lin-28, which encodes a cytoplasmic protein also required for proper developmental timing; at hatching, LIN-14 is detected in the nuclei of blast cells and neurons; later, from the late L1 to adult stages, LIN-14 levels are negatively regulated by translational repression mediated by lin-4, a 22-nt small temporal RNA (stRNA) that is complementary to sequences in the lin-14 3' UTR. Paper_evidence: WBPaper00000620
            WBPaper00001137
            WBPaper00001468
            WBPaper00001829
            WBPaper00001848
            WBPaper00003931
            WBPaper00005159
          Curator_confirmed: WBPerson1843
          Date_last_updated: 02 Sep 2005 00:00:00
      Automated_description: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and single-stranded DNA binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; regulation of cell fate specification; and regulation of nematode larval development, heterochronic. Located in condensed nuclear chromosome. Expressed in several structures, including QL; QR; neurons; oocyte; and somatic nervous system. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: T25C12.1a
      T25C12.1b
    Corresponding_CDS_history: T25C12.1a:wp196
    Corresponding_transcript: T25C12.1a.1
      T25C12.1b.1
    Other_sequence (11)
    Associated_feature (55)
    Transcription_factor: WBTranscriptionFactor000395
  Experimental_info: RNAi_result (17)
    Expr_pattern (13)
    Drives_construct: WBCnstr00000926
      WBCnstr00007336
      WBCnstr00007627
      WBCnstr00015030
      WBCnstr00015050
      WBCnstr00015780
      WBCnstr00015781
      WBCnstr00036292
    Construct_product: WBCnstr00000967
      WBCnstr00007627
      WBCnstr00019563
      WBCnstr00019564
      WBCnstr00021119
      WBCnstr00021910
      WBCnstr00036292
    Regulate_expr_cluster: WBPaper00026952:class_A
      WBPaper00026952:class_B
      WBPaper00026952:class_C
      WBPaper00026952:class_D
      WBPaper00026952:class_E
      WBPaper00026952:class_F
      WBPaper00026952:class_G
      WBPaper00026952:class_H
    Antibody: WBAntibody00000046
      WBAntibody00000337
      WBAntibody00000338
      WBAntibody00001031
      WBAntibody00001569
      WBAntibody00001873
    Microarray_results (33)
    Expression_cluster (173)
    Interaction (256)
    WBProcess: WBbiopr:00000031
      WBbiopr:00000057
      WBbiopr:00000083
  Map_info: Map: X Position: 3.78431 Error: 0.060767
    Well_ordered
    Positive: Inside_rearr: nDf19
        yDp8
        yDp10
      Positive_clone: PPE4
        T25C12 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 251
        492
        636
        637
        688
        3648
        3652
      Multi_point (22)
      Pos_neg_data: 3918
        3920
        654
        668
        3155
        294
        1831
        8427
  Reference (365)
  Method: Gene