ida-1 encodes a protein tyrosine phosphatase-like receptor, orthologous to the mammalian type I diabetes autoantigens IA-2 and phogrin that are expressed in dense core vesicles of neuroendocrine tissue and involved in regulated protein secretion; in C. elegans, IDA-1 appears to be required for regulating presynaptic neurotransmission and in particular, for the neuropeptidergic control of egg-laying; ida-1 interacts genetically with unc-31 and unc-64, which encode proteins required for dense core vesicle fusion and exocytosis; ida-1 expression is detected in a subset of neurons in the anterior nerve ring, the ventral nerve cord, the tail, and the vulva, including the VC vulval motoneurons and the HSN egg-laying neurons; ida-1 is also detected in the vulval uv1 cells, non-neuronal cells that contain neurosecretory-like vesicles.
Predicted to enable transmembrane receptor protein tyrosine phosphatase activity. Involved in positive regulation of anterior/posterior axon guidance; positive regulation of neurotransmitter secretion; and ventral cord development. Located in dense core granule and synapse. Expressed in several structures, including buccal cavity; neurons; preanal ganglion; somatic nervous system; and uv1. Used to study Parkinson's disease and diabetes mellitus. Human ortholog(s) of this gene implicated in prediabetes syndrome and type 1 diabetes mellitus. Is an ortholog of human PTPRN2 (protein tyrosine phosphatase receptor type N2).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.