WormBase Tree Display for Gene: WBGene00010700

WBGene00010700 SMap: S_parent: Sequence: K09A9
  Identity: Version: 2
    Name: CGC_name: nipi-3 Person_evidence: WBPerson168
      Sequence_name: K09A9.1
      Molecular_name: K09A9.1
        K09A9.1.1
        CE42581
      Other_name: CELE_K09A9.1 Accession_evidence: NDB BX284606
      Public_name: nipi-3
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:51 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 17 Apr 2008 15:10:27 WBPerson2970 Name_change: CGC_name: nipi-3
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: nipi
    Allele (47)
    Strain: WBStrain00003315
      WBStrain00021982
      WBStrain00021978
    RNASeq_FPKM (74)
    GO_annotation (20)
    Ortholog (28)
    Paralog: WBGene00007007 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00010681 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00011304 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: nipi-3 encodes a kinase similar to the human kinase Tribbles homolog 1; nipi-3 functions in the innate immune response, likely upstream of the SEK-1 MAPKK, to upregulate expression of NLP-29, an antimicrobial peptide, in response to fungal infection. Paper_evidence: WBPaper00031666
          Curator_confirmed: WBPerson1843
          Date_last_updated: 04 Feb 2011 00:00:00
      Automated_description: Enables DNA-binding transcription factor binding activity. Involved in defense response to other organism and regulation of gene expression. Predicted to be located in nucleus. Expressed in CAN; hypodermis; motor neurons; pharynx; and touch receptor neurons. Is an ortholog of human TRIB1 (tribbles pseudokinase 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: K09A9.1
    Corresponding_CDS_history (2)
    Corresponding_transcript: K09A9.1.1
    Other_sequence: CR04824
      CRC00651_1
      CBC12317_1
      CJC06811_1
      CR06179
    Associated_feature (8)
  Experimental_info: RNAi_result (27)
    Expr_pattern: Chronogram892
      Expr6374
      Expr8070
      Expr12563
      Expr13665
      Expr1027431
      Expr1034682
      Expr1154069
      Expr2014263
      Expr2032503
    Drives_construct: WBCnstr00000508
      WBCnstr00003786
      WBCnstr00006335
      WBCnstr00007217
      WBCnstr00013088
      WBCnstr00031209
    Construct_product: WBCnstr00000508
      WBCnstr00006335
      WBCnstr00007219
      WBCnstr00007220
      WBCnstr00007221
      WBCnstr00007222
      WBCnstr00031209
    Regulate_expr_cluster: WBPaper00050515:nipi-3(fr4)_downregulated
      WBPaper00050515:nipi-3(fr4)_upregulated
    Microarray_results (24)
    Expression_cluster: WBPaper00032031:DConiospora_upregulated_cDNA_24h
      WBPaper00032976:dosage_compensated_genes
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037055:DAF-16_binding_DNA
      WBPaper00037682:sma-2_upregulated
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:dopaminergic-neurons_larva_enriched
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_larva_enriched
      WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00040560:hpl-2_embryo_upregulated
      WBPaper00042561:smgl-1(RNAi)_upregulated
      WBPaper00044316:CH3HgCl_7.5uM_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045257:bar-1(ga80)_upregulated
      WBPaper00045314:S.aureus-induced_hlh-30(tm1978)
      WBPaper00045316:prg-1_upregulated_L1
      WBPaper00045521:Oogenic
      WBPaper00045571:germline-ablation_upregulated
      WBPaper00045774:clk-1_downregulated
      WBPaper00045974:NSM_enriched_totalRNA_RNAseq
      WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_downregulated
      WBPaper00046337:polysomal_N2_vs_daf-2_downregulated
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h
      WBPaper00046805:csr-1(RNAi)_downregulated_Set1
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050094:mes-2(bn11)_upregulated
      WBPaper00050094:mes-6(bn66)_upregulated
      WBPaper00050121:mir-60(n4947)_upregulated
      WBPaper00050199:hsf-1(ok600)_upregulated
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050412:cco-1(RNAi)_upregulated_N2
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C
      WBPaper00050514:CEBP-1_interacting
      WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050903:mir-35-41(nDf50)_25C_upregulated
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(ot267)_downregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq
      WBPaper00053321:embryo-to-L1_upregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
      WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055386:daf-2(e1370)_downregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00055941:atfs-1(et15)_upregulated
      WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated
      WBPaper00055941:nuo-6(qm200)_upregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056034:pals-25(jy9)_upregulated
      WBPaper00056039:efa-6(tm3124)_upregulated
      WBPaper00056039:ptl-1(ok621)_upregulated
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056161:hermaphrodite_enriched_siRNA
      WBPaper00056290:hsp-6(mg585)_upregulated
      WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected
      WBPaper00056443:DietaryRestriction_upregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056855:his-72(uge40)_upregulated
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057154:HeatShock_downregulated_miRNA-target
      WBPaper00057154:HeatShock_upregulated_mRNA
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00058691:WDR-5.1_interacting_protein
      WBPaper00058725:sftb-1(cer6)_upregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059203:CAR-1_interacting
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059471:EGL-43_interacting
      WBPaper00059604:fluvastatin_downregulated_dlk-1(km12)
      WBPaper00059604:fluvastatin_downregulated_N2
      WBPaper00059763:neuron_expressed
      WBPaper00059987:Wounding_upregulated
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061340:RID_parent
      WBPaper00061527:acy-2-F35C5.11
      WBPaper00061527:fbxa-154_11499-Y44A6D.1
      WBPaper00061527:ldb-1_2877-scd-1_3086
      WBPaper00061651:ASI_enriched
      WBPaper00061651:VB01_enriched
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00062056:lin-35(n745)_upregulated
      WBPaper00062103:neuron_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:etr-1(lq61)_upregulated
      WBPaper00062345:bortezomib_4h_upregulated_N2
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064107:lin-35(n745)_upregulated
      WBPaper00064122:vulva_transcriptome
      WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated
      WBPaper00064315:mes-3(bn199)_upregulated_EGCs
      WBPaper00064315:mes-3(bn199)_upregulated_PGCs
      WBPaper00064315:mes-4(bn73)_upregulated_EGCs
      WBPaper00064315:mes-4(bn73)_upregulated_PGCs
      WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
      WBPaper00064494:postdauer_upregulated_AWA
      WBPaper00064539:nhr-114(gk849)_upregulated
      WBPaper00064637:cox-5B(RNAi)_upregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065749:Heat-Shock-With-Recovery_upregulated_N2
      WBPaper00065835:Day11_vs_Day1_upregulated
      WBPaper00065835:mtH2S-AP39-D0-treatment_downregulated_Day11
      WBPaper00065841:13_0
      WBPaper00065975:P-body_vs_oocyte_enriched
      WBPaper00065975:P-body_vs_WholeAnimal_enriched
      WBPaper00066062:xrep-4(lax137)_upregulated
      cgc4489_group_20
      WBPaper00025032:cluster_30
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00027111:rde-3(ne298)_upregulated
      WBPaper00027342:alpha-Synuclein(A53T)_downregulated
      WBPaper00028483:Up_mes-4_vs_WT
      WBPaper00029437:dcr-1_upregulated
      WBPaper00031003:hlh_1_enriched
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00032165:A_to_C_transit_increased
      WBPaper00035084:embryo_enriched_AIN-2_IP
      WBPaper00035227:heat_shock_regulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036130:mir-243_up_regulated
      WBPaper00036286:Pattern_F
      WBPaper00037695:WC_5-day
      WBPaper00040963:TA200_down
      WBPaper00040963:TA300_down
      WBPaper00041370:spg-7(RNAi)_upregulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00042574:JU1580_OrsayVirus_upregulated
      WBPaper00044013:nasp-1_downregulated
      WBPaper00045263:isp-1(qm150)_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00046548:dafachronic-acid_downregulated
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00047070:xpa-1_UV_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00050515:nipi-3(fr4)_upregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00053827:pyoverdine_upregulated
      WBPaper00055899:nitroguanidine_regulated
      [cgc5767]:cluster_90
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_ET
      [cgc5767]:expression_class_ET_max(143_min)
      [cgc5767]:expression_class_E_pi(101_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc5767]:expression_class_MET
      [cgc6390]:Cluster_A
    Interaction (13)
    WBProcess: WBbiopr:00000001
      WBbiopr:00000039
  Map_info: Map: X Position: 22.9309 Error: 0.001583
    Positive: Positive_clone: K09A9 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (18)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene