WormBase Tree Display for Gene: WBGene00003997
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WBGene00003997 | SMap | S_parent | Sequence | CHROMOSOME_X | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | pgp | ||||||
Allele (77) | |||||||
Legacy_information | [C.elegansII] pk18 : deletion derived from pk30tci, increased sensitivity to colchicine and to chloroquine; gross phenotype WT. Cloned: encodes 1254 aa P-glycoprotein, 61-65% identical to mammalian P-glycoproteins. Transcripts present throughout development; pgp-1:lacZ expressed in intestine, throughout development. Tagged PGP-3 detected in apical membranes of gut and of excretory cell. [Broeks et al. 1995; NL] | ||||||
Strain | WBStrain00028887 | ||||||
WBStrain00028888 | |||||||
WBStrain00028891 | |||||||
WBStrain00033025 | |||||||
WBStrain00037266 | |||||||
WBStrain00004731 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (21) | |||||||
Ortholog (71) | |||||||
Paralog | WBGene00001811 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | |||||||
WBGene00001812 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00001813 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00001814 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00001815 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00001816 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00001817 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00001818 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00001819 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00003995 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00003998 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | ||||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00004003 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00004002 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00004001 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00003999 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00004000 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00004004 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00004006 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00004007 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00004008 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00004005 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00022281 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00003996 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
Structured_description | Concise_description | pgp-3 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; with PGP-1, PGP-3 is required for defense against the pathogenic Pseudomonas aeruginosa strain PA14, and may facilitate ATP-dependent efflux of the toxic phenazine compounds produced by the bacteria; PGP-3 is also required for resistance to colchicine and chloroquine; PGP-3 is expressed in the apical membranes of the excretory cell and the intestinal cells. | Paper_evidence | WBPaper00002180 | |||
WBPaper00003366 | |||||||
WBPaper00003925 | |||||||
WBPaper00004651 | |||||||
WBPaper00005654 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 03 Apr 2014 00:00:00 | ||||||
Automated_description | Predicted to enable ATPase-coupled transmembrane transporter activity and efflux transmembrane transporter activity. Involved in defense response to Gram-negative bacterium; innate immune response; and stress response to cadmium ion. Located in apical plasma membrane. Expressed in excretory canal; excretory cell; intestinal cell; intestine; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); and intrahepatic cholestasis (multiple). Is an ortholog of several human genes including ABCB1 (ATP binding cassette subfamily B member 1); ABCB11 (ATP binding cassette subfamily B member 11); and ABCB4 (ATP binding cassette subfamily B member 4). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model (41) | ||||||
Molecular_info | Corresponding_CDS | ZK455.7 | |||||
Corresponding_transcript | ZK455.7.1 | ||||||
Other_sequence (21) | |||||||
Associated_feature | WBsf1006975 | ||||||
Experimental_info | RNAi_result | WBRNAi00059437 | Inferred_automatically | RNAi_primary | |||
WBRNAi00022018 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00014821 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00001488 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern (13) | |||||||
Drives_construct | WBCnstr00002142 | ||||||
WBCnstr00010331 | |||||||
WBCnstr00011338 | |||||||
WBCnstr00011339 | |||||||
WBCnstr00012125 | |||||||
WBCnstr00012126 | |||||||
WBCnstr00012634 | |||||||
WBCnstr00015310 | |||||||
WBCnstr00035753 | |||||||
Construct_product | WBCnstr00012634 | ||||||
WBCnstr00014565 | |||||||
WBCnstr00014566 | |||||||
WBCnstr00035753 | |||||||
Antibody | WBAntibody00000095 | ||||||
Microarray_results (17) | |||||||
Expression_cluster (180) | |||||||
Interaction (34) | |||||||
Map_info | Map | X | Position | 3.16596 | Error | 0.03869 | |
Positive | Positive_clone | PB#CPG4 | |||||
ZK455 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Pseudo_map_position | |||||||
Reference (46) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |