dli-1 encodes a dynein light intermediate chain; dli-1 activity, presumably as part of a cytoplasmic dynein minus-end-directed motor complex, is required for mitoses throughout development, for pronuclear and nuclear migration, and for normal neuronal function; DLI-1 has been shown to physically interact with the ZYG-12 HOOK-domain containing protein and the UNC-16 JIP3 (c-Jun N-terminal kinase (JNK)-interacting protein 3) protein.
Predicted to enable dynein heavy chain binding activity. Involved in regulation of dendrite morphogenesis and retrograde axonal transport. Located in microtubule plus-end and neuron projection. Expressed in ciliated neurons; hypodermis; and pharynx. Is an ortholog of human DYNC1LI2 (dynein cytoplasmic 1 light intermediate chain 2).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.