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WormBase Tree Display for Gene: WBGene00001725

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Name Class

WBGene00001725EvidencePaper_evidenceWBPaper00003717
SMapS_parentSequenceY65B4BR
IdentityVersion1
NameCGC_namegrl-16Person_evidenceWBPerson83
Sequence_nameY65B4BR.6
Molecular_nameY65B4BR.6a
Y65B4BR.6a.1
CE25541
Y65B4BR.6b
CE33240
Y65B4BR.6b.1
Other_nameY65B4BR.mCurator_confirmedWBPerson1983
RemarkOld cosmid naming mapped via unique overlapping PCR_product on CDSs
CELE_Y65B4BR.6Accession_evidenceNDBBX284601
Public_namegrl-16
DB_infoDatabaseAceViewgene1B46
WormQTLgeneWBGene00001725
WormFluxgeneWBGene00001725
NDBlocus_tagCELE_Y65B4BR.6
PanthergeneCAEEL|WormBase=WBGene00001725|UniProtKB=H2L083
familyPTHR23261
NCBIgene171649
RefSeqproteinNM_182075.3
NM_058353.6
TREEFAMTREEFAM_IDTF315611
TrEMBLUniProtAccQ9N2Z3
H2L083
UniProt_GCRPUniProtAccH2L083
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:25WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classgrl
Allele (84)
StrainWBStrain00032865
RNASeq_FPKM (74)
Ortholog (21)
Paralog (32)
Structured_descriptionConcise_descriptiongrl-16 encodes, by alternative splicing, two hedgehog-like proteins withan N-terminal signal sequence, a central proline-rich low-complexityregion, and a C-terminal Ground-like (Grl) domain; the Grl domain ispredicted to form a cysteine-crosslinked protein involved inintercellular signalling, and it has subtle similarity to the N-terminalHedge domain of HEDGEHOG proteins.Paper_evidenceWBPaper00003717
WBPaper00026841
WBPaper00027263
Curator_confirmedWBPerson567
Date_last_updated05 Nov 2006 00:00:00
Automated_descriptionEnriched in several structures, including arc ant V; germ line; hypodermis; neurons; and rectal epithelial cell based on proteomic; tiling array; RNA-seq; single-cell RNA-seq; and microarray studies. Is affected by several genes including daf-16; daf-2; and skn-1 based on microarray; proteomic; and RNA-seq studies. Is affected by twenty-four chemicals including hydrogen sulfide; 1-methylnicotinamide; and nicotinic acid based on microarray and RNA-seq studies. Is predicted to encode a protein with the following domain: Ground-like domain.Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSY65B4BR.6a
Y65B4BR.6b
Corresponding_CDS_historyY65B4BR.6c:wp272
Corresponding_transcriptY65B4BR.6a.1
Y65B4BR.6b.1
Other_sequence (97)
Associated_featureWBsf648911
WBsf663874
WBsf717443
WBsf982538
WBsf982539
WBsf982540
WBsf1009099
WBsf1009100
WBsf218920
Experimental_infoRNAi_resultWBRNAi00037711Inferred_automaticallyRNAi_primary
Expr_patternExpr4423
Expr1018184
Expr1031030
Expr1161350
Expr2012250
Expr2030486
Drives_constructWBCnstr00011985
WBCnstr00036736
Construct_productWBCnstr00036736
Microarray_results (23)
Expression_clusterWBPaper00028451:Oogenic_protein
WBPaper00031040:TGF-beta_adult_upregulated
WBPaper00033065:clk-1(qm30)_upregulated
WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
WBPaper00037950:bodywall-muscle_L1-larva_expressed
WBPaper00037950:coelomocytes_L2-larva_expressed
WBPaper00037950:germline-precursors_blastula-embryo_expressed
WBPaper00037950:germline-precursors_embryo_enriched
WBPaper00037950:germline-precursors_embryo_SelectivelyEnriched
WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
WBPaper00037950:hypodermis_embryo_enriched
WBPaper00037950:hypodermis_embryo_SelectivelyEnriched
WBPaper00037950:hypodermis_L1-larva_expressed
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
WBPaper00038118:stress_upregulated_N2
WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
WBPaper00040134:nhr-49(RNAi)_regulated_protein
WBPaper00040209:B.thuringiensis_downregulated_MY15
WBPaper00040209:B.thuringiensis_downregulated_MY18
WBPaper00040285:H2S_12hr_downregulated
WBPaper00040285:H2S_24hr_downregulated
WBPaper00042215:wdr-23(tm1817)_upregulated
WBPaper00042561:smgl-1(RNAi)_upregulated
WBPaper00044260:1-methylnicotinamide_upregulated
WBPaper00044260:nicotinc-acid_upregulated
WBPaper00044578:reduced-humidity_downregulated_microarray
WBPaper00044736:oscillating_dev_expression
WBPaper00045316:prg-1_downregulated_L1
WBPaper00045417:128Q-huntingtin_downreglated
WBPaper00045521:Gender_Neutral
WBPaper00045774:clk-1_upregulated
WBPaper00045774:clk-1_upregulated_CoQ10_dependent
WBPaper00045934:wrn-1(gk99)_upregulated
WBPaper00046012:tdp-1(ok803)_downregulated
WBPaper00046024:sleep_upregulated_oscillating
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
WBPaper00046497:B.thuringiensis_upregulated_protein
WBPaper00046499:AMPK_regulated
WBPaper00046527:glucose_upregulated
WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
WBPaper00047131:daf-2(e1370)_upregulated_N2-background
WBPaper00047132:glp-1(ts)-25C_upregulated
WBPaper00048988:neuron_expressed
WBPaper00049018:ham-3(RNAi)_downregulated
WBPaper00049334:CE_intestine_enriched
WBPaper00049498:npr-1(ur89)_regulated_3
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
WBPaper00049920:Glucose-Diet_upregulated_N2
WBPaper00049920:hyl-2(tm2031)_upregulated
WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
WBPaper00049942:hsf-1(RNAi)_downregulated
WBPaper00049954:BPS_downregulated
WBPaper00050109:rBmTX14_upregulated
WBPaper00050332:skn-1(RNAi)_downregulated
WBPaper00050344:ASER-neuron_enriched
WBPaper00050370:dpy-21(e428)_L3_downregulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050709:jmjd-1.2(tm3713)_regulated
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050726:OsmoticStress_regulated_NoFood
WBPaper00050726:starvation_regulated_HighSalt
WBPaper00050801:DAF-12_dauer_regulome
WBPaper00050801:DAF-16_dauer_regulome
WBPaper00050801:DPY-21_dauer_regulome
WBPaper00050801:SET-4_dauer_regulome
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00050990:seam_expressed
WBPaper00051265:F1_morc-1(tm6048)_upregulated
WBPaper00051265:F4_hrde-1(tm1200)_downregulated
WBPaper00051265:F4_morc-1(tm6048)_downregulated
WBPaper00051371:Orsay-virus-infection_upregulated_rde-1(ne219)
WBPaper00051404:alg-1(gk214)_upregulated
WBPaper00051404:alg-2(ok304)_upregulated
WBPaper00051558:aging_regulated
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00053023:nrx-1(tm1961);nlg-1(ok259)_upregulated
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053302:alovudine_24h_regulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053302:stavudine_72h_regulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053388:dauer_regulated_Cluster6
WBPaper00053402:cco-1(RNAi)_downregulated
WBPaper00053657:JU2519_M.humicola-infection_12hr
WBPaper00053657:N2_M.humicola-infection_12hr
WBPaper00053810:nuo-6(qm200)_downregulated
WBPaper00054493:hpl-2(tm1489)_upregulated
WBPaper00055013:hmg-3(bar24)_downregulated
WBPaper00055013:hmg-4(RNAi)_downregulated
WBPaper00055049:S.gordonii_upregulated
WBPaper00055354:eat-2(ad1116)_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
WBPaper00055354:Rapamycin_upregulated
WBPaper00055386:daf-2(e1370)_upregulated
WBPaper00055386:eat-2(ad465)_upregulated
WBPaper00055626:pry-1(mu38)_downregulated
WBPaper00055827:pfd-6(gk493446)_downregulated
WBPaper00055941:atfs-1(et15)_upregulated
WBPaper00055941:nuo-6(qm200)_downregulated
WBPaper00055944:C.butyricum_vs_OP50_downregulated
WBPaper00055971:nhl-2(ok818)_20C_downregulated
WBPaper00055971:nhl-2(ok818)_25C_downregulated
WBPaper00055981:fog-2(q71)_downregulated
WBPaper00056034:pals-22(jy3)_upregulated
WBPaper00056039:ptl-1(ok621)_downregulated
WBPaper00056039:ptrn-1(tm5597)_downregulated
WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
WBPaper00056090:E.faecalis_upregulated_N2
WBPaper00056090:hpx-2(dg047)_upregulated_E.Coli
WBPaper00056090:hpx-2(dg047)_upregulated_E.faecalis
WBPaper00056139:soil-microbiota_upregulated
WBPaper00056169:rrf-3(pk1426)_downregulated_adult
WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected
WBPaper00056330:glycine_downregulated
WBPaper00056443:sek-1(km4)_upregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
WBPaper00056471:S.aureus-4h_upregulated_N2
WBPaper00056586:kri-1(ok1251)_upregulated
WBPaper00056868:P.aeruginosa_upregulated_smallRNA
WBPaper00057154:HeatShock_upregulated_mRNA
WBPaper00057347:nhr-14(tm1473)_downreglated
WBPaper00058598:mex-1(or286)_upregulated
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058598:spn-4(tm291)_upregulated
WBPaper00058948:npr-8(ok1439)_downregulated_OP50
WBPaper00058948:npr-8(ok1439)_downregulated_PA14
WBPaper00058948:PA14_downregulated
WBPaper00058958:100mGy-irradiation-72h_upregulated
WBPaper00058969:RIS_depleted
WBPaper00059117:B.subtilis_upregulated
WBPaper00059334:sacy-1(depletion)_regulated
WBPaper00059378:lmn-1(Y59C)_downregulated
WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated
WBPaper00059421:daf-1(m40)_upregulated
WBPaper00059421:daf-3(mgDf90)_downregulated
WBPaper00059566:wdr-23(mac32)_upregulated
WBPaper00059605:mut-16(pk710)_upregulated
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00059739:hira-1(gk835598)_downregulated_L1
WBPaper00059739:hira-1(gk835598)_downregulated_L4
WBPaper00059739:hira-1(gk835598)_upregulated_adult
WBPaper00059816:crh-1(n3315)_uprgulated
WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
WBPaper00060014:set-2(tm1630)_downregulated
WBPaper00060100:SiNP_upregulated_mRNA
WBPaper00060273:isp-1(qm150)_upregulated
WBPaper00060273:vrk-1(RNAi)_downregulated
WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr
WBPaper00060434:pH4.33_vs_pH6.33_uprgulated
WBPaper00060445:nfki-1(cer1)_downregulated_L1
WBPaper00060459:bcat-1(RNAi)_upregulated
WBPaper00060479:sid-2(mj465)_upregulated
WBPaper00060526:plp-1(ok2155)_upregulated
WBPaper00060683:hlh-11(ko1)_upregulated
WBPaper00060764:swsn-1(os22ts)_upregulated
WBPaper00060811:L1_vs_adult_downregulated_neural
WBPaper00060871:M.humicola-extract_1h_regulated
WBPaper00060909:atfs-1(cmh15)_upregulated
WBPaper00061007:HB115_upregulated
WBPaper00061007:M.braciatum_upregulated
WBPaper00061007:S.aquatilis_upregulated
WBPaper00061007:X.citri_upregulated
WBPaper00061040:eat-2(ad1116)_downregulated
WBPaper00061081:E.faecalis_upregulated_N2
WBPaper00061081:skpo-1(ok1640)_upregulated_OP50
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061340:ant_arc_V
WBPaper00061340:B_F_K_Kp_U_Y
WBPaper00061340:Seam_cell
WBPaper00061340:Tail_hypodermis
WBPaper00061341:28C_48h_upregulated
WBPaper00061424:Diet_MYb120_upregulated
WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
WBPaper00061479:hda-1(ne4752)_upregulated
WBPaper00061479:hrde-1(tm1200)_upregulated
WBPaper00061479:mep-1(ne4629)_upregulated
WBPaper00061479:ubc-9(ne4833)_upregulated
WBPaper00061527:R12E2.14_75-R12E2.15
WBPaper00061995:mter-4(syb3662syb3403)_downregulated
WBPaper00062056:dpl-1(n2994)_downregulated
WBPaper00062156:jmjd-1.2(zr1010)_upregulated
WBPaper00062156:jmjd-5(zr1234)_upregulated
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062193:skn-1(RNAi)_upregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062446:nhr-8(hd117)_upregulated
WBPaper00062456:doxycycline_upregulated_N2_transcript
WBPaper00062520:qui-1(db104)_downregulated
WBPaper00062534:fat-P-80_downregulated_ech-6(RNAi)
WBPaper00062590:Aging_downregulated_neuron
WBPaper00062672:let-418(n3536)dcp-66(RNAi)_upregulated
WBPaper00062672:let-418(n3536)_upregulated
WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA
WBPaper00064005:starvation_downregulated_aptf-1(gk794)_protein
WBPaper00064005:starvation_downregulated_N2_mRNA
WBPaper00064005:starvation_downregulated_N2_protein
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064107:lin-35(n745)_downregulated
WBPaper00064156:lipl-4(overexpress)_upregulated
WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
WBPaper00064291:antimycin_upregulated
WBPaper00064306:Agaro-oligosaccharides_upregulated
WBPaper00064403:Heat-killed-E.Coli_upregulated
WBPaper00064661:lpd-3(ok2138)_upregulated
WBPaper00064727:daf-2(e1370)_upregulated
WBPaper00064728:cpl-1(W32AY35A)_upregulated
WBPaper00064841:tent-5(tm3504)_downregulated_transcript
WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
WBPaper00065029:cadmium_downregulated
WBPaper00065032:PAO1_vs_Delt.Pf4-infection_downregulated
WBPaper00065074:glna(-)_downregulated
WBPaper00065096:25C_vs_20C_downregulated
WBPaper00065096:Day10_vs_Day1_downregulated
WBPaper00065096:npr-8(ok1439)_downregulated_Day10_20C
WBPaper00065096:npr-8(ok1439)_upregulated_Day1_25C
WBPaper00065120:body-muscle-transcriptome
WBPaper00065158:AFD_depleted
WBPaper00065258:anchor-cell_enriched
WBPaper00065373:Cisplatin_downregulated_WT
WBPaper00065373:sek-1(km4)_upregulated_cisplatin
WBPaper00065560:E.coli-HB101_downregulated_F3
WBPaper00065578:gcn-1(nc40)_upregulated
WBPaper00065581:hpk-1(pk1393)_upregulated
WBPaper00065734:unc-25(e156)_downregulated
WBPaper00065746:eat-2(ad1113)_downregulated
WBPaper00065749:endu-2(tm4977)_upregulated
WBPaper00065841:82_0
WBPaper00065945:epidermis-rpoa-2(-)_downregulated_transcript
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00065993:glp-1(e2141)_downregulated
WBPaper00066004:tdp-1(csb38)_upregulated
WBPaper00066038:mip-1(how5)_upregulated
WBPaper00066093:E.coli-purE_upregulated
WBPaper00066110:Cisplatin_upregulated_diploid
WBPaper00066110:Doxorubicin_upregulated_diploid
WBPaper00066110:tetraploid_vs_diploid_upregulated
WBPaper00066232:hsf-1(RNAi)_upregulated_WT
WBPaper00025032:cluster_164
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00030839:Larval_A_Class
WBPaper00030985:Enterococcus_faecalis_upregulated
WBPaper00030985:Photorhabdus_luminescens_upregulated
WBPaper00031532:Larva_Pan_Neuronal_Depleted
WBPaper00031832:slr-2_regulated
WBPaper00032948:FedUp
WBPaper00033101:spr-5_regulated
WBPaper00035873:dpy-9_regulated
WBPaper00035873:dpy-10_regulated
WBPaper00035873:osm-8_regulated
WBPaper00036130:mir-243_up_regulated
WBPaper00036286:Pattern_G
WBPaper00038060:SUMO-1_downregulated
WBPaper00038172:aak-2overexpression_up_regulated
WBPaper00038172:crh-1null_down_regulated
WBPaper00038172:tax-6null_up_regulated
WBPaper00038304:octr-1_regulated
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
WBPaper00040821:Au-NP_regulated
WBPaper00040823:alg-1(gk214)_upregulated
WBPaper00040858:eQTL_age_regulated_developing
WBPaper00040876:mir-35_downregulated
WBPaper00041002:HF_3d_0.2mM_Up
WBPaper00041207:CE_dauer_down
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
WBPaper00042128:gei-8(ok1671)_downregulated
WBPaper00042258:DA1877_downregulated_YoungAdult
WBPaper00042331:a-SWCNTs_downregulated
WBPaper00045673:colistin_upregulated
WBPaper00045960:L1-L4-lethargus_upregulated
WBPaper00045960:L4-lethargus_upregulated
WBPaper00046083:oga-1(ok1207)_OP50_downregulated
WBPaper00046083:pmk-1(km25)_OP50_downregulated
WBPaper00046548:dafachronic-acid_downregulated
WBPaper00046853:AOBr_M.aeruginosa-batch-culture_downregulated
WBPaper00047070:N2_starvation_downregulated
WBPaper00047070:N2_UV_downregulated
WBPaper00047070:xpa-1_UV_downregulated
WBPaper00048624:hlh-25(ok1710)_upregulated
WBPaper00048989:N2_rapamycin_upregulated
WBPaper00055899:nitroguanidine_regulated
WBPaper00056330:mrps-5(RNAi)_upregulated
InteractionWBInteraction000543998
Map_info (3)
ReferenceWBPaper00028754
WBPaper00031588
WBPaper00050709
WBPaper00062388
WBPaper00064105
Remarkground-like gene, contains ground-like domain, hedgehog-relatedPaper_evidenceWBPaper00003717
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene