[C.elegansII] NMK. Encodes two protein kinase L isoforms, PKL1 (1528 aa, ST kinase, low in embryos, increases 5-fold on hatching) andPKL2 (1377 aa, different C-term, maximal in embryos, absent in L1). [CR]
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to be located in cytoplasm. Expressed in head neurons; intestine; and tail neurons. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 108; female breast cancer; and mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations. Is an ortholog of human MAST1 (microtubule associated serine/threonine kinase 1) and MAST3 (microtubule associated serine/threonine kinase 3).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.