WormBase Tree Display for Gene: WBGene00004061

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WBGene00004061	Evidence	Person_evidence	WBPerson583
			WBPerson36
		CGC_data_submission
	SMap	S_parent	Sequence	C06A12
	Identity	Version	1
		Name	CGC_name	pmp-4	Person_evidence	WBPerson36
			Sequence_name	T02D1.5
			Molecular_name	T02D1.5
				T02D1.5.1
				CE16325
			Other_name (2)
			Public_name	pmp-4
		DB_info	Database	AceView	gene	4S346
				WormQTL	gene	WBGene00004061
				NDB	locus_tag	CELE_T02D1.5
				Panther	gene	CAEEL\|WormBase=WBGene00004061\|UniProtKB=O45730
					family	PTHR11384
				NCBI	gene	24104835
				RefSeq	protein	NM_001306751.3
				TREEFAM	TREEFAM_ID	TF105205
				TrEMBL	UniProtAcc	O45730
				UniProt_GCRP	UniProtAcc	O45730
				OMIM	gene	300371
		Species	Caenorhabditis elegans
		History	Version_change	1	07 Apr 2004 11:29:34	WBPerson1971	Event	Imported	Initial conversion from geneace
		Status	Live
	Gene_info	Biotype	SO:0001217
		Gene_class	pmp
		Allele (108)
		Strain	WBStrain00001302
			WBStrain00031414
			WBStrain00035573
		RNASeq_FPKM (74)
		GO_annotation (16)
		Ortholog (42)
		Paralog	WBGene00004058	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00004059	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00004060	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00004062	Caenorhabditis elegans	From_analysis	Panther
						WormBase-Compara
		Structured_description	Concise_description	The pmp-4 gene encodes a homolog of human ALD, which when mutated leads to X-linked adrenoleukodystrophy (OMIM:300100).	Paper_evidence	WBPaper00004103
					Curator_confirmed	WBPerson567
					Date_last_updated	17 Jun 2004 00:00:00
			Automated_description	Predicted to enable ATP binding activity; ATPase-coupled transmembrane transporter activity; and long-chain fatty acid transporter activity. Predicted to be involved in fatty acid catabolic process; long-chain fatty acid import into peroxisome; and peroxisome organization. Predicted to be located in peroxisomal membrane. Used to study adrenoleukodystrophy. Human ortholog(s) of this gene implicated in adrenoleukodystrophy. Is an ortholog of human ABCD1 (ATP binding cassette subfamily D member 1) and ABCD2 (ATP binding cassette subfamily D member 2).	Paper_evidence	WBPaper00065943
					Curator_confirmed	WBPerson324
						WBPerson37462
					Inferred_automatically	This description was generated automatically by a script based on data from the WS291 version of WormBase
					Date_last_updated	29 Nov 2023 00:00:00
	Disease_info	Experimental_model	DOID:10588	Homo sapiens	Paper_evidence	WBPaper00059252
					Curator_confirmed	WBPerson324
					Date_last_updated	04 Jan 2021 00:00:00
		Potential_model	DOID:10588	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:61)
	Models_disease_asserted	WBDOannot00000840
		WBDOannot00000841
	Molecular_info	Corresponding_CDS	T02D1.5
		Corresponding_transcript	T02D1.5.1
		Other_sequence (31)
		Associated_feature	WBsf652423
			WBsf668588
			WBsf717215
	Experimental_info	RNAi_result	WBRNAi00018023	Inferred_automatically	RNAi_primary
			WBRNAi00002422	Inferred_automatically	RNAi_primary
			WBRNAi00035055	Inferred_automatically	RNAi_primary
			WBRNAi00052205	Inferred_automatically	RNAi_primary
		Expr_pattern	Expr6572
			Expr15211
			Expr15212
			Expr15213
			Expr1018172
			Expr1031959
			Expr1155835
			Expr2014975
			Expr2033210
		Drives_construct	WBCnstr00002195
			WBCnstr00035715
			WBCnstr00042070
			WBCnstr00042071
			WBCnstr00042089
		Construct_product	WBCnstr00035715
			WBCnstr00042071
			WBCnstr00042089
		Antibody	WBAntibody00002912
		Microarray_results (22)
		Expression_cluster	WBPaper00031040:TGF-beta_adult_upregulated
			WBPaper00033065:cyc-1(RNAi)_downregulated
			WBPaper00035073:mitochondria_protein
			WBPaper00037086:biotin_regulated
			WBPaper00037950:all-neurons_L1-larva_expressed
			WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
			WBPaper00037950:dopaminergic-neurons_larva_enriched
			WBPaper00037950:dopaminergic-neurons_larva_SelectivelyEnriched
			WBPaper00037950:germline-precursors_blastula-embryo_expressed
			WBPaper00037950:hypodermis_L1-larva_expressed
			WBPaper00037950:hypodermis_L3-L4-larva_expressed
			WBPaper00037950:intestine_embryo_enriched
			WBPaper00037950:intestine_embryo_SelectivelyEnriched
			WBPaper00037950:intestine_L1-larva_expressed
			WBPaper00037950:intestine_L2-larva_expressed
			WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
			WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
			WBPaper00038104:DATS_downregulated
			WBPaper00038168:lin-15B(n744)_downregulated
			WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
			WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
			WBPaper00038438:Harposporium_24hr_upregulated_RNAseq
			WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
			WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
			WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
			WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
			WBPaper00041954:ethanol_upregulated
			WBPaper00042561:smgl-1(RNAi)_upregulated
			WBPaper00044260:1-methylnicotinamide_upregulated
			WBPaper00044736:flat_dev_expression
			WBPaper00045861:wdr-5(ok1417)_upregulated
			WBPaper00046303:P.aeruginosa_upregulated_protein
			WBPaper00046415:lithium_downregulated
			WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h
			WBPaper00046691:P1_enriched
			WBPaper00047132:glp-1(ts)-25C_upregulated
			WBPaper00048923:Aging_regulated
			WBPaper00048971:daf-16(mgDf50)_upregulated_L1
			WBPaper00048988:neuron_expressed
			WBPaper00049217:TCER-1_upregulated
			WBPaper00049334:CE_intestine_enriched
			WBPaper00050488:adult_vs_dauer_regulated_N2_20C
			WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
			WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
			WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C
			WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C
			WBPaper00050726:OsmoticStress_regulated_Food
			WBPaper00050726:OsmoticStress_regulated_NoFood
			WBPaper00050801:DAF-16_dauer_regulome
			WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
			WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
			WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
			WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
			WBPaper00050990:intestine_expressed
			WBPaper00050990:seam_expressed
			WBPaper00051039:ash-2(RNAi)_regulated_intestine
			WBPaper00051039:intestine_enriched
			WBPaper00051245:intestine_cytoplasm_expressed
			WBPaper00051257:Levamisole_upregulated
			WBPaper00051265:F4_hrde-1(tm1200)_upregulated
			WBPaper00052868:ALA_upregulated
			WBPaper00052884:emb-4(hc60)_upregulated
			WBPaper00053184:sma-2(rax5)_upregulated
			WBPaper00053184:sma-4(rax3)_upregulated
			WBPaper00053318:mir-71(n4115)_upregulated_mRNA
			WBPaper00053388:dauer_regulated_Cluster5
			WBPaper00053814:15C_downregulated_PY79
			WBPaper00055354:eat-2(ad1116)_downregulated
			WBPaper00055354:Rifampicin-Allantoin_downregulated
			WBPaper00055626:pry-1(mu38)_upregulated
			WBPaper00056034:pals-22(jy3)_upregulated
			WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
			WBPaper00056090:E.faecalis_upregulated_N2
			WBPaper00056284:ints-5(RNAi)_upregulated
			WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
			WBPaper00056471:S.aureus-4h_upregulated_N2
			WBPaper00056826:hmc_biased
			WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
			WBPaper00057006:DietaryRestriction_upregulated
			WBPaper00058598:sin-3(tm1276)_downregulated
			WBPaper00058948:PA14_downregulated
			WBPaper00059117:B.subtilis_upregulated
			WBPaper00059253:sucrose_stearic-acid_upregulated
			WBPaper00059566:wdr-23(mac32)_upregulated
			WBPaper00059567:olrn-1(ums9)_regulated
			WBPaper00059609:malt-1_ilc-17.1_nfki-1_upregulated
			WBPaper00059839:S.maltophilia_regulated
			WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
