| WBGene00000802 | SMap | S_parent | Sequence | Y38A10A |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | crt-1 |
| | | Sequence_name | Y38A10A.5 |
| | | Molecular_name | Y38A10A.5 |
| | | | Y38A10A.5.1 |
| | | | CE21562 |
| | | Other_name | CELE_Y38A10A.5 | Accession_evidence | NDB | BX284605 |
| | | Public_name | crt-1 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | crt |
| | Allele (34) |
| | Legacy_information | [C.elegansII] NMK. Encodes predicted 395 aa calreticulin(61% identity to mouse calreticulin). [Smith 1992] |
| | Strain | WBStrain00023525 |
| | | WBStrain00031729 |
| | | WBStrain00040781 |
| | | WBStrain00040782 |
| | | WBStrain00040783 |
| | | WBStrain00040784 |
| | RNASeq_FPKM (74) |
| | GO_annotation (31) |
| | Ortholog (47) |
| | Paralog | WBGene00000567 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | crt-1 encodes an ortholog of calreticulin (a calcium-binding molecularchaperone of the endoplasmic reticulum); crt-1 is dispensable forviability, but required for normal sperm development, male matingefficiency, some forms of necrotic cell death, and hermaphrodite fertilityat high temperatures (which may reflect a stress response); crt-1expression is induced by stress; CRT-1 protein binds Ca(2+) and cansuppress heat-induced protein aggregation in vitro; crt-1(bz29) andcrt-1(bz30) mutants suppress necrotic cell death induced either bymec-4(d) or by a constitutively activated Gas subunit; crt-1(bz29);crt-1's suppression of necrosis is itself partly reversed by thapsigargin,which enhances calcium release from the endoplasmic reticulum;crt-1(bz30), and crt-1(jh101) mutants grow more slowly, and have havereduced broods at 25 deg. C.; crt-1(jh101) mutants are slightly shorterthan normal and have defective sperm; CRT-1 and ITR-1 serve partlyredundant functions in vivo, since crt-1;itr-1(sa73) are highly infertileand slow-growing with greatly slowed defecation; a number of proteins,notably HSP-3/4 and PDI-2/3, are over-expressed in crt-1(jh101) mutantsand crt-1(jh101);cnx-1(nr2009) double mutants. | Paper_evidence | WBPaper00004858 |
| | | | | | WBPaper00004880 |
| | | | | | WBPaper00027024 |
| | | | | Curator_confirmed | WBPerson567 |
| | | | | Date_last_updated | 21 Aug 2006 00:00:00 |
| | | Automated_description | Enables calcium ion binding activity. Involved in several processes, including IRE1-mediated unfolded protein response; determination of adult lifespan; and hemidesmosome assembly. Located in cytoplasm. Expressed in several structures, including coelomocyte; excretory system; intestine; pharynx; and sperm. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in several diseases, including endocrine gland cancer (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Is an ortholog of human CALR (calreticulin). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00053621 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 04 Mar 2019 00:00:00 |
| | Potential_model (22) |
| Models_disease_asserted | WBDOannot00000639 |
| Molecular_info | Corresponding_CDS | Y38A10A.5 |
| | Corresponding_transcript | Y38A10A.5.1 |
| | Other_sequence (306) |
| | Associated_feature (15) |
| Experimental_info | RNAi_result (25) |
| | Expr_pattern (12) |
| | Drives_construct | WBCnstr00000682 |
| | | WBCnstr00010817 |
| | | WBCnstr00037266 |
| | Construct_product | WBCnstr00006884 |
| | | WBCnstr00037266 |
| | Regulate_expr_cluster | WBPaper00064957:crt-1(jvp1)_downregulated |
| | | WBPaper00064957:crt-1(jvp1)_upregulated |
| | | WBPaper00064957:crt-1(knu358)_downregulated |
| | | WBPaper00064957:crt-1(knu358)_upregulated |
| | Antibody | WBAntibody00000408 |
| | Microarray_results (24) |
| | Expression_cluster | WBPaper00024704:Soluble_protein |
| | | WBPaper00026640:Development_Group_O |
| | | WBPaper00026640:embryo-to-L1_upregulated |
| | | WBPaper00032528:L3_enriched |
| | | WBPaper00035073:mitochondria_protein |
| | | WBPaper00035963:S.aureus_4h_downregulated |
| | | WBPaper00035963:S.aureus_8h_downregulated |
| | | WBPaper00035963:S.aureus_24h_downregulated |
| | | WBPaper00037047:aging_accelerated_insoluble_protein |
| | | WBPaper00037047:insoluble_protein |
| | | WBPaper00037109:cyclophilin-inhibitor_regulated |
| | | WBPaper00038289:oocyte_protein |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00040965:lipid-droplet_associated_protein |
| | | WBPaper00041257:irradiation_downregulated |
| | | WBPaper00041506:C_enriched |
| | | WBPaper00043951:insoluble_protein_day16_N2 |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044746:aging_downregulated_Day5 |
| | | WBPaper00044746:aging_downregulated_HeatShock |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Spermatogenic |
| | | WBPaper00045774:clk-1_downregulated |
| | | WBPaper00045971:tunicamycin_upregulated_RtcB(null) |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00048910:mRNA-interacting_protein |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi) |
| | | WBPaper00049942:HeatShock_upregulated_hsf-1(+) |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050698:DEP-1_interacting |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_nucleus_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053289:DREAM-target |
| | | WBPaper00053295:lin-22(ot269)_downregulated |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053388:dauer_regulated_Cluster3 |
| | | WBPaper00053599:mitosis_vs_meiosis_downregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated |
| | | WBPaper00053606:N2_vs_elt-2(ca15)_upregulated |
| | | WBPaper00054996:activated_sperm_CE |
| | | WBPaper00054996:membranous_oraganelle_CE |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_upregulated |
| | | WBPaper00055648:male-vas-deferens_expressed |
| | | WBPaper00055897:heat-shock_upregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_downregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056073:NHR-86_interacting_promoter |
| | | WBPaper00056139:soil-microbiota_upregulated |
| | | WBPaper00056161:male_enriched_siRNA |
| | | WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056809:smn-1(ok355)_downregulated |
| | | WBPaper00056900:PID-3_interacting |
| | | WBPaper00057041:spc-1(cas971)_upregulated |
| | | WBPaper00057041:unc-70(cas983)_upregulated |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058691:cfp-1(tm6369)_downregulated |
| | | WBPaper00058691:sin-3(tm1276)_downregulated |
| | | WBPaper00059174:MEG-3_interacting |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA |
| | | WBPaper00059373:stt-3(RNAi)_upregulated |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059604:fluvastatin_downregulated_dlk-1(km12) |
| | | WBPaper00059604:fluvastatin_downregulated_N2 |
| | | WBPaper00060084:DVE-1_interacting_protein_cco-1(RNAi) |
| | | WBPaper00060224:atf-6(ok551)_downregulated |
| | | WBPaper00060683:hlh-11(ko1)_upregulated |
| | | WBPaper00060683:hlh-11(overexpression)_downregulated |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:Body_wall_muscle |
| | | WBPaper00061340:Coelomocyte |
| | | WBPaper00061340:g1A |
| | | WBPaper00061340:g1A_g1P |
| | | WBPaper00061340:g1P |
| | | WBPaper00061340:Pharyngeal_marginal_cell |
| | | WBPaper00061377:MYRF-1_interacting |
| | | WBPaper00061377:MYRF-2_interacting |
| | | WBPaper00061377:PAN-1_interacting |
| | | WBPaper00061439:unc-30(ok613)_upregulated |
| | | WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection |
| | | WBPaper00061478:SUMO-conjugated_protein |
| | | WBPaper00061527:uggt-1_21889-tag-320_20312 |
| | | WBPaper00061651:AIZ_enriched |
| | | WBPaper00061651:Coelomocyte_enriched |
| | | WBPaper00061651:Distal_tip_cell_enriched |
| | | WBPaper00061651:Excretory_gland_cell_enriched |
| | | WBPaper00061651:IL2_DV_enriched |
| | | WBPaper00061651:MC_enriched |
| | | WBPaper00061651:SIA_enriched |
| | | WBPaper00061651:Spermatheca_enriched |
| | | WBPaper00061651:VB01_enriched |
| | | WBPaper00061651:VB02_enriched |
| | | WBPaper00061651:VB_enriched |
| | | WBPaper00061818:AFD_enriched_protein |
| | | WBPaper00062056:lin-35(n745)_downregulated |
| | | WBPaper00062143:PQN-59_interacting |
| | | WBPaper00062193:skn-1(RNAi)_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062554:MAGU-2_interacting |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064005:starvation_upregulated_aptf-1(gk794)_mRNA |
| | | WBPaper00064005:starvation_upregulated_N2_mRNA |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064122:vulva_transcriptome |
| | | WBPaper00064315:mes-4(bn73)_upregulated_PGCs |
| | | WBPaper00064403:Heat-killed-E.Coli_upregulated |
| | | WBPaper00064532:pals-25(icb98)_upregulated |
| | | WBPaper00064933:E.coli-binding_secret_protein |
| | | WBPaper00064952:Day10_vs_L4_downregulated_20C |
| | | WBPaper00064952:Day10_vs_L4_downregulated_25C |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065149:lin-52(n771)_downregulated |
| | | WBPaper00065373:Cisplatin_downregulated_WT |
| | | WBPaper00065373:sek-1(km4)_downregulated_cisplatin |
| | | WBPaper00065373:sek-1(km4)_downregulated_Ref |
| | | WBPaper00065835:Day11_vs_Day1_upregulated |
| | | WBPaper00065841:89_0 |
| | | WBPaper00065975:P-body_vs_oocyte_depleted |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | cgc4386_cluster_3_4 |
| | | cgc4489_group_20 |
| | | WBPaper00005124:cholesterol_10-9M_regulated |
| | | WBPaper00005124:estrogen_10-5M_regulated |
| | | WBPaper00005124:progesterone_10-7M_regulated |
| | | WBPaper00006465:II_ethanol_late_induction |
| | | WBPaper00025032:cluster_71 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00030985:Enterococcus_faecalis_upregulated |
| | | WBPaper00030985:Photorhabdus_luminescens_upregulated |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_1 |
| | | WBPaper00032948:FedUp |
| | | WBPaper00036286:Pattern_G |
| | | WBPaper00037695:WC_5-day |
| | | WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated |
| | | WBPaper00040426:CYD-1_CDK-4_downregulated |
| | | WBPaper00040426:CYE-1_CDK-2AF_downregulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041906:I-3690_vs_OP50_10d |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041960:N2_fasting_upregulated_9hto12h |
| | | WBPaper00041960:N2_fasting_upregulated_anytime |
| | | WBPaper00045015:nhr-25(RNAi)_upregulated |
| | | WBPaper00045263:isp-1(qm150)_downregulated |
| | | WBPaper00045263:nuo-6(qm200)_downregulated |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc5767]:cluster_43 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(23_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | | [cgc6390]:Cluster_C |
| | Interaction (116) |
| | WBProcess | WBbiopr:00000046 |
| | | WBbiopr:00000079 |
| Map_info (4) |
| Reference (72) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
