mthf-1 encodes a gene that is orthologous to human methylenetetrahydrofolate reductase (MTHFR), based on sequence comparison; mthf-1 is among several genes that are upregulated in a gene expression profiling study of the oxidative stress response of aak-2 (homolog of alpha-subunit of AMP-activated protein kinase) mutants.
Predicted to enable FAD binding activity and methylenetetrahydrofolate reductase (NAD(P)H) activity. Predicted to be involved in methionine biosynthetic process and tetrahydrofolate interconversion. Expressed in muscle cell and tail. Used to study lipid metabolism disorder. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); hematologic cancer (multiple); and liver disease (multiple). Is an ortholog of human MTHFR (methylenetetrahydrofolate reductase).
mthf-1 encodes a gene that is orthologous to human methylenetetrahydrofolate reductase (MTHFR); MTHFR catalyses the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, required for the multi-step process that converts homocysteine to methionine, as such MTHFR is involved in Vitamin B-folate metabolism; mutations in MTHFR have been associated with homocystinuria, anencephaly, and spina bifida.
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.