WormBase Tree Display for Gene: WBGene00002178
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| WBGene00002178 | SMap | S_parent | Sequence | B0478 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | jnk-1 | Person_evidence | WBPerson1122 | |||||
| Sequence_name | B0478.1 | ||||||||
| Molecular_name | B0478.1a | ||||||||
| B0478.1a.1 | |||||||||
| CE27574 | |||||||||
| B0478.1b | |||||||||
| CE30123 | |||||||||
| B0478.1b.1 | |||||||||
| B0478.1c | |||||||||
| Other_name | sak-1 | ||||||||
| CELE_B0478.1 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | jnk-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | jnk | ||||||||
| Allele (51) | |||||||||
| Strain | WBStrain00035480 | ||||||||
| WBStrain00054748 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (45) | |||||||||
| Ortholog (61) | |||||||||
| Paralog (21) | |||||||||
| Structured_description | Concise_description | jnk-1 encodes a serine/threonine kinase that is the sole C. elegans member of the c-Jun N-terminal kinase (JNK) subgroup of mitogen-activated protein (MAP) kinases; jnk-1 is required for normal coordinated locomotion as well as for normal adult lifespan and response to heat and oxidative stress; JNK-1 exhibits kinase activity in vitro that is dependent upon activation by the JKK-1/MAPKK; in addition, JKK-1-dependent JNK-1 phosphorylation is required for JNK-1-mediated lifespan extension, as is DAF-16, with which JNK-1 physically interacts and phosphorylates and whose nuclear translocation is under JNK-1 control; a JNK-1::GFP translational fusion protein is expressed in nearly all neuronal cell bodies and processes, including the nerve ring, head and tail ganglions, and the dorsal and ventral nerve cords, at all stages of development. | Paper_evidence | WBPaper00003607 | |||||
| WBPaper00025132 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 06 May 2009 00:00:00 | ||||||||
| Automated_description | Enables JUN kinase activity and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including determination of adult lifespan; negative regulation of cellular response to manganese ion; and vesicle transport along actin filament. Located in several cellular components, including axon; neuronal cell body; and nucleus. Expressed in AIYL; AIYR; and neurons. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; abdominal aortic aneurysm; carcinoma (multiple); and intestinal benign neoplasm (multiple). Is an ortholog of human MAPK10 (mitogen-activated protein kinase 10); MAPK8 (mitogen-activated protein kinase 8); and MAPK9 (mitogen-activated protein kinase 9). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (11) | ||||||||
| Molecular_info | Corresponding_CDS | B0478.1a | |||||||
| B0478.1b | |||||||||
| Corresponding_transcript | B0478.1c | ||||||||
| B0478.1a.1 | |||||||||
| B0478.1b.1 | |||||||||
| Other_sequence (48) | |||||||||
| Associated_feature (13) | |||||||||
| Experimental_info | RNAi_result (16) | ||||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00000881 | ||||||||
| WBCnstr00000882 | |||||||||
| WBCnstr00010163 | |||||||||
| WBCnstr00015053 | |||||||||
| WBCnstr00036407 | |||||||||
| Construct_product (14) | |||||||||
| Antibody | WBAntibody00001014 | ||||||||
| WBAntibody00001305 | |||||||||
| Microarray_results (32) | |||||||||
| Expression_cluster (205) | |||||||||
| Interaction (158) | |||||||||
| WBProcess | WBbiopr:00000001 | ||||||||
| WBbiopr:00000052 | |||||||||
| WBbiopr:00000096 | |||||||||
| Map_info | Map | IV | Position | 3.25105 | Error | 0.000533 | |||
| Positive | Positive_clone | B0478 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4450 | |||||||
| 4737 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (127) | |||||||||
| Picture | WBPicture0000013081 | ||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
