| WBGene00002090 | Evidence | Paper_evidence | WBPaper00003057 |
|---|
| | | WBPaper00004623 |
| SMap | S_parent | Sequence | ZK1251 |
| Identity | Version | 1 |
| | Name | CGC_name | ins-7 | Person_evidence | WBPerson339 |
| | | Sequence_name | ZK1251.2 |
| | | Molecular_name | ZK1251.2a |
| | | | ZK1251.2a.1 |
| | | | CE03849 |
| | | | ZK1251.2b |
| | | | CE47202 |
| | | | ZK1251.2b.1 |
| | | Other_name | CELE_ZK1251.2 | Accession_evidence | NDB | BX284604 |
| | | Public_name | ins-7 |
| | DB_info | Database | AceView | gene | 4K446 |
| | | | WormQTL | gene | WBGene00002090 |
| | | | WormFlux | gene | WBGene00002090 |
| | | | NDB | locus_tag | CELE_ZK1251.2 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00002090|UniProtKB=Q23430 |
| | | | | family | PTHR33893 |
| | | | NCBI | gene | 191688 |
| | | | RefSeq | protein | NM_001268489.3 |
| | | | | | NM_001268488.3 |
| | | | SwissProt | UniProtAcc | Q23430 |
| | | | TrEMBL | UniProtAcc | H9G2S9 |
| | | | UniProt_GCRP | UniProtAcc | Q23430 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | ins |
| | Allele (14) |
| | Legacy_information | [Ferguson K] ins for INSulin related. No mutants known. |
| | Strain | WBStrain00032086 |
| | | WBStrain00048368 |
| | | WBStrain00048365 |
| | | WBStrain00048374 |
| | | WBStrain00048360 |
| | RNASeq_FPKM (74) |
| | GO_annotation | 00023681 |
| | | 00023682 |
| | | 00023683 |
| | | 00023684 |
| | | 00078437 |
| | | 00110010 |
| | | 00110011 |
| | Ortholog | WBGene00053993 | Caenorhabditis remanei | From_analysis | OMA |
| | | WBGene00083908 | Caenorhabditis remanei | From_analysis | OMA |
| | | WBGene00140898 | Caenorhabditis brenneri | From_analysis | WormBase-Compara |
| | | WBGene00158728 | Caenorhabditis brenneri | From_analysis | WormBase-Compara |
| | | CSP40.g8612 | Caenorhabditis tribulationis | From_analysis | WormBase-Compara |
| | | Csp11.Scaffold629.g16423 | Caenorhabditis tropicalis | From_analysis | WormBase-Compara |
| | | Csp5_scaffold_00132.g5201 | Caenorhabditis sinica | From_analysis | WormBase-Compara |
| | | chrIV_pilon.g11377 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | Paralog (19) |
| | Structured_description | Concise_description | ins-7 encodes an insulin/IGF-1-like peptide; INS-7 is one of 40 insulin-like peptides in C. elegans; INS-7 likely functions as an agonist for the DAF-2 insulin/IGF-1 receptor, as loss of ins-7 activity via RNAi results in: 1) a significantly increased lifespan that is not further extended in long-lived daf-2 mutant animals, and 2) an increased frequency of dauer formation in animals containing an incompletely penetrant daf-2 mutation; an ins-7 promoter fusion is expressed in amphid sensory neurons, labial neurons, the nerve ring, and ventral cord and tail neurons; ins-7 expression is positively regulated by DAF-2-mediated insulin signaling, suggesting that a positive feedback loop involving INS-7 may amplify DAF-2 pathway activity. | Paper_evidence | WBPaper00004623 |
| | | | | | WBPaper00005976 |
| | | | | | WBPaper00029214 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 13 Dec 2010 00:00:00 |
| | | Automated_description | Predicted to enable hormone activity. Involved in olfactory learning. Predicted to be located in extracellular region and membrane. Expressed in several structures, including distal tip cell; egg-laying apparatus; head muscle; neurons; and somatic nervous system. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | ZK1251.2a |
| | | ZK1251.2b |
| | Corresponding_transcript | ZK1251.2a.1 |
| | | ZK1251.2b.1 |
| | Associated_feature | WBsf230601 |
| Experimental_info | RNAi_result (23) |
| | Expr_pattern | Expr869 |
| | | Expr7824 |
| | | Expr10634 |
| | | Expr10845 |
| | | Expr11930 |
| | | Expr1014616 |
| | | Expr1162617 |
| | | Expr2012778 |
| | | Expr2031017 |
| | Drives_construct | WBCnstr00012946 |
| | | WBCnstr00013458 |
| | | WBCnstr00017002 |
| | | WBCnstr00017780 |
| | | WBCnstr00019811 |
| | | WBCnstr00020764 |
| | | WBCnstr00036462 |
| | Construct_product | WBCnstr00016055 |
| | | WBCnstr00020764 |
| | | WBCnstr00036462 |
| | Microarray_results (18) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_upregulated |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00036291:ung-1_regulated |
| | | WBPaper00037682:sma-2_downregulated |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L1-larva_expressed |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:excretory-cell_larva_enriched |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:intestine_larva_enriched |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_larva_enriched |
| | | WBPaper00038168:lin-35_upregulated |
| | | WBPaper00038438:D.coniospora_12hr_upregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_downregulated_RNAseq |
| | | WBPaper00038438:Harposporium_24hr_upregulated_RNAseq |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00040285:H2S_12hr_upregulated |
| | | WBPaper00041075:hcf-1(-)_skn-1(+)_downregulated |
| | | WBPaper00042561:smg-2(RNAi)_upregulated |
| | | WBPaper00042561:smgl-1(RNAi)_upregulated |
| | | WBPaper00042561:smgl-2(RNAi)_upregulated |
| | | WBPaper00044005:DAF-16_downregulated |
| | | WBPaper00044037:eat-2_upregulated |
| | | WBPaper00044316:CH3HgCl_7.5uM_downregulated |
| | | WBPaper00044426:rotenone_5day_downregulated |
| | | WBPaper00044578:reduced-humidity_downregulated_microarray |
| | | WBPaper00044736:oscillating_dev_expression |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Spermatogenic |
| | | WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_upregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h |
| | | WBPaper00048657:plep-1(ttTi53821)_regulated |
| | | WBPaper00049334:CE_intestine_enriched |
| | | WBPaper00049368:daf-2(e1370)_downregulated |
| | | WBPaper00049635:dop-1(vs100)_upregulated |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_24-cell-embryo |
| | | WBPaper00050225:flp-6(RNAi)_upregulated |
| | | WBPaper00050234:lin-28(RNAi)_downregulated |
| | | WBPaper00050448:KGB-1-induced |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_25C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C |
| | | WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050801:DAF-12_dauer_regulome |
| | | WBPaper00050801:DAF-16_dauer_regulome |
| | | WBPaper00050801:DPY-21_dauer_regulome |
| | | WBPaper00050801:SET-4_dauer_regulome |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00051265:F1_hrde-1(tm1200)_upregulated |
| | | WBPaper00051265:F4_hrde-1(tm1200)_upregulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053020:sid-3(ok973)_upregulated |
| | | WBPaper00053020:sta-1(ok587)_upregulated |
| | | WBPaper00053140:DecreasingResponse_20nmAgCit |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(icb38)_downregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053318:Aging_upregulated_mRNA_N2 |
| | | WBPaper00053318:mir-71(n4115)_upregulated_mRNA |
| | | WBPaper00053388:dauer_regulated_Cluster5 |
| | | WBPaper00053599:female_vs_male_downregulated |
| | | WBPaper00053771:up_at_dpy-7(e88) |
| | | WBPaper00053810:clk-1(qm30)_upregulated |
| | | WBPaper00054758:alg-2(ok304)_downregulated |
| | | WBPaper00055013:hmg-3(bar24)_upregulated |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin_upregulated |
| | | WBPaper00055354:Rifampicin_downregulated |
| | | WBPaper00055827:daf-2(e1370)_downregulated |
| | | WBPaper00055941:atfs-1(et15)_downregulated |
| | | WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated |
| | | WBPaper00055971:nhl-2(ok818)_20C_downregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056034:pals-25(jy9)_upregulated |
| | | WBPaper00056073:NHR-86_interacting_promoter |
| | | WBPaper00056161:male_enriched_siRNA |
| | | WBPaper00056167:Cry5B_downregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:flcn-1(ok975)_upregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057068:Cadmium_upregulated |
| | | WBPaper00057158:mdt-15(tm2182)_dependent_15C_downregulated |
| | | WBPaper00057196:raga-1(ok386)_upregulated) |
| | | WBPaper00057265:metaformin_downregulated_OP50-MR |
| | | WBPaper00057347:nhr-14(tm1473)_upreglated |
| | | WBPaper00058665:graphene-oxide_upregulated_mRNA |
| | | WBPaper00058711:paraquat_downregulated |
| | | WBPaper00058711:wdr-5(ok1417)_downregulated |
| | | WBPaper00058886:anp-1(ok608)_downregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059567:olrn-1(ums9)_regulated |
| | | WBPaper00059735:glucose_downregulated_lpin-1(RNAi) |
| | | WBPaper00059739:hira-1(gk835598)_upregulated_adult |
| | | WBPaper00059739:hira-1(gk835598)_upregulated_L4 |
| | | WBPaper00059839:S.maltophilia_regulated |
| | | WBPaper00059895:wounding_upregulated |
| | | WBPaper00059987:Wounding_upregulated |
| | | WBPaper00060100:SiNP_upregulated_mRNA |
| | | WBPaper00060278:atp-2(RNAi)_upregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_N2 |
| | | WBPaper00060445:ikb-1(nr2027)_upregulated_L4 |
| | | WBPaper00060445:nfki-1(cer1)_ikb-1(nr2027)_upregulated_L4 |
| | | WBPaper00060445:nfki-1(cer1)_upregulated_L4 |
| | | WBPaper00060526:plp-1(ok2155)_upregulated |
| | | WBPaper00060703:nas-38(ok3407)_upregulated |
| | | WBPaper00060764:swsn-9(ok1354)_upregulated |
| | | WBPaper00060909:atfs-1(cmh15)_upregulated |
| | | WBPaper00060911:prx-5(RNAi)_upregulated_mRNA |
| | | WBPaper00061007:S.aquatilis_upregulated |
| | | WBPaper00061040:eat-2(ad1116)_upregulated |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061424:Diet_MYb131_upregulated |
| | | WBPaper00061466:nath-10(icb102)_upregulated |
| | | WBPaper00061527:W01F3.2_1554-Y106G6D.8 |
| | | WBPaper00061530:nhr-49(e2144)_upregulated |
| | | WBPaper00061636:atracurium_downregulated |
| | | WBPaper00061753:csr-1(tor159)_upregulated_25C |
| | | WBPaper00062118:neural-HSF-1_upregulated |
| | | WBPaper00062167:mbl-1(tm1563)_upregulated |
| | | WBPaper00062193:skn-1(RNAi)_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062354:H.zoospora_6h_regulated |
| | | WBPaper00062520:qui-1(db104)_upregulated |
| | | WBPaper00062590:Aging_upregulated_intestine |
| | | WBPaper00062684:pathogen_downregulated_CB4856 |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064156:lbp-3(overexpress)_upregulated |
| | | WBPaper00064156:lipl-4(overexpress)_upregulated |
| | | WBPaper00064532:pals-25(icb98)_upregulated |
| | | WBPaper00064532:pals-25(jy111)_upregulated |
| | | WBPaper00064661:lpd-3(ok2138)_upregulated |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064728:cpl-1(W32AY35A)_upregulated |
| | | WBPaper00064933:bcf-1(ylf1)_upregulated_transcript |
| | | WBPaper00065029:cadmium_upregulated |
| | | WBPaper00065043:dcap-1(tm3163)_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065288:mdt-15(tm2182)_upregulated |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065734:unc-25(e156)_upregulated |
| | | WBPaper00065749:endu-2(tm4977)_upregulated |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065835:Day5_vs_Day1_upregulated |
| | | WBPaper00065835:mtH2S-AP39-D0-treatment_downregulated_Day5 |
| | | WBPaper00065877:rege-1(imm070)_upregulated_OP50 |
| | | WBPaper00065877:rege-1(imm070)_upregulated_PA14 |
| | | WBPaper00065926:pgph-2(overepxreesion)_upregulated |
| | | WBPaper00065984:pals-17(syb3980)_upregulated |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066005:RAGA-1_degradation_somatic_upregulated |
| | | WBPaper00066110:Doxorubicin_upregulated_diploid |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14 |
| | | WBPaper00066204:CdCl2_upregulated_mRNA |
| | | WBPaper00066232:ash-2(RNAi)_downregulated_WT |
| | | WBPaper00066232:hsf-1(RNAi)_upregulated_ash-2 |
| | | cgc4489_group_11 |
| | | cgc4489_group_17 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00027111:rrf-3(pk1426)_upregulated |
| | | WBPaper00029437:dcr-1_upregulated |
| | | WBPaper00029437:rde-4_upregulated |
| | | WBPaper00032062:age_regulated_genes |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_4 |
| | | WBPaper00033101:spr-5_regulated |
| | | WBPaper00034757:up_by_oxidative_stress |
| | | WBPaper00035479:daf-16(RNAi)_upregulated |
| | | WBPaper00035873:osm-11_regulated |
| | | WBPaper00036130:mir-243_down_regulated |
| | | WBPaper00036286:Pattern_F |
| | | WBPaper00040184:hcf-1down_sir-2.1down_daf-2down |
| | | WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2 |
| | | WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.5 |
| | | WBPaper00040823:alg-1(gk214)_upregulated |
| | | WBPaper00041002:HQ_3d_2.0mM_Up |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041609:hpl-1_hpl-2_upregulated |
| | | WBPaper00042258:DA1877_upregulated_GravidAdult |
| | | WBPaper00042574:JU1580_OrsayVirus_upregulated |
| | | WBPaper00045015:nhr-25(RNAi)_upregulated |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00046548:dafachronic-acid_upregulated |
| | | WBPaper00047070:N2_UV_upregulated |
| | | WBPaper00047070:xpa-1_UV_upregulated |
| | | WBPaper00050767:Octopamine_induced |
| | | WBPaper00055435:AuNPs_upregulated |
| | | WBPaper00055435:MUA-AuNP-0.5_upregulated |
| | | WBPaper00055899:2,4-Dinitroanisole_regulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc5976]:class_2 |
| | | [cgc6390]:Cluster_D |
| | | [cgc6390]:mixed_spermatogenesis-somatic |
| | | [cgc6390]:spermatogenesis-enriched |
| | Interaction (153) |
| | WBProcess | WBbiopr:00000001 |
| | | WBbiopr:00000008 |
| | | WBbiopr:00000039 |
| Map_info | Map | IV | Position | 4.35256 | Error | 0.001133 |
| | Positive | Positive_clone | ZK1251 | Author_evidence | Ferguson KC |
| | | | | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 5260 |
| | | | 5454 |
| | Pseudo_map_position |
| Reference (61) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
