WormBase Tree Display for Gene: WBGene00010988

WBGene00010988 SMap: S_parent: Sequence: R03D7
  Identity: Version: 2
    Name: CGC_name: metr-1 Person_evidence: WBPerson1711
      Sequence_name: R03D7.1
      Molecular_name: R03D7.1
        R03D7.1.1
        CE01609
      Other_name: CELE_R03D7.1 Accession_evidence: NDB BX284602
      Public_name: metr-1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:52 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 20 Apr 2011 10:05:24 WBPerson2970 Name_change: CGC_name: metr-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: metr
    Allele (55)
    Strain (3)
    RNASeq_FPKM (74)
    GO_annotation (23)
    Ortholog (39)
    Paralog: WBGene00015512 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00020491 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: metr-1 encodes a protein orthologous to the human gene Methionine synthase (MTR), which is involved in the conversion of homocysteine to form methionine. Paper_evidence: WBPaper00042203
          Curator_confirmed: WBPerson324
            WBPerson1823
            WBPerson567
          Date_last_updated: 07 May 2013 00:00:00
      Automated_description: Predicted to enable methionine synthase activity. Predicted to be involved in homocysteine metabolic process; methionine biosynthetic process; and tetrahydrofolate metabolic process. Predicted to be located in cytosol. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; autistic disorder; and hematologic cancer (multiple). Is an ortholog of human MTR (5-methyltetrahydrofolate-homocysteine methyltransferase). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:9352 Homo sapiens Paper_evidence: WBPaper00042203
          Curator_confirmed: WBPerson324
          Date_last_updated: 13 Mar 2023 00:00:00
    Potential_model (14)
  Models_disease_asserted: WBDOannot00000175
  Molecular_info: Corresponding_CDS: R03D7.1
    Corresponding_transcript: R03D7.1.1
    Other_sequence (51)
    Associated_feature: WBsf222084
      WBsf222085
  Experimental_info: RNAi_result: WBRNAi00071221 Inferred_automatically: RNAi_primary
      WBRNAi00034551 Inferred_automatically: RNAi_primary
      WBRNAi00090587 Inferred_automatically: RNAi_primary
      WBRNAi00051170 Inferred_automatically: RNAi_primary
      WBRNAi00106971 Inferred_automatically: RNAi_primary
      WBRNAi00017346 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram417
      Chronogram1093
      Expr6447
      Expr6448
      Expr1028258
      Expr1034818
      Expr1154877
      Expr2013538
      Expr2031772
    Drives_construct: WBCnstr00002636
      WBCnstr00004383
    Regulate_expr_cluster: WBPaper00060951:metr-1(os521)_downregulated
      WBPaper00060951:metr-1(os521)_upregulated
    Microarray_results (20)
    Expression_cluster: WBPaper00032528:L3_enriched
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_embryo_enriched
      WBPaper00037950:hypodermis_embryo_SelectivelyEnriched
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_embryo_enriched
      WBPaper00037950:intestine_embryo_SelectivelyEnriched
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038118:aak-2(gt33)_upregulated
      WBPaper00038168:lin-15B(n744)_downregulated
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00040412:germline-regulated_daf-16_target
      WBPaper00041071:spe-44_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045050:csr-1(hypomorph)_downregulated
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_downregulated
      WBPaper00045774:clk-1_downregulated
      WBPaper00046128:ethanol_upregulated
      WBPaper00046337:monosomal_N2_vs_daf-2_upregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00048910:mRNA-interacting_protein
      WBPaper00048988:neuron_expressed
      WBPaper00049290:rsks-1(sv31)_downregulated
      WBPaper00049498:npr-1(ur89)_regulated_6
      WBPaper00049905:Age_variant_expression
      WBPaper00049954:BPS_downregulated
      WBPaper00050015:ifg-1(RNAi)_upregulated
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051265:F4_hrde-1(tm1200)_downregulated
      WBPaper00051311:VGLN-1-interacting
      WBPaper00051352:Long-Term-Association-Memory_downregulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053094:adr-2(ok735)_neuron_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053289:DREAM-target
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
      WBPaper00053388:dauer_regulated_Cluster5
      WBPaper00053810:isp-1(qm150)_downregulated
      WBPaper00053810:nuo-6(qm200)_downregulated
      WBPaper00053814:OP50_vs_PY79_upregulated_PY79
      WBPaper00055013:HMG-3_interacting_protein
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055827:daf-2(e1370)_downregulated
      WBPaper00055827:pfd-6(gk493446)_downregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055941:atfs-1(et15)_downregulated
      WBPaper00055941:nuo-6(qm200)_downregulated
      WBPaper00055971:nhl-2(ok818)_20C_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056073:NHR-86_interacting_promoter
