[Maine EM] Recessive suppressor of ts glp-1 alleles q224 and q231, suppresses both germ-line and embryonic defects. Does not suppress stronger glp-1 alleles. No phenotype alone. Other alleles exhibit complex non-allelic non-complementation with mutations of other sog genes.
[C.elegansII] q305 : recessive suppressor of ts glp-1 alleles q224 and q231, suppresses both germ-line and embryonic defects. Does not suppress stronger glp-1 alleles. No phenotype alone. Other alleles exhibit complex non-allelic non-complementation with mutations of other sog genes. OA1: q298 [Maine and Kimble 1993; EL]
Complementation_data
[Maine EM] Fails to complement 6 other sog-1 alleles, complements mutations of other sog genes.
F36A2.13 encodes an E3 ubiquitin ligase similar to the mammalian UBR5 ubiquitin ligases; F36A2.13 is predicted to function in ubiquitin-dependent protein catabolic processes.
Predicted to enable ubiquitin-ubiquitin ligase activity. Predicted to be involved in positive regulation of canonical Wnt signaling pathway and protein polyubiquitination. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in carcinoma (multiple) and invasive ductal carcinoma. Is an ortholog of human UBR5 (ubiquitin protein ligase E3 component n-recognin 5).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.