WormBase Tree Display for Gene: WBGene00007007

WBGene00007007 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: C44C8
  Identity: Version: 1
    Name: CGC_name: mak-2 Person_evidence: WBPerson1315
      Sequence_name: C44C8.6
      Molecular_name: C44C8.6
        C44C8.6.1
        CE33566
        C44C8.6.2
      Other_name: CELE_C44C8.6 Accession_evidence: NDB BX284604
      Public_name: mak-2
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 22 Apr 2004 15:45:33 WBPerson1845 Event: Created
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: mak
    Allele (102)
    Strain: WBStrain00032540
      WBStrain00037324
    RNASeq_FPKM (74)
    GO_annotation (42)
    Ortholog (31)
    Paralog: WBGene00010681 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00011304 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00010700 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: mak-2 encodes a serine/threonine protein kinase that is orthologous to the vertebrate MAPKAPK2 and MAPKAPK3 (MAP kinase-activated protein kinase family members 2 and 3) kinases. Curator_confirmed: WBPerson1843
          Date_last_updated: 09 Feb 2009 00:00:00
      Automated_description: Enables mitogen-activated protein kinase binding activity. Involved in several processes, including behavioral response to nicotine; positive regulation of 3'-UTR-mediated mRNA stabilization; and regulation of axon extension. Located in cytoplasm; nucleus; and synapse. Expressed in body wall musculature; intestine; and pharynx. Human ortholog(s) of this gene implicated in patterned macular dystrophy 3. Is an ortholog of human MAPKAPK2 (MAPK activated protein kinase 2) and MAPKAPK3 (MAPK activated protein kinase 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0060865 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6888)
  Molecular_info: Corresponding_CDS: C44C8.6
    Corresponding_CDS_history: C44C8.6a:wp239
      C44C8.6b:wp96
    Corresponding_transcript: C44C8.6.1
      C44C8.6.2
    Other_sequence (74)
    Associated_feature (11)
  Experimental_info: RNAi_result: WBRNAi00042479 Inferred_automatically: RNAi_primary
      WBRNAi00113219 Inferred_automatically: RNAi_primary
      WBRNAi00112989 Inferred_automatically: RNAi_primary
      WBRNAi00029805 Inferred_automatically: RNAi_primary
      WBRNAi00087959 Inferred_automatically: RNAi_primary
      WBRNAi00080232 Inferred_automatically: RNAi_primary
      WBRNAi00042478 Inferred_automatically: RNAi_primary
      WBRNAi00011947 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr11314
      Expr12278
      Expr12815
      Expr12816
      Expr1026418
      Expr1032997
      Expr1146463
      Expr2013359
      Expr2031591
    Drives_construct: WBCnstr00007344
      WBCnstr00018764
      WBCnstr00020568
      WBCnstr00034043
    Construct_product (12)
    Microarray_results (27)
    Expression_cluster (149)
    Interaction (38)
    WBProcess: WBbiopr:00000117
  Map_info: Map: IV Position: -23.1864 Error: 0.025586
    Positive: Positive_clone: C44C8 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (12)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene