| WBGene00022856 | SMap | S_parent | Sequence | ZK1127 |
|---|
| Identity | Version | 2 |
| | Name | CGC_name | cth-2 | Person_evidence | WBPerson1711 |
| | | Sequence_name | ZK1127.10 |
| | | Molecular_name | ZK1127.10 |
| | | | ZK1127.10.1 |
| | | | CE07648 |
| | | Other_name | CELE_ZK1127.10 | Accession_evidence | NDB | BX284602 |
| | | Public_name | cth-2 |
| | DB_info | Database (13) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 28 May 2004 13:31:06 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 |
| | | | 2 | 10 Sep 2008 16:37:04 | WBPerson2970 | Name_change | CGC_name | cth-2 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | cth |
| | Allele (15) |
| | Strain | WBStrain00007972 |
| | RNASeq_FPKM (74) |
| | GO_annotation (20) |
| | Ortholog (41) |
| | Paralog | WBGene00007533 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00009048 | Caenorhabditis elegans | From_analysis | Inparanoid_8 |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | cth-2 encodes a putative cystathionine gamma-lyase; CTH-2 is orthologous to human CTH (OMIM:607657, mutated in cystathioninuria), extremely similar to its paralog CTH-1, and also paralogous to CBL-1; either CTH-2, or CTH-1, or both proteins weakly inhibitDHC-1 in vivo; CTH-2 is expressed in both larval and adult hypodermis, anal depressor muscle, and body wall muscle, as well as in adult vulval muscle and reproductive system; CTH-2 binds SMN-1 in yeast two-hybrid assays. | Paper_evidence | WBPaper00006525 |
| | | | | | WBPaper00028478 |
| | | | | | WBPaper00030897 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson1823 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 15 Sep 2011 00:00:00 |
| | | Automated_description | Predicted to enable cystathionine gamma-lyase activity and pyridoxal phosphate binding activity. Predicted to be involved in cysteine biosynthetic process via cystathionine and transsulfuration. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in cystathioninuria. Is an ortholog of human CTH (cystathionine gamma-lyase). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:9252 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2501) |
| | | DOID:0090142 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2501) |
| Molecular_info | Corresponding_CDS | ZK1127.10 |
| | Corresponding_transcript | ZK1127.10.1 |
| | Other_sequence (100) |
| | Associated_feature | WBsf650204 |
| | | WBsf655366 |
| | | WBsf655367 |
| | | WBsf665670 |
| | | WBsf988344 |
| | | WBsf1012482 |
| | | WBsf223280 |
| | | WBsf223281 |
| Experimental_info | RNAi_result (15) |
| | Expr_pattern | Chronogram527 |
| | | Expr7188 |
| | | Expr9561 |
| | | Expr1017288 |
| | | Expr1040112 |
| | | Expr1162551 |
| | | Expr2010574 |
| | | Expr2028814 |
| | Drives_construct | WBCnstr00002589 |
| | | WBCnstr00023917 |
| | | WBCnstr00040868 |
| | Construct_product | WBCnstr00014126 |
| | | WBCnstr00023917 |
| | | WBCnstr00040868 |
| | | WBCnstr00040869 |
| | | WBCnstr00040870 |
| | | WBCnstr00040871 |
| | | WBCnstr00040872 |
| | Microarray_results (20) |
| | Expression_cluster | WBPaper00024704:Soluble_protein |
| | | WBPaper00029359_1183 |
| | | WBPaper00029359_1280 |
| | | WBPaper00029359_1310 |
| | | WBPaper00029359_1362 |
| | | WBPaper00029359_1364 |
| | | WBPaper00029359_1444 |
| | | WBPaper00029359_1504 |
| | | WBPaper00029359_1578 |
| | | WBPaper00029359_1604 |
| | | WBPaper00029359_1636 |
| | | WBPaper00032031:DConiospora_upregulated_cDNA_12h |
| | | WBPaper00032528:L3_enriched |
| | | WBPaper00033065:clk-1(qm30)_upregulated |
| | | WBPaper00035073:mitochondria_protein |
| | | WBPaper00035269:cde-1_regulated |
| | | WBPaper00035926:A.hydrophila_regulated |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:germline-precursors_embryo_enriched |
| | | WBPaper00037950:germline-precursors_embryo_SelectivelyEnriched |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038168:lin-15B(n744)_downregulated |
| | | WBPaper00038213:E.coli(LF82)_72h_downregulated |
| | | WBPaper00038289:oocyte_protein |
| | | WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq |
| | | WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray |
| | | WBPaper00040134:nhr-49(RNAi)_regulated_protein |
| | | WBPaper00042215:wdr-23(tm1817)_upregulated |
| | | WBPaper00044128:DietaryRestriction_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044743:wdr-23_neuron_upregulated |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated |
| | | WBPaper00045217:prg-1_progressively_regulated |
| | | WBPaper00045521:Spermatogenic |
| | | WBPaper00045571:germline-ablation_upregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_downregulated_protein |
| | | WBPaper00046795:starvation_downregulated |
| | | WBPaper00048910:mRNA-interacting_protein |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049018:ham-3(RNAi)_downregulated |
| | | WBPaper00049545:cco-1(RNAi)_downregulated |
| | | WBPaper00049545:jmjd-3.1(+)_downregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated |
| | | WBPaper00049905:Age_variant_expression |
| | | WBPaper00049942:hsf-1(RNAi)_downregulated |
| | | WBPaper00049954:BPA_downregulated |
| | | WBPaper00050332:juglone_upregulated |
| | | WBPaper00050332:skn-1(RNAi)_downregulated |
| | | WBPaper00050344:PLM-neuron_enriched |
| | | WBPaper00050370:dpy-21(e428)_L3_upregulated |
| | | WBPaper00050412:cco-1(RNAi)_downregulated_N2 |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:intestine_enriched |
| | | WBPaper00051245:body-wall-muscle_cytoplasm_expressed |
| | | WBPaper00051245:body-wall-muscle_nucleus_expressed |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_nucleus_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051245:intestine_nucleus_expressed |
| | | WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed |
| | | WBPaper00051265:F4_hrde-1(tm1200)_upregulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053302:alovudine_24h_regulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053388:dauer_regulated_Cluster5 |
| | | WBPaper00053599:female_vs_male_downregulated |
| | | WBPaper00053615:SMO-1_target |
| | | WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated |
| | | WBPaper00053814:25C_upregulated_PY79 |
| | | WBPaper00054189:P.aeruginosa_regulated_protein |
| | | WBPaper00054192:cold-shock_downregulated |
| | | WBPaper00055049:S.gordonii_upregulated |
| | | WBPaper00055060:flr-1(RNAi)_downregulated |
| | | WBPaper00055354:eat-2(ad1116)_downregulated |
| | | WBPaper00055354:Psora-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Metformin_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055626:pry-1(mu38)_downregulated |
| | | WBPaper00056039:efa-6(tm3124)_upregulated |
| | | WBPaper00056139:soil-microbiota_downregulated |
| | | WBPaper00056161:male_enriched_siRNA |
| | | WBPaper00056443:DietaryRestriction_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00056471:S.aureus-4h_downregulated_N2 |
| | | WBPaper00056826:SGP_biased |
| | | WBPaper00057006:DietaryRestriction_downregulated |
| | | WBPaper00057041:spc-1(cas971)_upregulated |
| | | WBPaper00057041:unc-70(cas983)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058969:RIS_depleted |
| | | WBPaper00059027:neuron-synapses_enriched |
| | | WBPaper00059191:hsp-16.2p-LIN-29_upregulated |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_protein |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059440:LAG-1_activated_4hr-auxin |
| | | WBPaper00059566:wdr-23(mac32)_upregulated |
| | | WBPaper00059605:MUT-16_interacting |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059739:hira-1(gk835598)_downregulated_adult |
| | | WBPaper00059987:Wounding_downregulated |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060014:set-2(zr2012)_downregulated |
| | | WBPaper00060084:cco-1(RNAi)_downregulated_N2 |
| | | WBPaper00060278:atp-2(RNAi)_upregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_N2 |
| | | WBPaper00060434:pH4.33_vs_pH6.33_uprgulated |
| | | WBPaper00060811:L1_vs_adult_downregulated_neural |
| | | WBPaper00060911:prx-5(RNAi)_downregulated_mRNA |
| | | WBPaper00061045:Y56A3A.22(cck200)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:Rectal_cell |
| | | WBPaper00061341:28C_48h_downregulated |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061479:mep-1(ne4629)_upregulated |
| | | WBPaper00061527:mup-2-unc-87_284 |
| | | WBPaper00061651:Gonadal_sheath_cell_enriched |
| | | WBPaper00061818:AFD_enriched_protein |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062440:crh-1(n3315)_upregulated |
| | | WBPaper00062440:crh-1(syb385)_upregulated |
| | | WBPaper00062456:doxycycline_upregulated_CB4856_protein |
| | | WBPaper00062554:MAGU-2_interacting |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00063976:micu-1(bon20)_upregulated |
| | | WBPaper00064005:starvation_downregulated_aptf-1(gk794)_protein |
| | | WBPaper00064005:starvation_downregulated_N2_protein |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064130:Beta-Amyloid_upregulated_protein |
| | | WBPaper00064163:ZNFX-1_interacting_young-adult |
| | | WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated |
| | | WBPaper00064502:nhr-23(kry61);spe-44(fx110)_downregulated |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064727:daf-2(e1370)_upregulated |
| | | WBPaper00064735:bet-1(uth41)_vs_N2_upregulated |
| | | WBPaper00064933:bcf-1(ylf1)_downregulated_transcript |
| | | WBPaper00065086:JU1400_N.ausubeli_regulated |
| | | WBPaper00065086:JU1400_N.ferruginous_regulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065272:dhgd-1(tm6671)_downregulated |
| | | WBPaper00065373:Cisplatin_downregulated_WT |
| | | WBPaper00065373:sek-1(km4)_downregulated_cisplatin |
| | | WBPaper00065373:sek-1(km4)_downregulated_Ref |
| | | WBPaper00065746:tmc-1(rg1003)_upregulated |
| | | WBPaper00065841:26_2 |
| | | WBPaper00065975:P-body_vs_oocyte_depleted |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | WBPaper00066085:hda-3(ok1991)_upregulated |
| | | WBPaper00066085:sin-3(syb2172)_upregulated |
| | | WBPaper00066085:sin-3(tm1276)_upregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14 |
| | | cgc4386_cluster_1_5 |
| | | cgc4489_group_24 |
| | | WBPaper00024671:AFD_vs_AWB_downregulated |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00027342:alpha-Synuclein(WT)_upregulated |
| | | WBPaper00028482:PA14_upregulated |
| | | WBPaper00031003:24hr_muscle_enriched |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031003:total_muscle_enriched |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Depleted |
| | | WBPaper00032062:age_regulated_genes |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_6 |
| | | WBPaper00035084:L3_enriched_AIN-2_IP |
| | | WBPaper00035873:dpy-9_regulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00035873:osm-7_regulated |
| | | WBPaper00035873:osm-8_regulated |
| | | WBPaper00035873:osm-11_regulated |
| | | WBPaper00035873:osmotically_regulated |
| | | WBPaper00036123:Fluoranthene_regulated |
| | | WBPaper00036286:Pattern_I |
| | | WBPaper00037695:WC_5-day |
| | | WBPaper00038231:Cry5B_1.5-fold_downregulated |
| | | WBPaper00039835:ifg-1_upregulated |
| | | WBPaper00040184:hcf-1down_sir-2.1down_daf-2nc |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040985:AIN-2_asynchronous_intestine |
| | | WBPaper00040985:AIN-2_L4_intestine |
| | | WBPaper00041174:environmental |
| | | WBPaper00041174:environmental_prime |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h |
| | | WBPaper00042548:miRISC_enriched |
| | | WBPaper00045263:0.1mM-paraquat_downregulated |
| | | WBPaper00045960:L1-L4-lethargus_downregulated |
| | | WBPaper00045960:L4-lethargus_downregulated |
| | | WBPaper00047070:N2_starvation_upregulated |
| | | WBPaper00048624:hlh-25(ok1710)_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_upregulated |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_ET |
| | | [cgc5767]:expression_class_ET_max(23_min) |
| | | [cgc5767]:expression_class_E_pi(23_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | | [cgc5767]:expression_class_MET |
| | | [cgc5976]:class_2 |
| | | [cgc6390]:mixed_spermatogenesis-somatic |
| | Interaction (91) |
| Map_info | Map | II | Position | 0.361481 | Error | 0.004775 |
| | Positive | Positive_clone | ZK1127 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference | WBPaper00028478 |
| | WBPaper00038444 |
| | WBPaper00038491 |
| | WBPaper00040135 |
| | WBPaper00040475 |
| | WBPaper00044324 |
| | WBPaper00049828 |
| | WBPaper00055090 |
| | WBPaper00056452 |
| | WBPaper00062518 |
| | WBPaper00063976 |
| | WBPaper00064989 |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
