WormBase Tree Display for Gene: WBGene00004739

WBGene00004739 SMap: S_parent: Sequence: CHROMOSOME_X
  Identity: Version: 2
    Name: CGC_name: scd-1 Person_evidence: WBPerson655
      Sequence_name: H20J18.1
      Molecular_name (28)
      Other_name: CELE_H20J18.1 Accession_evidence: NDB BX284606
      Public_name: scd-1
    DB_info: Database: AceView gene XN124
        WormQTL gene WBGene00004739
        WormFlux gene WBGene00004739
        NDB locus_tag CELE_H20J18.1
        Panther gene CAEEL|WormBase=WBGene00004739|UniProtKB=Q9XXK5
          family PTHR44240
        NCBI gene 181408
        RefSeq protein NM_001373534.4
            NM_001381122.2
            NM_001381123.3
            NM_001381121.2
            NM_171974.8
            NM_001381120.2
            NM_001373531.3
            NM_001373535.3
        TREEFAM TREEFAM_ID TF350258
        TrEMBL UniProtAcc A0A4V0IN69
            A0A4V0INV4
            A0A4V0IKH6
            A0A4V0IL24
            Q8MQ12
            A0A4V0IKL1
            Q9XXK5
            A0A4V0INN2
        UniProt_GCRP UniProtAcc A0A4V0IN69
    Species: Caenorhabditis elegans
    History: Version_change (2)
      Acquires_merge: WBGene00007634
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: scd
    Allele (382)
    Legacy_information: [Inoue T] suppressor of daf-14
    Complementation_data: [Inoue T] complements daf-3(e1376), daf-12(m20), daf-12(m25)
    Strain: WBStrain00003096
      WBStrain00022787
      WBStrain00054730
    RNASeq_FPKM (74)
    GO_annotation: 00003894
    Ortholog (23)
    Structured_description: Concise_description: scd-1 encodes a novel protein with several regions that are extremely glutamine (Q) rich, interspersed with other residues (usually alanine); SCD-1 affects signalling by proteins in the DAF-7/transforming growth factor (TGF)-beta pathway (DAF-1, DAF-8, and DAF-14), and the Q-rich regions of SCD-1 protein may mediate epigenetic changes of stably heritable tertiary conformation. Paper_evidence: WBPaper00004404
            WBPaper00005068
            WBPaper00012788
            WBPaper00012830
            WBPaper00012882
            WBPaper00012897
            WBPaper00013003
            WBPaper00017938
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enriched in several structures, including ABalppppppa; ABpraaapppa; head mesodermal cell; neurons; and pharyngeal cell based on Chronogram; microarray; RNA-seq; tiling array; and single-cell RNA-seq studies. Is affected by several genes including daf-16; daf-2; and daf-12 based on microarray; tiling array; RNA-seq; and proteomic studies. Is affected by nineteen chemicals including 1-methylnicotinamide; rotenone; and multi-walled carbon nanotube based on RNA-seq and microarray studies. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: H20J18.1a
      H20J18.1b
      H20J18.1c
      H20J18.1d
      H20J18.1e
      H20J18.1f
      H20J18.1g
      H20J18.1h
    Corresponding_CDS_history: H20J18.1:wp83
    Corresponding_transcript (12)
    Other_sequence (11)
    Associated_feature (29)
  Experimental_info: RNAi_result: WBRNAi00001215 Inferred_automatically: RNAi_primary
      WBRNAi00111737 Inferred_automatically: RNAi_primary
      WBRNAi00015031 Inferred_automatically: RNAi_primary
      WBRNAi00040728 Inferred_automatically: RNAi_primary
      WBRNAi00080823 Inferred_automatically: RNAi_primary
      WBRNAi00049450 Inferred_automatically: RNAi_primary
      WBRNAi00016289 Inferred_automatically: RNAi_primary
      WBRNAi00067975 Inferred_automatically: RNAi_primary
    Expr_pattern (12)
    Drives_construct: WBCnstr00003581
      WBCnstr00033590
      WBCnstr00035418
    Construct_product: WBCnstr00033590
      WBCnstr00035418
    Microarray_results (46)
    Expression_cluster: WBPaper00027339:daf-12(rh273)_downregulated
      WBPaper00029359_1280
      WBPaper00029359_1289
      WBPaper00029359_1304
      WBPaper00029359_1444
      WBPaper00029359_1497
      WBPaper00029359_1504
      WBPaper00029359_1604
      WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037055:DAF-16_binding_DNA
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00041071:spe-44_downregulated
      WBPaper00044260:1-methylnicotinamide_downregulated
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044736:flat_dev_expression
      WBPaper00045316:prg-1_upregulated_L1
      WBPaper00045316:prg-1_upregulated_L2
      WBPaper00045316:prg-1_upregulated_L3
      WBPaper00045316:prg-1_upregulated_L4
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00045774:clk-1_downregulated
      WBPaper00045974:NSM_enriched_DSN-treated_RNAseq
      WBPaper00045974:NSM_enriched_totalRNA_RNAseq
      WBPaper00045974:NSM_enriched_totalRNA_tiling
      WBPaper00048988:neuron_expressed
      WBPaper00049217:DAF-16_upregulated
      WBPaper00049377:MWCNT_downregulated
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00050015:ifg-1(RNAi)_upregulated
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050412:cco-1(RNAi)_upregulated_N2
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051245:intestine_nucleus_expressed
      WBPaper00051245:nucleus_specific
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(icb38)_upregulated
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053302:alovudine_72h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053599:female_vs_male_upregulated
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053814:15C_downregulated_OP50
      WBPaper00054493:hpl-2(tm1489)_upregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00055482:Tunicamycin_downregulated
      WBPaper00055565:AVK_enriched
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056034:pals-25(jy9)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056139:gut-microbiota_downregulated
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056161:hermaphrodite_enriched_siRNA
      WBPaper00056218:daf-16(mu86)_upregulated_Day7
      WBPaper00056284:ints-11(RNAi)_downregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056826:hmc_biased
      WBPaper00056855:his-72(uge40)_downregulated
      WBPaper00057041:unc-70(cas983)_downregulated
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058691:WDR-5.1_interacting_protein
      WBPaper00058942:henn-1(pk2295)_upregulated
      WBPaper00058958:100mGy-irradiation-72h_upregulated
      WBPaper00058969:RIS_enriched
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059471:EGL-43_interacting
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060100:SiNP_upregulated_mRNA
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:ASE_parent
      WBPaper00061340:g1A_g1P
      WBPaper00061340:mc1
      WBPaper00061340:Pharyngeal_marginal_cell
      WBPaper00061340:T
      WBPaper00061405:S.aureus_downregulated_starvation
      WBPaper00061527:chd-7_16664-jmjd-3.1
      WBPaper00061527:ldb-1_2877-scd-1_3086
      WBPaper00061527:sre-33-ZK1025.1_8337
      WBPaper00061651:AVK_enriched
      WBPaper00061651:PVW_enriched
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00062103:neuron_enriched
      WBPaper00062146:MOG-7-degron_2h_regulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062590:Aging_downregulated_hypodermis
      WBPaper00064055:trl-1(cas1077)_upregulated_starved
      WBPaper00064130:Beta-Amyloid_downregulated_protein
      WBPaper00064156:lbp-3(overexpress)_upregulated
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064509:static-magnetic-field_downregulated
      WBPaper00064871:hypoxia_downregulated_F3
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065746:eat-2(ad1113)_upregulated
      WBPaper00065841:70_0
      WBPaper00065841:74_0
      WBPaper00065841:76_0
      WBPaper00065841:108_0
      WBPaper00065841:122_0
      WBPaper00065975:P-body_vs_WholeAnimal_enriched
      WBPaper00065993:glp-1(e2141)_upregulated
      cgc4386_cluster_5_1
      cgc4386_cluster_6_4
      cgc4489_group_14
      cgc4489_group_18
      cgc4489_group_20
      WBPaper00025032:cluster_10
      WBPaper00025032:cluster_17
      WBPaper00025032:cluster_25
      WBPaper00025032:cluster_71
      WBPaper00025099:MA_specific
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:hlh_1_enriched
      WBPaper00031003:total_muscle_depleted
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00031532:Larva_Pan_Neuronal_Enriched
      WBPaper00031832:slr-2_regulated
      WBPaper00034661:AgNPs_downregulated
      WBPaper00035084:L1_enriched_AIN-2_IP
      WBPaper00035084:L2_enriched_AIN-2_IP
      WBPaper00035905:FBF-1_Associated
      WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.5
      WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
      WBPaper00040821:Au-NP_regulated
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_regulated_old
      WBPaper00040963:TA300_down
      WBPaper00040985:AIN-2_L4_intestine
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_EtBr-exposed_51h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00045263:isp-1(qm150)_downregulated
      WBPaper00045960:L4-lethargus_upregulated
      WBPaper00046548:dafachronic-acid_downregulated
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00053236:daf-16(mgDF50)_regulated_Starved
      WBPaper00053236:Starvation_regulated_N2
      [cgc5767]:cluster_4
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_ET
      [cgc5767]:expression_class_ET_max(143_min)
      [cgc5767]:expression_class_E_pi(53_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc5767]:expression_class_MET
      [cgc5767]:expression_class_SM
      [cgc5976]:class_1
      [cgc6390]:Cluster_A
    Interaction (47)
  Map_info: Map: X Position: 7.13772 Error: 0.028432
    Well_ordered
    Positive: Positive_clone: F45E6 Author_evidence: Ailion EMM
        H20J18 Inferred_automatically: From sequence, transcript, pseudogene data
    Negative: Outside_rearr: nDf19
    Mapping_data: 2_point: 7100
        7105
        7106
      Multi_point: 3815
        3816
        3817
        3818
        3820
      Pos_neg_data: 10263
  Reference: WBPaper00004404
    WBPaper00004925
    WBPaper00006103
    WBPaper00010911
    WBPaper00017938
    WBPaper00023261
    WBPaper00027315
    WBPaper00033162
    WBPaper00033845
  Method: Gene