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WormBase Tree Display for Gene: WBGene00015512

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Name Class

WBGene00015512SMapS_parentSequenceC06A8
IdentityVersion2
NameCGC_namemthf-1Person_evidenceWBPerson1711
Sequence_nameC06A8.1
Molecular_nameC06A8.1a
C06A8.1a.1
CE30593
C06A8.1b
CE31291
C06A8.1b.1
C06A8.1b.2
Other_nameCELE_C06A8.1Accession_evidenceNDBBX284602
Public_namemthf-1
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change128 May 2004 13:30:56WBPerson1971EventImportedInitial conversion from CDS class of stlace from WS125
220 Apr 2011 10:05:24WBPerson2970Name_changeCGC_namemthf-1
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classmthf
Allele (56)
StrainWBStrain00003271
WBStrain00037958
RNASeq_FPKM (74)
GO_annotation (13)
Contained_in_operonCEOP2731
OrthologWBGene00057681Caenorhabditis remaneiFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00033813Caenorhabditis briggsaeFrom_analysisOrthoMCL
OMA
Inparanoid_8
WormBase-Compara
WBGene00210484Caenorhabditis japonicaFrom_analysisTreeFam
WormBase-Compara
WBGene00191627Caenorhabditis brenneriFrom_analysisTreeFam
Inparanoid_8
WormBase-Compara
WBGene00129442Caenorhabditis japonicaFrom_analysisInparanoid_8
WormBase-Compara
WBGene00033814Caenorhabditis briggsaeFrom_analysisWormBase-Compara
WBGene00222260Brugia malayiFrom_analysisWormBase-Compara
CBOVI.g12455Caenorhabditis bovisFrom_analysisWormBase-Compara
CSP21.g2015Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP26.g16592Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP28.g14646Caenorhabditis panamensisFrom_analysisWormBase-Compara
CSP29.g20114Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP31.g9697Caenorhabditis uteleiaFrom_analysisWormBase-Compara
CSP32.g4423Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP38.g9725Caenorhabditis quiockensisFrom_analysisWormBase-Compara
CSP39.g29359Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP40.g17103Caenorhabditis tribulationisFrom_analysisWormBase-Compara
Cang_2012_03_13_00844.g14519Caenorhabditis angariaFrom_analysisWormBase-Compara
Cni-mthf-1Caenorhabditis nigoniFrom_analysisWormBase-Compara
Csp11.Scaffold504.g2393Caenorhabditis tropicalisFrom_analysisWormBase-Compara
Csp5_scaffold_00159.g5911Caenorhabditis sinicaFrom_analysisWormBase-Compara
FL83_06939Caenorhabditis latensFrom_analysisWormBase-Compara
GCK72_005714Caenorhabditis remaneiFrom_analysisWormBase-Compara
OTIPU.nOt.2.0.1.g07796Oscheius tipulaeFrom_analysisWormBase-Compara
Pan_g20766Panagrellus redivivusFrom_analysisWormBase-Compara
Sp34_20144400Caenorhabditis inopinataFrom_analysisWormBase-Compara
chrII_pilon.g5095Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00248398Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00105562Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00263678Strongyloides rattiFrom_analysisWormBase-Compara
WBGene00294860Trichuris murisFrom_analysisWormBase-Compara
SGD:S000003093Saccharomyces cerevisiaeFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
SGD:S000005944Saccharomyces cerevisiaeFrom_analysisEnsEMBL-Compara
OrthoFinder
Panther
PhylomeDB
FB:FBgn0036157Drosophila melanogasterFrom_analysisEnsEMBL-Compara
OrthoFinder
OrthoInspector
Panther
SonicParanoid
ZFIN:ZDB-GENE-041111-215Danio rerioFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
HGNC:7436Homo sapiensFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
MGI:106639Mus musculusFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
RGD:1309952Rattus norvegicusFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
ParalogWBGene00010988Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00020491Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionmthf-1 encodes a gene that is orthologous to human methylenetetrahydrofolate reductase (MTHFR), based on sequence comparison; mthf-1 is among several genes that are upregulated in a gene expression profiling study of the oxidative stress response of aak-2 (homolog of alpha-subunit of AMP-activated protein kinase) mutants.Paper_evidenceWBPaper00038118
Curator_confirmedWBPerson324
WBPerson1823
WBPerson567
Date_last_updated20 Sep 2011 00:00:00
Automated_descriptionPredicted to enable FAD binding activity and methylenetetrahydrofolate reductase (NAD(P)H) activity. Predicted to be involved in methionine biosynthetic process and tetrahydrofolate interconversion. Expressed in muscle cell and tail. Used to study lipid metabolism disorder. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); hematologic cancer (multiple); and liver disease (multiple). Is an ortholog of human MTHFR (methylenetetrahydrofolate reductase).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:3146Homo sapiensPaper_evidenceWBPaper00054627
Curator_confirmedWBPerson324
Date_last_updated02 Apr 2019 00:00:00
Potential_model (91)
Disease_relevancemthf-1 encodes a gene that is orthologous to human methylenetetrahydrofolate reductase (MTHFR); MTHFR catalyses the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, required for the multi-step process that converts homocysteine to methionine, as such MTHFR is involved in Vitamin B-folate metabolism; mutations in MTHFR have been associated with homocystinuria, anencephaly, and spina bifida.Homo sapiensPaper_evidenceWBPaper00038118
Accession_evidenceOMIM607093
Curator_confirmedWBPerson324
Date_last_updated27 Sep 2011 00:00:00
Models_disease_assertedWBDOannot00000011
Molecular_infoCorresponding_CDSC06A8.1a
C06A8.1b
Corresponding_transcriptC06A8.1a.1
C06A8.1b.1
C06A8.1b.2
Other_sequence (37)
Associated_featureWBsf650270
WBsf650271
WBsf665728
WBsf665729
WBsf665730
WBsf665731
WBsf665732
WBsf223395
WBsf223396
WBsf223397
Experimental_infoRNAi_resultWBRNAi00024482Inferred_automaticallyRNAi_primary
WBRNAi00008349Inferred_automaticallyRNAi_primary
WBRNAi00028542Inferred_automaticallyRNAi_primary
WBRNAi00106993Inferred_automaticallyRNAi_primary
WBRNAi00106973Inferred_automaticallyRNAi_primary
WBRNAi00064447Inferred_automaticallyRNAi_primary
WBRNAi00113898Inferred_automaticallyRNAi_primary
WBRNAi00039833Inferred_automaticallyRNAi_primary
Expr_pattern (12)
Drives_constructWBCnstr00002213
WBCnstr00003301
WBCnstr00004573
WBCnstr00028790
WBCnstr00042749
Construct_productWBCnstr00028790
WBCnstr00042749
Microarray_results (25)
Expression_cluster (195)
Interaction (21)
Map_infoMapIIPosition0.562008Error0.000381
PositivePositive_cloneC06A8Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (12)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene