WormBase Tree Display for Gene: WBGene00002187
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| WBGene00002187 | Evidence | Paper_evidence | WBPaper00005583 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | T07A9 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | kgb-1 | Person_evidence | WBPerson57 | |||||
| Sequence_name | T07A9.3 | ||||||||
| Molecular_name | T07A9.3 | ||||||||
| T07A9.3.1 | |||||||||
| CE29466 | |||||||||
| T07A9.3.2 | |||||||||
| T07A9.3.3 | |||||||||
| Other_name | CELE_T07A9.3 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | kgb-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | kgb | ||||||||
| Allele (75) | |||||||||
| Strain | WBStrain00023465 | ||||||||
| WBStrain00023468 | |||||||||
| WBStrain00024039 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (71) | |||||||||
| Ortholog (46) | |||||||||
| Paralog (21) | |||||||||
| Structured_description | Concise_description | kgb-1 encodes a serine/threonine kinase that is a member of the JNK (Jun-N-terminal kinase) subfamily of MAP (mitogen-activated protein)kinases; loss of kgb-1 activity results in temperature-sensitive sterility in hermaphrodites and males; in hermaphrodites, this sterility is associated with disorganized gonads and endomitotic oocytes that have likely failed to undergo oocyte maturation; in kgb-1 mutant males, sperm is present, but is non-functional; KGB-1 interacts in vitro with all four C. elegans germline helicases, GLH-1, -2, -3, and -4, that localize to P granules in vivo; Northern analyses indicate that kgb-1 mRNA is present in both somatic and germline tissues. | Paper_evidence | WBPaper00005583 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 19 Apr 2006 00:00:00 | ||||||||
| Automated_description | Enables DEAD/H-box RNA helicase binding activity; JUN kinase activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including gamete generation; response to inorganic substance; and response to toxic substance. Located in cytoplasm. Expressed in several structures, including excretory cell; germ line; gonad; nerve ring; and tail ganglion. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | T07A9.3 | |||||||
| Corresponding_transcript | T07A9.3.1 | ||||||||
| T07A9.3.2 | |||||||||
| T07A9.3.3 | |||||||||
| Other_sequence (45) | |||||||||
| Associated_feature | WBsf667712 | ||||||||
| WBsf667713 | |||||||||
| WBsf667714 | |||||||||
| WBsf229683 | |||||||||
| WBsf229684 | |||||||||
| WBsf229685 | |||||||||
| Experimental_info | RNAi_result (24) | ||||||||
| Expr_pattern | Expr7816 | ||||||||
| Expr12103 | |||||||||
| Expr13915 | |||||||||
| Expr13916 | |||||||||
| Expr13962 | |||||||||
| Expr1022674 | |||||||||
| Expr1031281 | |||||||||
| Expr1156314 | |||||||||
| Expr2012924 | |||||||||
| Expr2031158 | |||||||||
| Drives_construct | WBCnstr00020193 | ||||||||
| WBCnstr00020194 | |||||||||
| WBCnstr00036401 | |||||||||
| WBCnstr00040360 | |||||||||
| WBCnstr00040480 | |||||||||
| Construct_product | WBCnstr00020194 | ||||||||
| WBCnstr00036401 | |||||||||
| WBCnstr00040360 | |||||||||
| WBCnstr00040480 | |||||||||
| Regulate_expr_cluster | WBPaper00050448:KGB-1-induced | ||||||||
| Antibody | WBAntibody00000996 | ||||||||
| WBAntibody00000997 | |||||||||
| WBAntibody00001293 | |||||||||
| WBAntibody00001469 | |||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (154) | |||||||||
| Interaction (109) | |||||||||
| WBProcess | WBbiopr:00000096 | ||||||||
| Map_info | Map | IV | Position | -26.1142 | Error | 0.02485 | |||
| Positive | Positive_clone | T07A9 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4370 | |||||||
| 4454 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (82) | |||||||||
| Picture | WBPicture0000013081 | ||||||||
| Remark | Protein interacts with GLH (germ line helicase) proteins. Deletion allele um3, 206 aa removed. Homozygotes fertile at 20C, 40% sterile at 25C, 100% sterile at 26C. Abnormal oogenesis (Emo). Sperm present but males infertile. RNAi some sterility" [CGC_data_submission][030325 ck1] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