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_downregulated_N2
      WBPaper00056139:gut-microbiota_downregulated
      WBPaper00056167:ifo-1(kc2)_upregulated
      WBPaper00056275:P.aeruginosa_downregulated
      WBPaper00056293:rpl-5(0)-rpl-33(0)_downregulated
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00057041:spc-1(cas971)_upregulated
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058691:sin-3(tm1276)_upregulated
      WBPaper00058691:WDR-5.1_interacting_protein
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00058725:sftb-1(cer39)_downregulated
      WBPaper00058948:PA14_upregulated
      WBPaper00059254:CSR-1_interacting
      WBPaper00059254:PRG-1_interacting
      WBPaper00059824:rnp-6(dh1127)_regulated_OP50
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00059895:wounding_downregulated
      WBPaper00059987:Wounding_downregulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060014:set-2(zr2012)_upregulated
      WBPaper00060084:cco-1(RNAi)_downregulated_lin-40(yth27)
      WBPaper00060084:cco-1(RNAi)_downregulated_N2
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060445:nfki-1(cer1)_upregulated_L1
      WBPaper00060459:bcat-1(RNAi)_downregulated
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060871:M.humicola-extract_1h_regulated
      WBPaper00060951:metr-1(os521)_downregulated
      WBPaper00061081:E.faecalis_downregulated_skpo-1(ok1640)
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061479:HDA-1_interacting_protein
      WBPaper00061527:tars-1-AFFX-r2-3026-5_at
      WBPaper00061753:csr-1(tor159)_downregulated_20C
      WBPaper00062056:lin-15B(we23)_downregulated
      WBPaper00062056:lin-37(n758)_downregulated
      WBPaper00062078:NMR-HspB1_regulated
      WBPaper00062123:DEPS-1_interacting
      WBPaper00062123:GLH-1_interacting
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062554:MAGU-2_interacting
      WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA
      WBPaper00064005:starvation_downregulated_N2_mRNA
      WBPaper00064055:trl-1(cas1077)_upregulated_non-starved
      WBPaper00064055:trl-1(cas1077)_upregulated_starved
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064107:lin-35(n745)_downregulated
      WBPaper00064122:vulva_transcriptome
      WBPaper00064130:Beta-Amyloid_24h_upregulated_mRNA
      WBPaper00064130:Beta-Amyloid_upregulated_protein
      WBPaper00064156:lbp-3(overexpress)_upregulated
      WBPaper00064315:mes-4(bn73)_downregulated_EGCs
      WBPaper00064735:bet-1(uth41)_vs_N2_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065373:sek-1(km4)_downregulated_cisplatin
      WBPaper00065373:sek-1(km4)_downregulated_Ref
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065841:2_0
      WBPaper00065841:3_0
      WBPaper00065945:epidermis-rpoa-2(-)_downregulated_protein
      WBPaper00065945:global-rpoa-2(-)_downregulated_transcript
      WBPaper00065975:P-body_vs_oocyte_enriched
      WBPaper00065975:P-body_vs_WholeAnimal_enriched
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      cgc4386_cluster_2_4
      cgc4489_group_3
      WBPaper00024393:strongly_regulated_dauer_genes
      WBPaper00025032:cluster_27
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026952:class_A
      WBPaper00026980:intestine_enriched
      WBPaper00028474:dys-1_upregulated
      WBPaper00031060:2-deoxy-D-glucose_downregulated
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00031832:slr-2_regulated
      WBPaper00034739:N2lessDR1350
      WBPaper00035084:embryo_enriched_AIN-2_IP
      WBPaper00035084:L1_enriched_AIN-2_IP
      WBPaper00035084:L2_enriched_AIN-2_IP
      WBPaper00035084:L3_enriched_AIN-2_IP
      WBPaper00035084:L4_enriched_AIN-2_IP
      WBPaper00035227:heat_shock_regulated
      WBPaper00035560:ahr-1_downregulated
      WBPaper00036123:Cadmium_regulated
      WBPaper00036123:Fluoranthene_regulated
      WBPaper00036286:Pattern_G
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_aging
      WBPaper00040858:eQTL_regulated_reproductive
      WBPaper00040963:Q50_up
      WBPaper00040985:AIN-2_asynchronous_intestine
      WBPaper00041002:HF_11d_2.0mM_Up
      WBPaper00041002:HQ_3d_2.0mM_Down
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00042258:HT115_downregulated_YoungAdult
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00048989:N2_rapamycin_upregulated
      WBPaper00050520:lagr-1(gk327);hyl-1(ok976)_upregulated
      WBPaper00053550:daf-19(m86)_upregulated_L1
      WBPaper00053688:E.faecalis_downregulated
      WBPaper00053688:E.faecium_downregulated
      WBPaper00055435:AuNPs_downregulated
      WBPaper00055435:MUA-AuNP-0.5_downregulated
      WBPaper00055435:MUA-AuNP-3_downregulated
      [cgc5767]:cluster_1
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_MD
      [cgc5767]:expression_class_MD_pd(41_min)
      [cgc5767]:expression_class_SM
      [cgc5767]:expression_class_SMD
    Interaction (110)
  Map_info (3)
  Reference (25)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene