WormBase Tree Display for Gene: WBGene00015512
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| WBGene00015512 | SMap | S_parent | Sequence | C06A8 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | mthf-1 | Person_evidence | WBPerson1711 | |||||
| Sequence_name | C06A8.1 | ||||||||
| Molecular_name | C06A8.1a | ||||||||
| C06A8.1a.1 | |||||||||
| CE30593 | |||||||||
| C06A8.1b | |||||||||
| CE31291 | |||||||||
| C06A8.1b.1 | |||||||||
| C06A8.1b.2 | |||||||||
| Other_name | CELE_C06A8.1 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | mthf-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:30:56 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 20 Apr 2011 10:05:24 | WBPerson2970 | Name_change | CGC_name | mthf-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mthf | ||||||||
| Allele (56) | |||||||||
| Strain | WBStrain00003271 | ||||||||
| WBStrain00037958 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (13) | |||||||||
| Contained_in_operon | CEOP2731 | ||||||||
| Ortholog (38) | |||||||||
| Paralog | WBGene00010988 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| WBGene00020491 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | mthf-1 encodes a gene that is orthologous to human methylenetetrahydrofolate reductase (MTHFR), based on sequence comparison; mthf-1 is among several genes that are upregulated in a gene expression profiling study of the oxidative stress response of aak-2 (homolog of alpha-subunit of AMP-activated protein kinase) mutants. | Paper_evidence | WBPaper00038118 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 20 Sep 2011 00:00:00 | ||||||||
| Automated_description | Predicted to enable FAD binding activity and methylenetetrahydrofolate reductase (NAD(P)H) activity. Predicted to be involved in methionine biosynthetic process and tetrahydrofolate interconversion. Expressed in muscle cell and tail. Used to study lipid metabolism disorder. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); hematologic cancer (multiple); and liver disease (multiple). Is an ortholog of human MTHFR (methylenetetrahydrofolate reductase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:3146 | Homo sapiens | Paper_evidence | WBPaper00054627 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 02 Apr 2019 00:00:00 | ||||||||
| Potential_model (91) | |||||||||
| Disease_relevance | mthf-1 encodes a gene that is orthologous to human methylenetetrahydrofolate reductase (MTHFR); MTHFR catalyses the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, required for the multi-step process that converts homocysteine to methionine, as such MTHFR is involved in Vitamin B-folate metabolism; mutations in MTHFR have been associated with homocystinuria, anencephaly, and spina bifida. | Homo sapiens | Paper_evidence | WBPaper00038118 | |||||
| Accession_evidence | OMIM | 607093 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 27 Sep 2011 00:00:00 | ||||||||
| Models_disease_asserted | WBDOannot00000011 | ||||||||
| Molecular_info | Corresponding_CDS | C06A8.1a | |||||||
| C06A8.1b | |||||||||
| Corresponding_transcript | C06A8.1a.1 | ||||||||
| C06A8.1b.1 | |||||||||
| C06A8.1b.2 | |||||||||
| Other_sequence (37) | |||||||||
| Associated_feature | WBsf650270 | ||||||||
| WBsf650271 | |||||||||
| WBsf665728 | |||||||||
| WBsf665729 | |||||||||
| WBsf665730 | |||||||||
| WBsf665731 | |||||||||
| WBsf665732 | |||||||||
| WBsf223395 | |||||||||
| WBsf223396 | |||||||||
| WBsf223397 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00024482 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00008349 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00028542 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00106993 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00106973 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00064447 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00113898 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00039833 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (12) | |||||||||
| Drives_construct | WBCnstr00002213 | ||||||||
| WBCnstr00003301 | |||||||||
| WBCnstr00004573 | |||||||||
| WBCnstr00028790 | |||||||||
| WBCnstr00042749 | |||||||||
| Construct_product | WBCnstr00028790 | ||||||||
| WBCnstr00042749 | |||||||||
| Microarray_results (25) | |||||||||
| Expression_cluster (195) | |||||||||
| Interaction (21) | |||||||||
| Map_info | Map | II | Position | 0.562008 | Error | 0.000381 | |||
| Positive | Positive_clone | C06A8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (12) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
