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WormBase Tree Display for Gene: WBGene00004980

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Name Class

WBGene00004980SMapS_parentSequenceB0464
IdentityVersion1
NameCGC_namespk-1Person_evidenceWBPerson1315
Sequence_nameB0464.5
Molecular_name (13)
Other_namesrk-1
rsk-1Paper_evidenceWBPaper00003988
CELE_B0464.5Accession_evidenceNDBBX284603
Public_namespk-1
DB_infoDatabase (14)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:37WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classspk
Allele (80)
StrainWBStrain00035941
RNASeq_FPKM (74)
GO_annotation (25)
Ortholog (51)
ParalogWBGene00001121Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00002178Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00002187Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00002188Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00003048Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00003401Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00003402Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00004055Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00004056Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00004057Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00004859Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00015478Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00019665Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00013091Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00008200Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00013705Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00007977Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00017672Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00013701Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00017277Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00009921Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
Structured_descriptionConcise_descriptionspk-1 encodes a serine/threonine kinase orthologous to the highly conserved serine/arginine-rich protein kinases (SRPKs) that phosphorylate SR proteins, essential components of the pre-mRNA splicing machinery; SPK-1, required for embryogenesis and germline development, can directly bind and phosphorylate RSP-3 (CeSF2/ASF), an SR splicing factor homolog; SPK-1 is expressed predominantly in the adult germline; SPK-1 is homologous to human RSK2, which when mutated leads to Coffin-Lowry syndrome (OMIM:303600).Paper_evidenceWBPaper00004103
WBPaper00004476
Curator_confirmedWBPerson1843
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionEnables protein serine/threonine kinase activity. Involved in embryo development. Predicted to be located in cytoplasm and nucleus. Expressed in several structures, including gonad and tail. Is an ortholog of human SRPK1 (SRSF protein kinase 1); SRPK2 (SRSF protein kinase 2); and SRPK3 (SRSF protein kinase 3).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDS (4)
Corresponding_CDS_historyB0464.5a:wp123
B0464.5c:wp119
Corresponding_transcriptB0464.5a.1
B0464.5a.2
B0464.5b.1
B0464.5c.1
B0464.5d.1
Other_sequence (83)
Associated_feature (20)
Experimental_infoRNAi_result (17)
Expr_patternChronogram621
Expr439
Expr1128
Expr5076
Expr1028333
Expr1032478
Expr1143250
Expr2016060
Expr2034296
Drives_constructWBCnstr00004059
WBCnstr00035294
Construct_productWBCnstr00035294
Microarray_results (50)
Expression_clusterWBPaper00029359_1280
WBPaper00029359_1310
WBPaper00029359_1362
WBPaper00029359_1364
WBPaper00029359_1444
WBPaper00029359_1504
WBPaper00029359_1578
WBPaper00029359_1587
WBPaper00029359_1604
WBPaper00031040:TGF-beta_adult_downregulated
WBPaper00032528:L3_enriched
WBPaper00033065:cyc-1(RNAi)_downregulated
WBPaper00033065:cyc-1(RNAi)_upregulated
WBPaper00036375:enriched_in_PVD_OLL
WBPaper00037047:insoluble_protein
WBPaper00037950:bodywall-muscle_L2-larva_expressed
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00038118:aak-2(gt33)_upregulated
WBPaper00040221:DAF-12_target_ALF4