			WBPaper00060445:ikb-1(nr2027)_upregulated_L1
			WBPaper00060871:M.humicola-extract_1h_regulated
			WBPaper00060909:atfs-1(cmh15)_downregulated
			WBPaper00060911:prx-5(RNAi)_upregulated_mRNA
			WBPaper00060911:prx-5(RNAi)_upregulated_protein
			WBPaper00061007:HB101_upregulated
			WBPaper00061007:HB115_upregulated
			WBPaper00061007:S.aquatilis_upregulated
			WBPaper00061081:E.faecalis_upregulated_skpo-1(ok1640)
			WBPaper00061203:let-418(n3536)_upregulated
			WBPaper00061203:sin-3(tm1276)_upregulated
			WBPaper00061203:spr-1(ok2144)_upregulated
			WBPaper00061274:microgravity_downregulated
			WBPaper00061439:unc-30(ok613)_downregulated
			WBPaper00061753:csr-1(tor159)_upregulated_25C
			WBPaper00062159:hda-2(ok1479)_upregulated
			WBPaper00062167:mbl-1(tm1563)_downregulated
			WBPaper00062325:muscle_depleted_coding-RNA
			WBPaper00062440:crh-1(n3315)_upregulated
			WBPaper00064071:NHR-49_interacting
			WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
			WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
			WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
			WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
			WBPaper00064502:spe-44(fx110)_downregulated
			WBPaper00064632:daf-2(e1370)_upregulated_intestine
			WBPaper00064716:paraquat_downregulated
			WBPaper00064762:freezing-thaw_regulated
			WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
			WBPaper00064939:vit-5(RNAi)_upregulated
			WBPaper00065096:25C_vs_20C_downregulated
			WBPaper00065096:Day10_vs_Day1_downregulated
			WBPaper00065225:nhr-42(tm1375)_upregulated_S.aureus-infected
			WBPaper00065331:100nM-ivermectin_upregulated
			WBPaper00065373:sek-1(km4)_upregulated_Ref
			WBPaper00065392:Lb.delbrueckii_upregulated
			WBPaper00065392:Lb.gasseri_upregulated
			WBPaper00065392:Lb.rhamnosus_upregulated
			WBPaper00065392:P.pentosaceus_upregulated
			WBPaper00065749:endu-2(tm4977)_upregulated
			WBPaper00065749:Heat-Shock-With-Recovery_upregulated_N2
			WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
			WBPaper00065841:35_0
			WBPaper00065841:47_1
			WBPaper00065841:57_0
			WBPaper00065975:P-body_vs_WholeAnimal_depleted
			WBPaper00065993:glp-1(e2141)_upregulated
			WBPaper00066110:tetraploid_vs_diploid_upregulated
			WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
			cgc4489_group_8
			WBPaper00025141:N2_Expressed_Genes
			WBPaper00025141:unc-4::GFP_Expressed_Genes
			WBPaper00026929:sir-2.1_overexpression_regulated
			WBPaper00026980:intestine_enriched
			WBPaper00032062:age_regulated_genes
			WBPaper00035588:alg-1(-)_upregulated
			WBPaper00035873:dpy-9_regulated
			WBPaper00035873:dpy-10_regulated
			WBPaper00036286:Pattern_C
			WBPaper00038304:octr-1_regulated
			WBPaper00038427:lin-54_embryo_changed
			WBPaper00040858:eQTL_regulated_aging
			WBPaper00041002:HQ_3d_0.2mM_Down
			WBPaper00041906:I-4317_vs_OP50_10d
			WBPaper00041939:control_vs_EtBr-exposed_48h
			WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
			WBPaper00045015:acs-3(ft5)_upregulated
			WBPaper00048637:lin-35(n745)_starvation_upregulated
			WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
			WBPaper00048989:N2_rapamycin_upregulated
			WBPaper00050520:lagr-1(gk327);hyl-1(ok976)_upregulated
			WBPaper00053236:daf-16(mgDF50)_regulated_Starved
			WBPaper00053236:Starvation_regulated_N2
			WBPaper00053827:pyoverdine_upregulated
			WBPaper00055899:nitroguanidine_regulated
			[cgc6390]:Cluster_C
		Interaction (100)
	Map_info	Map	IV	Position	16.8463	Error	0.037163
		Positive	Positive_clone	T02D1	Inferred_automatically	From sequence, transcript, pseudogene data
		Mapping_data	Multi_point	4778
				4901
		Pseudo_map_position
	Reference	WBPaper00016821
		WBPaper00027644
		WBPaper00031484
		WBPaper00038491
		WBPaper00047097
		WBPaper00055090
		WBPaper00059252
		WBPaper00060821
		WBPaper00065331
	Remark	Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.	CGC_data_submission
	Method	Gene