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WormBase Tree Display for Gene: WBGene00003607

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Name Class

WBGene00003607EvidencePaper_evidenceWBPaper00003416
WBPaper00004181
SMapS_parentSequenceF33D4
IdentityVersion1
NameCGC_namenhr-8Person_evidenceWBPerson600
Sequence_nameF33D4.1
Molecular_nameF33D4.1a
F33D4.1a.1
CE33927
F33D4.1b
CE33928
F33D4.1b.1
Other_nameCELE_F33D4.1Accession_evidenceNDBBX284604
Public_namenhr-8
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:32WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classnhr
Allele (42)
Legacy_informationNMK. Nuclear hormone receptor superfamily. [AE]
[C.elegansII] NMK. Nuclear hormone receptor superfamily. YAC Y50A3 etc. [AE]
StrainWBStrain00000059
WBStrain00051691
WBStrain00054632
RNASeq_FPKM (74)
GO_annotation (17)
Ortholog (30)
Paralog (19)
Structured_descriptionConcise_descriptionThe nhr-8 gene encodes a nuclear hormone receptor homolog; nhr-8(ok186) mutants have abnormally low resistance to the toxins colchicine and chloroquine.Paper_evidenceWBPaper00004723
Curator_confirmedWBPerson567
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionPredicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Involved in cholesterol homeostasis. Located in nucleus. Expressed in intestinal cell. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); autosomal recessive limb-girdle muscular dystrophy type 2B; carcinoma (multiple); and lung disease (multiple). Is an ortholog of human VDR (vitamin D receptor).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_model (53)
Molecular_infoCorresponding_CDSF33D4.1a
F33D4.1b
Corresponding_CDS_historyF33D4.1a:wp99
F33D4.1b:wp99
Corresponding_transcriptF33D4.1a.1
F33D4.1b.1
Other_sequenceOden_contig20559
Oden_isotig10723
DN558166.1
AYC01323_1
HBC03177_1
LSC01052_1
AE02063
ES414143.1
Associated_featureWBsf646108
WBsf646109
WBsf660331
WBsf660332
WBsf978331
WBsf228565
WBsf228566
Transcription_factorWBTranscriptionFactor000264
Experimental_infoRNAi_result (16)
Expr_patternExpr1351
Expr11216
Expr1023140
Expr1031655
Expr1150089
Expr2014241
Expr2032482
Drives_constructWBCnstr00010232
WBCnstr00036006
Construct_productWBCnstr00010232
WBCnstr00018225
WBCnstr00036006
Regulate_expr_clusterWBPaper00044030:nhr-8(hd117)_downregulated
WBPaper00044030:nhr-8(hd117)_upregulated
WBPaper00062446:nhr-8(hd117)_downregulated
WBPaper00062446:nhr-8(hd117)_upregulated
WBPaper00062446:nhr-8(ok186)_downregulated
WBPaper00062446:nhr-8(ok186)_upregulated
Microarray_results (29)
Expression_clusterWBPaper00032425:down_in_alg-1
WBPaper00033065:cyc-1(RNAi)_upregulated
WBPaper00037950:BAG-neuron_blastula-embryo_expressed
WBPaper00037950:intestine_CoreEnriched
WBPaper00037950:intestine_embryo_enriched
WBPaper00037950:intestine_embryo_SelectivelyEnriched
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00037950:intestine_L2-larva_expressed
WBPaper00037950:intestine_larva_enriched
WBPaper00037950:intestine_larva_SelectivelyEnriched
WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
WBPaper00041370:spg-7(RNAi)_upregulated_atfs-1_dependent
WBPaper00044030:nhr-8(hd117)_downregulated
WBPaper00044316:CH3HgCl_7.5uM_upregulated
WBPaper00044426:rotenone_24h_upregulated
WBPaper00044736:flat_dev_expression
WBPaper00044760:somatic_specific
WBPaper00045774:clk-1_downregulated
WBPaper00046121:endoderm_unique
WBPaper00046338:intestine_unique
WBPaper00046509:lin-35(n745)_downregulated
WBPaper00047132:glp-1(ts)-25C_upregulated
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_expressed
WBPaper00049495:starvation-refeeding_regulated
WBPaper00049942:hsf-1(RNAi)_downregulated
WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo
WBPaper00050344:ASER-neuron_enriched
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050726:starvation_regulated_LowSalt
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00051039:intestine_enriched
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
WBPaper00053606:elt-2(ca15)_vs_elt-2(ca15);elt-7(tm840)_doenregulated
WBPaper00055013:hmg-3(bar24)_downregulated
WBPaper00055013:hmg-4(RNAi)_downregulated
WBPaper00055013:spt-16(RNAi)_downregulated
WBPaper00055060:flr-1(RNAi)_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin_upregulated
WBPaper00055354:Rifampicin_upregulated
WBPaper00055386:eat-2(ad465)_upregulated
WBPaper00055971:nhl-2(ok818)_25C_downregulated
WBPaper00056034:pals-22(jy3)_upregulated
WBPaper00056034:pals-25(jy9)_upregulated
WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
WBPaper00056167:Cry5B_downregulated
WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
WBPaper00056293:rpl-5(0)-rpl-33(0)_downregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
WBPaper00056471:S.aureus-4h_upregulated_N2
WBPaper00056809:smn-1(ok355)_downregulated
WBPaper00056826:hmc_biased
WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
WBPaper00057068:ints-4(RNAi)_downregulated
WBPaper00058598:mex-1(or286)_upregulated
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058598:spn-4(tm291)_upregulated
WBPaper00058691:cfp-1(tm6369)_downregulated
WBPaper00058711:paraquat_downregulated
WBPaper00058948:PA14_downregulated
WBPaper00059027:neuron-synapses_depleted
WBPaper00059567:olrn-1(ums9)_regulated
WBPaper00059609:malt-1_ilc-17.1_nfki-1_downregulated
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00059754:E.faecalis_OG1RF_upregulated
WBPaper00059763:neuron_acr-2(n2420gf)_regulated
WBPaper00059895:wounding_upregulated
WBPaper00060273:isp-1(qm150)_upregulated
WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
WBPaper00060871:M.humicola-extract_1h_regulated
WBPaper00060871:M.humicola-extract_4h_regulated
WBPaper00060909:atfs-1(cmh15)_downregulated
WBPaper00061007:HB101_upregulated
WBPaper00061007:S.aquatilis_upregulated
WBPaper00061007:X.citri_upregulated
WBPaper00061203:let-418(n3536)_upregulated
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061340:Intestine
WBPaper00061479:hda-1(ne4752)_upregulated
WBPaper00061527:F58F9.3_11574-R07B7.6
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062184:PA14_upregulated
WBPaper00062305:P.brevicompactum_upregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062440:crh-1(n3315)_downregulated
WBPaper00062446:nhr-8(hd117)_downregulated
WBPaper00062446:nhr-8(ok186)_downregulated
WBPaper00064005:starvation_upregulated_N2_mRNA
WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
WBPaper00064637:cox-5B(RNAi)_upregulated
WBPaper00064716:paraquat_downregulated
WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
WBPaper00065086:JU1400_N.ausubeli_regulated
WBPaper00065086:JU1400_N.ferruginous_regulated
WBPaper00065086:N2_N.ausubeli_regulated
WBPaper00065096:25C_vs_20C_downregulated
WBPaper00065096:Day10_vs_Day1_downregulated
WBPaper00065835:mtH2S-AP39-D0-treatment_downregulated_Day5
WBPaper00065841:3_4
WBPaper00065841:12_0
WBPaper00065841:26_2
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00065993:glp-1(e2141)_upregulated
WBPaper00066062:xrep-4(lax137)_upregulated
WBPaper00066110:tetraploid_vs_diploid_upregulated
cgc4489_group_8
WBPaper00025099:MA_specific
WBPaper00025141:N2_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00026980:intestine_enriched
WBPaper00027111:rde-3(r459)_upregulated
WBPaper00034757:up_by_oxidative_stress
WBPaper00035873:dpy-9_regulated
WBPaper00035873:dpy-10_regulated
WBPaper00035873:osmotically_regulated
WBPaper00036383:ash-2_L3_regulated
WBPaper00037695:WC_5-day
WBPaper00038304:octr-1_regulated
WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.5
WBPaper00040876:mir-35_downregulated
WBPaper00040963:Q50_down
WBPaper00040963:Q100_down
WBPaper00040963:TA100_up
WBPaper00040963:TA300_up
WBPaper00041002:HF_3d_0.2mM_Up
WBPaper00041002:HF_3d_2.0mM_Up
WBPaper00041002:HQ_3d_2.0mM_Up
WBPaper00041370:spg-7(RNAi)_upregulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_EtBr-exposed_24h
WBPaper00041939:control_vs_UVC-EtBr-exposed_3h
WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h
WBPaper00041960:daf-16_fasting_upregulated
WBPaper00041960:jun-1_fasting_upregulated
WBPaper00041960:kgb-1_fasting_upregulated
WBPaper00041960:N2_fasting_upregulated
WBPaper00041960:N2_fasting_upregulated_anytime
WBPaper00046853:AOBr_M.aeruginosa-batch-culture_downregulated
WBPaper00047070:N2_UV_upregulated
WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO
WBPaper00048989:N2_allantoin_downregulated
WBPaper00048989:N2_rapamycin_downregulated
WBPaper00053236:Starvation_regulated_N2
WBPaper00056330:mrps-5(RNAi)_upregulated
[cgc6390]:Cluster_C
[cgc6390]:herm_soma-enriched
Interaction (68)
WBProcessWBbiopr:00000001
WBbiopr:00000121
Map_infoMapIVPosition3.41773Error0.007272
PositivePositive_cloneF33D4Inferred_automaticallyFrom sequence, transcript, pseudogene data
Y50A3Person_evidenceWBPerson600
Y53H2Person_evidenceWBPerson600
Y54E12Person_evidenceWBPerson600
Mapping_dataMulti_point4520
Pseudo_map_position
Reference (53)
Remarkcm14e12 unnecessary in sequence list. sdm 11/00
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene