WormBase Tree Display for Gene: WBGene00003222
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WBGene00003222 | Evidence | CGC_data_submission | |||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | Y2H9A | ||||
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | mes | ||||||
Allele (85) | |||||||
Legacy_information | [C.elegansII] bn50 : grandchildless, progeny undergo normal embryogenesis but develop into agametic adults(only 10 germ cells made). Normal P granule staining. XO germ line much less affected.OA3: bn23, bn58, bn67 (all similar). [Capowski et al. 1991; SS] | ||||||
Strain | WBStrain00022581 | ||||||
WBStrain00034440 | |||||||
WBStrain00036937 | |||||||
WBStrain00029957 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (30) | |||||||
Ortholog (56) | |||||||
Paralog | WBGene00003040 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | |||||||
WBGene00016603 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00003220 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00004781 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00004782 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00008062 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00008206 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00008527 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00011729 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00012802 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00018023 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00019584 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00019690 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00019883 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00020006 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00020919 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00020920 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00021282 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00021515 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
Structured_description | Concise_description | mes-4 encodes a SET domain-containing protein that also contains three plant homeodomain (PHD) fingers; MES-4 is required maternally for normal germline development, but in contrast to MES-2, -3, and -6, does not appear to be required for somatic anteroposterior patterning; in germline development, MES-4 activity is essential for regulating active chromatin states and for excluding the MES-2/MES-3/MES-6 chromatin repression complex from the autosomes; MES-4 is also required for germline silencing of repetitive transgene arrays; MES-4 localizes to autosomes, and is detectable in the distal, mitotic region of the germline, in meiotic germ cells during late pachytene, and in oocytes; MES-4 is detected in all somatic and germline nuclei of the early embryo, but by the 100-cell stage, its expression becomes restricted to the primordial germ cells, Z2 and Z3; exclusion of MES-4 from X chromosomes requires the activity of the MES-2, -3, -6 complex. | Paper_evidence | WBPaper00002979 | |||
WBPaper00005301 | |||||||
WBPaper00005923 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 30 Jul 2004 00:00:00 | ||||||
Automated_description | Enables histone H3K36 methyltransferase activity. Involved in germ-line sex determination and heterochromatin formation. Acts upstream of or within with a positive effect on dosage compensation by hypoactivation of X chromosome. Located in X chromosome; autosome; and nuclear chromosome. Part of chromatin. Expressed in Z2; Z3; and germ line. Human ortholog(s) of this gene implicated in several diseases, including Sotos syndrome 1; lung non-small cell carcinoma; and neuroblastoma. Is an ortholog of human NSD1 (nuclear receptor binding SET domain protein 1); NSD2 (nuclear receptor binding SET domain protein 2); and NSD3 (nuclear receptor binding SET domain protein 3). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:0112103 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14234) | ||
DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12766) | ||||
DOID:10907 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14234) | ||||
DOID:14748 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14234) | ||||
DOID:769 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14234) | ||||
DOID:8692 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12767) | ||||
DOID:9119 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14234) | ||||
Molecular_info | Corresponding_CDS | Y2H9A.1 | |||||
Corresponding_CDS_history | Y2H9A.1:wp51 | ||||||
Corresponding_transcript | Y2H9A.1.1 | ||||||
Other_sequence | AF233290 | ||||||
CBC09012_1 | |||||||
CBC03017_1 | |||||||
CRC01044_1 | |||||||
CR09817 | |||||||
CR07209 | |||||||
CRC02608_1 | |||||||
Associated_feature (11) | |||||||
Gene_product_binds (4418) | |||||||
Transcription_factor | WBTranscriptionFactor000137 | ||||||
Experimental_info | RNAi_result (41) | ||||||
Expr_pattern | Expr1905 | ||||||
Expr4222 | |||||||
Expr14367 | |||||||
Expr1027992 | |||||||
Expr1031522 | |||||||
Expr1159295 | |||||||
Expr1200052 | |||||||
Expr2013532 | |||||||
Expr2031766 | |||||||
Drives_construct | WBCnstr00036178 | ||||||
Construct_product | WBCnstr00036178 | ||||||
Regulate_expr_cluster | WBPaper00028483:Down_mes-4_vs_WT | ||||||
WBPaper00028483:Up_mes-4_vs_WT | |||||||
WBPaper00041688:mes-2_mes-4_downregulated | |||||||
WBPaper00041688:mes-2_mes-4_upregulated | |||||||
WBPaper00064315:mes-4(bn73)_downregulated_EGCs | |||||||
WBPaper00064315:mes-4(bn73)_downregulated_PGCs | |||||||
WBPaper00064315:mes-4(bn73)_upregulated_EGCs | |||||||
WBPaper00064315:mes-4(bn73)_upregulated_PGCs | |||||||
Antibody | WBAntibody00000524 | ||||||
WBAntibody00001161 | |||||||
WBAntibody00001162 | |||||||
WBAntibody00001462 | |||||||
Microarray_results (18) | |||||||
Expression_cluster (153) | |||||||
Interaction (83) | |||||||
Map_info | Map | V | Position | 5.34414 | Error | 0.004146 | |
Well_ordered | |||||||
Positive | Positive_clone | Y2H9A | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Y29H9A | |||||||
Mapping_data | 2_point | 6090 | |||||
6091 | |||||||
6092 | |||||||
6093 | |||||||
6094 | |||||||
6095 | |||||||
6096 | |||||||
6097 | |||||||
6098 | |||||||
Multi_point | 2157 | ||||||
2158 | |||||||
2159 | |||||||
2160 | |||||||
2161 | |||||||
2162 | |||||||
2163 | |||||||
2164 | |||||||
2165 | |||||||
2166 | |||||||
Pos_neg_data | 6685 | ||||||
6686 | |||||||
6687 | |||||||
Landmark_gene | |||||||
Reference (120) | |||||||
Remark | Sequence connection from [Strome S] | ||||||
Method | Gene |