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WormBase Tree Display for Gene: WBGene00002978

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Name Class

WBGene00002978SMapS_parentSequenceY105E8B
IdentityVersion1
NameCGC_namelev-11Person_evidenceWBPerson368
Sequence_nameY105E8B.1
Molecular_name (58)
Other_nametmy-1
Y105E8B.cCurator_confirmedWBPerson1983
RemarkOld cosmid naming mapped via unique overlapping PCR_product on CDSs
CeTMPaper_evidenceWBPaper00005168
WBPaper00032338
CELE_Y105E8B.1Accession_evidenceNDBBX284601
Public_namelev-11
DB_infoDatabase (12)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:30WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classlev
Reference_alleleWBVar00275207
Allele (206)
Legacy_informationx12 : slightly long uncoordinated mild twitcher phenotype grows well in 1 mM levamisole; strong semi-dominant suppressor of unc-90(e1463). ES3 ME2. NA3 (x1 : twitcher e1724 : lethal).
See also e1724
[Williams BD] Pat (paralysed arrest at two-fold), severe paralysis; st577 and st566 have some pharyngeal pumping.
[C.elegansII] x12 : slightly long, uncoordinated, mild twitcher phenotype; grows well in 1 mM levamisole; strong semi-dominant suppressor of unc-90(e1463). ES3 ME2. OA6: x1 (twitcher), e1724 (lethal). Also Pat (paralysed arrest at two-fold) alleles: st536 (severe paralysis),st577, st566 (some pharyngeal pumping. Greatly reduced staining for tropomyosin, probably corresponds to structural gene tmy-1. [Lewis et al. 1980; Williams and Waterston 1994; HK; ZZ]lfeLet-23 FErtility effector/regulator.PS.
[C.elegansII] Probably corresponds to lev-11. Three transcripts encoding tropomyosin, probable body wall and non-muscle isoforms (284 aa,different C-termini) and pharyngeal isoform (256 aa, different promoter). [Kagawa et al. 1995; HK]
StrainWBStrain00002959
WBStrain00033515
WBStrain00033518
WBStrain00033524
WBStrain00040917
WBStrain00040918
WBStrain00004923
RNASeq_FPKM (74)
GO_annotation (20)
Ortholog (47)
Structured_descriptionConcise_descriptionlev-11 encodes tropomyosin, an actin-binding contractile structural protein orthologous to human TROPOMYOSIN 1 (TPM1; OMIM:191010), which when mutated leads to familial hypertrophic cardiomyopathy; LEV-11 is required for embryonic development, normal body morphology, and locomotion; expressed as multiple tissue-specific isoforms generated by alternative mRNA splicing and promoter use, LEV-11 is detected in several tissues including muscle, pharynx, intestine, and the germ line.Paper_evidenceWBPaper00002748
WBPaper00004944
Curator_confirmedWBPerson1843
WBPerson1823
WBPerson567
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionEnables actin filament binding activity. Involved in several processes, including actin filament organization; regulation of actin polymerization or depolymerization; and spicule insertion. Located in striated muscle thin filament. Expressed in several structures, including body wall musculature; germ line; intestine; non-striated muscle; and pharynx. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); muscle tissue disease (multiple); and thyroid gland papillary carcinoma. Is an ortholog of several human genes including TPM1 (tropomyosin 1); TPM2 (tropomyosin 2); and TPM3 (tropomyosin 3).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0111597Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12011)
DOID:0110926Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12012)
DOID:0110309Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12010)
DOID:0110457Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12010)
DOID:3969Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12012)
DOID:0110932Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12011)
DOID:0080326Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12010)
DOID:0080102Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12012)
DOID:2218Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12013)
Molecular_infoCorresponding_CDS (19)
Corresponding_CDS_historyY105E8B.1b:wp62
Y105E8B.1b:wp114
Y105E8B.1c:wp62
Corresponding_transcript (20)
Other_sequence (913)
Associated_feature (35)
Experimental_infoRNAi_result (31)
Expr_pattern (15)
Drives_construct (12)
Construct_productWBCnstr00010369
WBCnstr00012505
WBCnstr00016244
WBCnstr00041176
AntibodyWBAntibody00000099
WBAntibody00000422
WBAntibody00000423
WBAntibody00000472
Microarray_results (61)
Expression_clusterWBPaper00005943:L1-L2_specific
WBPaper00005943:L3_specific
WBPaper00024704:Soluble_protein
WBPaper00026640:Development_Group_O
WBPaper00026640:embryo-to-L1_upregulated
WBPaper00028451:Oogenic_protein
WBPaper00029359_1280
WBPaper00029359_1310
WBPaper00029359_1364
WBPaper00029359_1444
WBPaper00029359_1504
WBPaper00029359_1578
WBPaper00029359_1604
WBPaper00032031:DConiospora_downregulated_OligoArray_24h
WBPaper00032528:L3_enriched
WBPaper00033065:clk-1(qm30)_upregulated
WBPaper00033065:cyc-1(RNAi)_upregulated
WBPaper00035314:acetic-acid_RF3_downregulated
WBPaper00035963:S.aureus_8h_downregulated
WBPaper00037047:aging_accelerated_insoluble_protein
WBPaper00037047:insoluble_protein
WBPaper00037615:hypoxia_upregulated
WBPaper00037946:LIN-39_interacting
WBPaper00037950:bodywall-muscle_L1-larva_expressed
WBPaper00037950:bodywall-muscle_L2-larva_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00038061:aldicarb_downregulated
WBPaper00038118:aak-2(gt33)_upregulated
WBPaper00038118:stress_upregulated_N2
WBPaper00038289:oocyte_protein
WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
WBPaper00040134:nhr-49(RNAi)_regulated_protein
WBPaper00040420:ALM_PLM_enriched
WBPaper00042561:smg-2(RNAi)_upregulated
WBPaper00042561:smgl-1(RNAi)_upregulated
WBPaper00042561:smgl-2(RNAi)_upregulated
WBPaper00044128:daf-2(e1370)_upregulated
WBPaper00044128:DietaryRestriction_upregulated
WBPaper00044426:rotenone_24h_upregulated
WBPaper00044501:gld-1_let-7_regulated
WBPaper00044578:reduced-humidity_downregulated_microarray
WBPaper00044736:flat_dev_expression
WBPaper00044746:aging_downregulated_Day5
WBPaper00044746:aging_downregulated_Day10
WBPaper00044746:aging_downregulated_HeatShock
WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
WBPaper00045521:Gender_Neutral
WBPaper00045571:germline-ablation_upregulated
WBPaper00045974:NSM_enriched_DSN-treated_RNAseq
WBPaper00046121:mesoderm_unique
WBPaper00046446:slow-synthesized_YoungAdult
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
WBPaper00046497:B.thuringiensis_upregulated_protein
WBPaper00046741:Garlic-Extract_downregulated_protein
WBPaper00046795:starvation_upregulated
WBPaper00046858:elt-2(RNAi)_downregulated
WBPaper00048644:germline_enriched
WBPaper00048910:Apoptosis-induced_mRNA-interacting_protein
WBPaper00048910:mRNA-interacting_protein
WBPaper00048923:Aging_regulated
WBPaper00048988:daf-2(e1370)_daf-16(mu86)_upregulated_neuron
WBPaper00048988:neuron_expressed
WBPaper00049217:TCER-1_downregulated
WBPaper00049498:npr-1(ur89)_regulated_3
WBPaper00049545:jmjd-3.1(+)_downregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
WBPaper00049732:blmp-1(tm548)_vs_N2_downregulated
WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
WBPaper00049920:Glucose-Diet_upregulated_N2
WBPaper00049942:HeatShock_upregulated_hsf-1(+)
WBPaper00050053:muscle_enriched_Day4
WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_24-cell-embryo
WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050636:aging_regulated_insoluble_protein
WBPaper00050698:DEP-1_interacting
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:body-muscle_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00050990:pharynx_expressed
WBPaper00050990:seam_expressed
WBPaper00051039:germline_enriched
WBPaper00051245:body-wall-muscle_cytoplasm_expressed
WBPaper00051245:cytoplasm_specific
WBPaper00051245:epidermis_cytoplasm_expressed
WBPaper00051245:intestine_cytoplasm_expressed
WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
WBPaper00051265:F4_hrde-1(tm1200)_downregulated
WBPaper00051461:pig-1(gm344)_downregulated
WBPaper00051558:aging_regulated
WBPaper00051558:fog-2(q71)_regulated
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053295:lin-22(ot269)_downregulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053318:Aging_downregulated_mRNA_N2
WBPaper00053321:PGCs_depleted_NuGen
WBPaper00053388:dauer_regulated_Cluster4
WBPaper00053599:female_vs_male_downregulated
WBPaper00053615:SMO-1_target
WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
WBPaper00053810:nuo-6(qm200)_upregulated
WBPaper00053814:15C_downregulated_PY79
WBPaper00054189:aging_regulated_protein
WBPaper00054189:P.aeruginosa_regulated_protein
WBPaper00055060:flr-1(RNAi)_downregulated
WBPaper00055103:thoc-5(wy822)_downregulated
WBPaper00055354:Psora-Allantoin_downregulated
WBPaper00055354:Psora_downregulated
WBPaper00055354:Rapamycin-Metformin_downregulated
WBPaper00055354:Rapamycin-Rifampicin_downregulated
WBPaper00055354:Rifampicin-Allantoin_downregulated
WBPaper00055354:Rifampicin_downregulated
WBPaper00055648:male-vas-deferens_expressed
WBPaper00055827:pfd-6(gk493446)_downregulated
WBPaper00055897:heat-shock_upregulated
WBPaper00055971:nhl-2(ok818)_20C_downregulated
WBPaper00056034:pals-22(jy3)_upregulated
WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
WBPaper00056139:gut-microbiota_downregulated
WBPaper00056139:soil-microbiota_upregulated
WBPaper00056161:hermaphrodite_enriched_siRNA
WBPaper00056443:DietaryRestriction_downregulated
WBPaper00056471:S.aureus-4h_downregulated_N2
WBPaper00056900:ERH-2_interacting
WBPaper00056900:PID-3_interacting
WBPaper00056900:TOFU-6_interacting
WBPaper00056900:TOST-1_interacting
WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
WBPaper00056997:NMAD-1_interacting
WBPaper00057140:meg-3(tm4259)_meg-4(ax2026)_downregulated
WBPaper00057288:Cold_downregulated_protein
WBPaper00057288:iff-1(RNAi)_downregulated_transcript
WBPaper00058598:mex-1(or286)_upregulated
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058598:spn-4(tm291)_upregulated
WBPaper00058725:sftb-1(cer6)_downregulated
WBPaper00058958:100mGy-irradiation-72h_upregulated
WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
WBPaper00059328:mrps-5(RNAi)_upregulated_protein
WBPaper00059471:EGL-43_interacting
WBPaper00059566:wdr-23(mac32)_upregulated
WBPaper00059567:olrn-1(ums9)_regulated
WBPaper00059605:MUT-16_interacting
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00059754:C.neoformans_H99_upregulated
WBPaper00059763:neuron_expressed
WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
WBPaper00059895:wounding_upregulated
WBPaper00059987:Wounding_upregulated
WBPaper00060683:hlh-11(ko1)_upregulated
WBPaper00061040:FW1256_upregulated
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061285:wounding_24h_downregulated
WBPaper00061340:BWM_anterior
WBPaper00061340:BWM_far_posterior
WBPaper00061340:mu_int_mu_anal
WBPaper00061340:mu_sph
WBPaper00061341:28C_48h_downregulated
WBPaper00061377:MYRF-1_interacting
WBPaper00061377:MYRF-2_interacting
WBPaper00061377:PAN-1_interacting
WBPaper00061439:unc-30(ok613)_upregulated
WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
WBPaper00061466:nath-10(icb99)_downregulated
WBPaper00061466:nath-10(icb102)_upregulated
WBPaper00061479:mep-1(ne4629)_upregulated
WBPaper00061479:prg-1(tm872)_upregulated
WBPaper00061479:ubc-9(ne4833)_upregulated
WBPaper00061527:176662_at-Y53F4B.16
WBPaper00061527:hlh-30_18579-unc-43_21739
WBPaper00061527:mup-2-unc-87_284
WBPaper00061527:tnt-4-myo-1_2160
WBPaper00061651:Gonadal_sheath_cell_enriched
WBPaper00061651:hmc_enriched
WBPaper00061651:Spermatheca_enriched
WBPaper00061818:AFD_enriched_protein
WBPaper00061902:camt-1(ok515)_regulated_RMG
WBPaper00062002:Day4-adult_secretome
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062193:skn-1(RNAi)_upregulated
WBPaper00062325:etr-1(lq61)_downregulated
WBPaper00062325:etr-1(lq61)_upregulated
WBPaper00062325:muscle_enriched_coding-RNA
WBPaper00062354:H.zoospora_6h_regulated
WBPaper00062498:PPM-1.D_interacting
WBPaper00062554:MAGU-2_interacting
WBPaper00062590:Aging_downregulated_neuron
WBPaper00062590:Aging_upregulated_hypodermis
WBPaper00062669:extracellular-vesicle_protein
WBPaper00064055:trl-1(cas1078)_upregulated_starved
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064130:Beta-Amyloid_downregulated_protein
WBPaper00064201:SNA-1_interacting
WBPaper00064201:SNA-3_interacting
WBPaper00064502:spe-44(fx110)_downregulated
WBPaper00064532:pals-25(icb98)_downregulated
WBPaper00064565:dyf-1(mn335)_regulated_protein
WBPaper00064716:paraquat_downregulated
WBPaper00064727:daf-2(e1370)_upregulated
WBPaper00064933:E.coli-binding_secret_protein
WBPaper00064992:Capsaicin_downregulated
WBPaper00065096:Day10_vs_Day1_downregulated
WBPaper00065120:body-muscle-transcriptome
WBPaper00065149:lin-52(n771)_downregulated
WBPaper00065158:AFD_depleted
WBPaper00065373:Cisplatin_upregulated_WT
WBPaper00065373:sek-1(km4)_upregulated_Ref
WBPaper00065581:hpk-1(pk1393)_upregulated
WBPaper00065623:11
WBPaper00065623:16
WBPaper00065623:29
WBPaper00065623:79
WBPaper00065623:86
WBPaper00065835:Day5_vs_Day1_downregulated
WBPaper00065835:Day11_vs_Day1_downregulated
WBPaper00065841:4_1
WBPaper00065841:7_0
WBPaper00065841:7_2
WBPaper00065841:7_3
WBPaper00065841:38_1
WBPaper00065841:38_3
WBPaper00065841:43_0
WBPaper00065841:143_0
WBPaper00065975:P-body_vs_oocyte_depleted
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00065993:glp-1(e2141)_upregulated
WBPaper00066085:sin-3(syb2172)_upregulated
WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
WBPaper00031003:0hr_muscle_enriched
WBPaper00031003:24hr_muscle_enriched
WBPaper00031003:hlh_1_enriched
WBPaper00031003:total_muscle_enriched
WBPaper00031060:2-deoxy-D-glucose_upregulated
WBPaper00031532:Larva_Pan_Neuronal_Depleted
WBPaper00031832:slr-2_regulated
WBPaper00034661:AgNPs_downregulated
WBPaper00035560:ahr-1_upregulated
WBPaper00035873:dpy-9_regulated
WBPaper00035873:dpy-10_regulated
WBPaper00036123:Atrazine_regulated
WBPaper00036383:ash-2_Day8_regulated
WBPaper00037113:CPF_16C_down-regulated
WBPaper00037695:LD_3-day
WBPaper00037695:LD_DD_6-day
WBPaper00038427:lin-54_embryo_changed
WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up
WBPaper00040210:Chlorpyrifos_24C_regulated
WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
WBPaper00040821:Au-NP_regulated
WBPaper00040823:alg-1(gk214)_upregulated
WBPaper00040858:eQTL_age_regulated_developing
WBPaper00040858:eQTL_regulated_aging
WBPaper00040858:eQTL_regulated_developing
WBPaper00040858:eQTL_regulated_old
WBPaper00040858:eQTL_regulated_reproductive
WBPaper00040963:TA100_up
WBPaper00040963:TA200_up
WBPaper00040963:TA300_up
WBPaper00040985:AIN-2_asynchronous_muscle
WBPaper00041002:HF_3d_0.2mM_Up
WBPaper00041002:HF_3d_2.0mM_Up
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041906:I-3690_vs_OP50_3d
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_24h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
WBPaper00042128:gei-8(ok1671)_downregulated
WBPaper00042258:DA1877_upregulated_GravidAdult
WBPaper00042331:a-SWCNTs_downregulated
WBPaper00042574:rde-1(ne219)_OrsayVirus_upregulated
WBPaper00045263:nuo-6(qm200)_downregulated
WBPaper00045865:biofilm_upregulated_A
WBPaper00045960:L1-L4-lethargus_upregulated
WBPaper00045960:L4-lethargus_upregulated
WBPaper00046853:AOBr_M.aeruginosa-batch-culture_downregulated
WBPaper00047070:N2_starvation_upregulated
WBPaper00047070:N2_UV_upregulated
WBPaper00048989:eat-2(ad465)_downregulated_in-DMSO
WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
WBPaper00048989:N2_allantoin_downregulated
WBPaper00048989:N2_rapamycin_upregulated
WBPaper00050650:mBmkTX_downregulated
WBPaper00053236:Starvation_regulated_GR1307
WBPaper00055899:nitroguanidine_regulated
WBPaper00057098:SiO2-nanoparticles_downregulated
Interaction (175)
WBProcessWBbiopr:00000006
Map_infoMapIPosition25.8125Error0.018971
Well_ordered
PositivePositive_cloneY105E8BInferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_data2_point209
213
214
327
5106
6076
Multi_point (11)
Pos_neg_data (13)
Reference (90)
RemarkData extracted from Williams & Waterston 1994
The gene tmy-1 was merged into this gene by krb on advice of JAH 25/02/02
MethodGene