WBPaper00044426:rotenone_24h_downregulated
WBPaper00044656:tatn-1(qd182)_downregulated
WBPaper00044736:flat_dev_expression
WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
WBPaper00045420:fertilization_downregulated_transcript
WBPaper00045521:Gender_Neutral
WBPaper00045774:clk-1_downregulated
WBPaper00048810:CoQ-deficiency_downregulated
WBPaper00048910:mRNA-interacting_protein
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_expressed
WBPaper00049545:cco-1(RNAi)_upregulated
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
WBPaper00050015:ifg-1(RNAi)_upregulated
WBPaper00050234:lin-28(RNAi)_upregulated
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:body-muscle_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00050990:pharynx_expressed
WBPaper00050990:seam_expressed
WBPaper00051039:germline_enriched
WBPaper00051245:body-wall-muscle_cytoplasm_expressed
WBPaper00051245:epidermis_cytoplasm_expressed
WBPaper00051245:intestine_cytoplasm_expressed
WBPaper00051558:aging_regulated
WBPaper00052884:emb-4(hc60)_downregulated
WBPaper00053184:sma-4(rax3)_downregulated
WBPaper00053302:zidovudine_24h_regulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053713:Pheromone-induced_postdauer_vs_control_upregulated
WBPaper00055226:ADR-2_target_N2
WBPaper00055334:DLC-1_interacting
WBPaper00055648:germline_expressed
WBPaper00055862:antimycin_damt-1(gk961032)_regulated
WBPaper00055971:nhl-2(ok818)_25C_upregulated
WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
WBPaper00056275:P.aeruginosa_downregulated
WBPaper00056275:P.aeruginosa_downregulated_pmk-1(km25)_dependent
WBPaper00056443:sek-1(km4)_downregulated
WBPaper00056471:S.aureus-4h_upregulated_N2
WBPaper00059471:EGL-43_interacting
WBPaper00059754:E.faecalis_OG1RF_upregulated
WBPaper00059763:neuron_expressed
WBPaper00060014:set-2(tm1630)_downregulated
WBPaper00060100:SiNP_upregulated_mRNA
WBPaper00061199:GYF-1_interacting
WBPaper00061340:AIA
WBPaper00061527:dld-1-skn-1_16701
WBPaper00061527:gpb-1_3783-C48A7.2_22459
WBPaper00061651:DB_enriched
WBPaper00062325:muscle_enriched_coding-RNA
WBPaper00062354:H.zoospora_6h_regulated
WBPaper00064005:starvation_upregulated_N2_mRNA
WBPaper00064055:trl-1(cas1077)_upregulated_non-starved
WBPaper00064071:NHR-49_interacting
WBPaper00064122:vulva_transcriptome
WBPaper00064716:paraquat_upregulated
WBPaper00064789:Day12_vs_Day1_downregulated_neuron
WBPaper00065086:JU1400_N.ausubeli_regulated
WBPaper00065086:JU1400_N.ferruginous_regulated
WBPaper00065120:body-muscle-transcriptome
WBPaper00065373:Cisplatin_upregulated_WT
WBPaper00065373:sek-1(km4)_upregulated_cisplatin
cgc4386_cluster_6_3
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00030985:Erwinia_carotovora_upregulated
WBPaper00030985:Photorhabdus_luminescens_upregulated
WBPaper00031252:AIN-1_IP_enriched
WBPaper00031252:AIN-2_IP_enriched
WBPaper00031832:slr-2_regulated
WBPaper00040210:Chlorpyrifos_24C_regulated
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
WBPaper00040821:Au-NP_regulated
WBPaper00040823:alg-1(gk214)_downregulated
WBPaper00040963:TA300_down
WBPaper00041002:HQ_3d_0.2mM_Down
WBPaper00041002:HQ_3d_2.0mM_Down
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
WBPaper00048989:N2_allantoin_downregulated
WBPaper00053236:Starvation_regulated_GR1307
WBPaper00053236:Starvation_regulated_N2
WBPaper00057098:SiO2-nanoparticles_upregulated
[cgc5767]:expression_class_E
[cgc5767]:expression_class_E_pi(23_min)
[cgc5767]:expression_class_SE
[cgc5767]:expression_class_SE_pi(23_min)
Interaction (131)
WBProcessWBbiopr:00000014
Map_infoMapIIIPosition0.536942Error0.008194
PositivePositive_cloneB0464Inferred_automaticallyFrom sequence, transcript, pseudogene data
T01H8
Mapping_dataMulti_point5000
Pseudo_map_position
Reference (19)
RemarkThe srk-1 gene was merged into this gene following advice by Jonathan Hodgkin. srk-1 was connected to different sequences which may have been in error and these sequence connections have been removed from the merged gene. krb 27/02/02
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene